Navigation Links
Ardea Biosciences Presents Preclinical Data on RDEA119 Demonstrating Favorable Anti-Inflammatory Profile for Potential Use in Ulcerative Colitis
Date:5/20/2008

-- Phase 1 RDEA119 data expected in second half of 2008 -- -- Presentation at the Seventh Annual JMP Securities Research Conference on May 21st canceled; webcast of corporate update scheduled during Ardea's

Annual Stockholder Meeting on May 22nd at 9:30 a.m. PT --

SAN DIEGO, May 20 /PRNewswire-FirstCall/ -- Ardea Biosciences, Inc. (Nasdaq: RDEA) today announced that data was presented on the Company's lead mitogen-activated ERK kinase (MEK) inhibitor, RDEA119, demonstrating potent activity in mouse models of colitis. An oral presentation of the data was given at Digestive Disease Week (DDW) 2008 in San Diego, California.

The MEK1/2 pathway is important in cell cycle regulation in inflammatory bowel disease, including ulcerative colitis and Crohn's disease. RDEA119 was shown to reduce damage to colonic tissue in two different mouse models of colitis, murine trinitrobenzene sulfonic acid (TNBS) colitis model and murine dextran sulfate sodium (DSS) colitis model. The beneficial effect observed equaled or exceeded that of sulfasalazine (Azulfidine(R)), a therapy commonly used for acute and maintenance treatment of ulcerative colitis.

"Despite the existing treatments, there are still significant unmet medical needs for inflammatory bowel disease. Blocking the MEK1/2 pathway appears to be a promising strategy in the ongoing search for a new generation of therapies aimed to treat ulcerative colitis and Crohn's disease," said Barry D. Quart, PharmD, Ardea Biosciences' President and CEO. "These data further support the potential use of orally administered MEK inhibitors, such as RDEA119, for the treatment of inflammatory diseases."

To support the development of RDEA119 in inflammatory diseases, a Phase
'/>"/>

SOURCE Ardea Biosciences, Inc.
Copyright©2008 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4

Related medicine technology :

1. Ardea Biosciences Identifies Lead Development Candidate for Gout, RDEA594
2. Ardea Biosciences Appoints John W. Beck Chief Financial Officer, Announces Clinical Development Progress and Reports First Quarter 2008 Financial Results
3. Ardea Biosciences Presents Data Demonstrating Favorable Pharmacokinetics and Efficacy for Mitogen-Activated ERK Kinase (MEK) Inhibitors
4. Ardea Biosciences Reports Positive Phase 2a Results for Lead HIV Candidate, RDEA806, Demonstrating up to 2.0 Log Reduction in Plasma Viral Load
5. Ardea Biosciences Presents Preclinical Data Demonstrating Favorable Resistance Profiles for Non-Nucleoside Reverse Transcriptase Inhibitors for the Treatment of Human Immunodeficiency Virus
6. Ardea Biosciences, Inc. Announces New Clinical Development Program Directed Toward the Treatment of Gout
7. Ardea Biosciences Lead MEK Inhibitor, RDEA119, to Enter Human Clinical Trials in Advanced Cancer Patients
8. Ardea Biosciences, Inc. Presents Results of Phase 1 Studies of RDEA806, a Novel NNRTI for HIV, at 47th ICAAC
9. Ardea Biosciences, Inc. Announces Completion of Phase 1 Clinical Trials of Novel Investigational HIV Drug RDEA806
10. Catalyst Biosciences Selects Drug Development Candidate in Factor VIIa Program for Hemophilia
11. Neurocrine Biosciences Reports First Quarter 2008 Results

