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Ardea Biosciences Presents Preclinical Data on RDEA119 Demonstrating Favorable Anti-Inflammatory Profile for Potential Use in Ulcerative Colitis
Date:5/20/2008

1 study in normal healthy volunteers is ongoing in which the Company is evaluating the pharmacokinetics, safety and tolerability of RDEA119, as well as its ability to inhibit inflammatory cytokines. Preliminary Phase 1 data have demonstrated that RDEA119 has a long half-life and favorable pharmacokinetic properties, allowing for once daily oral dosing. In addition, RDEA119 is currently in a Phase 1 study in advanced cancer patients. The doses being evaluated in the Phase 1 study in advanced cancer patients have achieved systemic exposure consistent with active doses in animal models of human tumors, without drug-related toxicity.

The presentation is available on the Company website (http://www.ardeabio.com/) under the title "RDEA119, a Potent and Highly Selective MEK Inhibitor Ameliorates Murine Colitis."

Corporate Update at Annual Stockholder Meeting

Ardea will provide a corporate update at its Annual Stockholder Meeting. The presentation is scheduled for Thursday, May 22nd, at 9:30 a.m. Pacific Time. To participate by telephone, please dial 877-440-5804 from the U.S. and Canada or +1-719-325-4854 for international callers. In addition, the live conference call is being webcast and can be accessed on the "News & Events" page of the Company's website at http://www.ardeabio.com. A replay will also be available on Ardea's website for 14 days and by telephone through May 31, 2008. For the telephonic replay, please dial 888-203-1112 in the U.S. and Canada or +1-719-457-0820 for international callers, and enter passcode 9342491 when prompted.

About RDEA119

RDEA119, a non-ATP competitive, highly-selective MEK inhibitor for the treatment of inflammatory diseases and cancer, is the Company's lead compound from its MEK inhibitor research and development program. RDEA119 has shown potential as a potent inhibitor of MEK, which is believed
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SOURCE Ardea Biosciences, Inc.
Copyright©2008 PR Newswire.
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