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Ardea Biosciences Provides Additional Results From a Phase 2b Study of Lesinurad in Combination With Allopurinol at the Annual European Congress of Rheumatology
Date:5/25/2011

ary benefit for gout patients taking this common treatment for hypertension.  Consistent with these preclinical results, a high level of response was observed with lesinurad in the subset of patients receiving thiazide diuretics in study 203.

Results Presented from Phase 1b Study Evaluating the Combination of Lesinurad and Febuxostat

Final results were also presented from a completed Phase 1b study evaluating the combination of lesinurad and febuxostat (Uloric®, Takeda Pharmaceutical Company Limited; Adenuric®, Ipsen and Menarini) in gout patients with sUA of at least 8 mg/dL.

In this Phase 1b clinical study evaluating the use of lesinurad in combination with febuxostat in 21 gout patients, 100 percent of patients receiving the combination achieved sUA levels below 6 mg/dL, compared to 67 percent and 56 percent for patients receiving 40 mg and 80 mg, respectively, of febuxostat alone. With the highest dose of febuxostat combined with either 400 mg or 600 mg lesinurad, 100 percent of patients reached sUA levels below 4 mg/dL.  No patient achieved these reduced sUA levels on this dose of febuxostat alone. The combination of lesinurad and febuxostat was well tolerated with no serious adverse events or discontinuations due to adverse events.

"While the 28-day results from our 203 Study were encouraging, the high rate of sustained uric acid lowering achieved during the extension period, using the lower doses of lesinurad, are even more impressive," said Barry D. Quart, PharmD, President and Chief Executive Officer of Ardea Biosciences. "Continued dosing with 200 mg produced results similar to those seen at 28 days with higher doses, giving us a wide range of doses to consider for the Phase 3 program."

EULAR Posters and Presentations

Ardea's presentation and posters presented at EULAR are available on the Company's website (www.ardeabio.com) un
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SOURCE Ardea Biosciences, Inc.
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