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/24/2009)...ONT,Calif.,Nov.24/PRNewswire-FirstCall/--Vermillio...ileditsPlanofReorganizationandDisclosureStatementt...CourtfortheDistrictofDelaware.Ahearingtoconsiderap...forDecember8,2009,withthehearingontheconfirmationo...llsfortheCompanytopayallclaimsinfull.ThePlanisexpe...
(Date:11/24/2009)...MAC,Md.,Nov.24/PRNewswire/--Inadditiontofamily,fri...hiladelphiajurorstoherThanksgivinggratitudelist. ,...hankfultothem,"shesaidofMonday,sverdictstotaling$1..., Wisneskiisamong12,000womennationwidewhohavesued...erapydrugsPremarinandPrempro.Wisneskiandtheothervi...
(Date:11/24/2009)...FORD,Conn.,Nov.24/PRNewswire/--ZargisMedicalCorp.,...fffromSiemensCorporateResearch(NYSE: SI ),todayann...eNovember24,2009episodeofCBS, TheEarlyShow duringa...e magazine,reviewedfivewinningproductsfromthepubli...lyShow isawidely-viewedtelevisionmorningnewstalksh...
Breaking Medicine Technology:Vermillion Files Plan of Reorganization 2Vermillion Files Plan of Reorganization 3Maryland Woman Thankful for Wyeth Verdicts 2Zargis Cardioscan(TM) Featured on The Early Show on CBS 2Zargis Cardioscan(TM) Featured on The Early Show on CBS 3Red Cross Shelters Wildfire Evacuees 55755 1Red Cross Shelters Wildfire Evacuees 55755 2Red Cross Shelters Wildfire Evacuees 55755 3Shrinking Bylot Island glaciers tell story of climate change 9745 1Shrinking Bylot Island glaciers tell story of climate change 9745 2Shrinking Bylot Island glaciers tell story of climate change 9745 3Shrinking Bylot Island glaciers tell story of climate change 9745 4New book on signal transduction 9743 1
(Date:11/26/2009)... No more letters from the North Pole, Textsanta.ne...ges from Santa , North Po...onal efficiencies at the North Pole Santa Claus ha...ll over the globe informed of his Christmas progre...esearch department have identified a large and gro...
(Date:11/26/2009)... Research Triangle Dental (RTDental), a leading de...ay announced the expansion of its services to incl... Doug Macmillan. , Dur...ased to announce that Dr. Doug Macmillan, an exper...additional advanced training seminar. RTDental&rs...
(Date:11/26/2009)... Ennis & Ennis, P.A. is offering free nationwi... Yasmin birth control pills who have suffered a De...ke, Heart Attack or other related cardiac issues o...ll free at 1-800-856-6405 or go to the firm’...t an online case evaluation form. , ...
(Date:11/25/2009)...v.25/PRNewswire/--TheBartleHallConventionCenterwil...nDec.9-10,whenKansasCityhoststhelatestinaseriesofm...eecliniceventhasthepotentialtobethebiggestoneyet,b...heldonweekdaysinsteadofoveraweekend,"SheriWood,exe...esidentoftheNationalAssociationofFreeClinics(NAFC)...
(Date:11/25/2009)...,Nov.25/PRNewswire/-SentinelleMedicalInc.,aleading...dsoftwareandCalgaryScientificInc.,aleadingprovider...ersionofAegis(TM)Breast4DAdvancedVisualizationsoft...zero-footprintWebclientbasedmedicalimagingoffering...allowsforzero-footprintaccess-requiringnosoftwared...
Breaking Medicine News(10 mins):Health News:Text Messages from Santa | Santa goes GREEN by going MOBILE for The March of Dimes 2Health News:Dr. Douglas Macmillan Now Providing LUMINEERS at Research Triangle Dental 2Health News:Ennis & Ennis, P.A. Announces Nationwide Free, Confidential, Consultations For Users Of Yaz And Yasmin Birth Control Pills 2Health News:Ennis & Ennis, P.A. Announces Nationwide Free, Confidential, Consultations For Users Of Yaz And Yasmin Birth Control Pills 3Health News:Kansas City Prepares for Largest Free Health Clinic 2Health News:Sentinelle Medical Inc. Introduces Aegis(TM) Web Powered By Calgary Scientific's PureWeb Technology 2Health News:Sentinelle Medical Inc. Introduces Aegis(TM) Web Powered By Calgary Scientific's PureWeb Technology 3
...irls and 36.3 percent of boys age 12 to 19 in the ...um, placing them at serious risk for osteoporosis ...nt of adult bone mass is established by the end of...h low calcium intake levels during these important...
...g people is leading to an alarming rise in liver c...arply in women after having increased in men for s...nnual report.He adds that females are showing sign...can prevent it from getting worse.Among 35 to 44-y...
...nistrations asked a federal judge to hold the Amer...afety violations in its blood collection program. ...akes much more seriously its role as guardian of t...cree to make substantial improvements in the quali...
...to pump up their physiques should know that many o...up to their label claims. Many people who buy thes...earchers evaluated 12 steroid supplements that the...e product, if stated amounts were found and if the...
...itro fertilisation (IVF) technique intracytoplasmi...babies being born with abnormalities such as ambig...tute in Paris, France, say that men whose infertil... Dr Andre Van Steirteghem of the Free University...
...ld cause a lifelong allergy to a common chemical f...ers warn that the trendy tattoos can lead to month...enna dye itself but the chemical para-phenylene di...di. Dr Bjorn Hausen, of the Dermatological Centre,...
Other Medicine News:
...ional reference laboratory and a worldwide leader ... ARUP offers an extensive test menu of highly comp...mic pathology. Owned by the University of Utah, AR... the nation's university teaching hospitals and ch...
...ional reference laboratory and a worldwide leader ... ARUP offers an extensive test menu of highly comp...mic pathology. Owned by the University of Utah, AR... the nation's university teaching hospitals and ch...
...ional reference laboratory and a worldwide leader ... ARUP offers an extensive test menu of highly comp...mic pathology. Owned by the University of Utah, AR... the nation's university teaching hospitals and ch...
...ional reference laboratory and a worldwide leader ... ARUP offers an extensive test menu of highly comp...mic pathology. Owned by the University of Utah, AR... the nation's university teaching hospitals and ch...
Medicine Products: