Navigation Links
Ardea Biosciences Presents Data Demonstrating Favorable Pharmacokinetics and Efficacy for Mitogen-Activated ERK Kinase (MEK) Inhibitors
Date:4/15/2008

>

"MEK inhibitors may have broad utility in the treatment of human cancers and inflammatory diseases. We are pleased to have two compounds in this class, both with excellent preclinical profiles and promising human pharmacokinetics, moving forward in clinical development," said Barry D. Quart, PharmD, Ardea Biosciences' President and CEO. "We constantly strive to diminish the inherent risk of drug development by having multiple compounds, from structurally different chemical classes, moving through development and we are excited to complete Phase 1 testing of our lead MEK inhibitor, RDEA119, and progress RDEA436 into Phase 1 clinical testing, in the second half of 2008."

The posters are available on the Company website (http://www.ardeabio.com/) under the titles "RDEA119, a Potent and Highly Specific MEK Inhibitor is Efficacious in Mouse Tumor Xenograft Studies" and "RDEA436, a Novel MEK Inhibitor with Favorable Pharmacokinetic Properties."

About RDEA119 and RDEA436

RDEA119 and RDEA436, non-ATP competitive, highly-selective MEK inhibitors for the treatment of cancer and inflammatory diseases, are two of the compounds from Ardea's MEK inhibitor research and development program. RDEA119 has shown potential as a potent and selective inhibitor of MEK, which is believed to play an important role in cancer cell proliferation, apoptosis and metastasis. Preclinical and clinical results suggest that RDEA119 has favorable properties, including oral dosing, excellent selectivity and limited retention in the brain, which, in turn, may result in a reduced risk of central nervous system (CNS) side effects. Preclinical data shows that RDEA436 is a potent in vitro and in vivo inhibitor of MEK, has favorable pharmacokinetic properties with low CNS penetration and a long half-life in a human micro-dose study indicating the potential for once daily dosing in humans.

About Ardea Biosciences

Ardea
'/>"/>

SOURCE Ardea Biosciences, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Ardea Biosciences, Inc. Announces Completion of Phase 1 Clinical Trials of Novel Investigational HIV Drug RDEA806
2. Ardea Biosciences, Inc. Presents Results of Phase 1 Studies of RDEA806, a Novel NNRTI for HIV, at 47th ICAAC
3. Ardea Biosciences Lead MEK Inhibitor, RDEA119, to Enter Human Clinical Trials in Advanced Cancer Patients
4. Ardea Biosciences, Inc. Announces New Clinical Development Program Directed Toward the Treatment of Gout
5. Ardea Biosciences Presents Preclinical Data Demonstrating Favorable Resistance Profiles for Non-Nucleoside Reverse Transcriptase Inhibitors for the Treatment of Human Immunodeficiency Virus
6. Ardea Biosciences Reports Positive Phase 2a Results for Lead HIV Candidate, RDEA806, Demonstrating up to 2.0 Log Reduction in Plasma Viral Load
7. ImmuneRegen BioSciences Reports Material Transfer Agreement with VaxGen, Inc.
8. ImmuneRegen BioSciences, Inc. Demonstrates Radilex(TM) Increases Disease-Fighting White Blood Cells
9. Upstream Biosciences Acquires Innovative Platform Technology and Drug Candidates for Tropical Parasitic Diseases
10. Alacrity Biosciences Announces Positive Results from a Phase 2 Study of Its Dry Eye Treatment ALTY-0501
11. Sangamo BioSciences and Sigma-Aldrich Announce Nature Biotechnology Study Demonstrating Zinc Finger Technology for Modification of Human Stem Cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2015)... SAN FRANCISCO , August 28, 2015 ... is expected to reach USD 49.12 billion by 2020, ... 2020, according to a new report by Grand View ... an estimated CAGR of 49.7% from 2014 to 2020. ... Growing aging population along with rising incidences of ...
(Date:8/27/2015)... 27, 2015 Biosimilars are not generics ... U.S. Food and Drug Administration (FDA) for recognizing ... its draft guidance issued today. The FDA,s draft ... distinguishable names, calling for biological products to bear ... This proposal reflects the agency,s thinking that "there ...
(Date:8/27/2015)... Pa. , Aug. 27, 2015  Now that ... the Da Vinci S™ surgical robot, hospitals with robotic ... plans. They also need to see where they stand ... on the right patients? Have they adopted best practices ... surgery program in the future? ECRI Institute, ...
Breaking Medicine Technology:mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 2mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 3mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 4mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 5Biologics Prescribers Collaborative (BPC) Statement on FDA Draft Guidance entitled "Nonproprietary Naming of Biological Products" 2ECRI Institute's New Robotic Surgery Service Helps Hospitals Brace for Change 2ECRI Institute's New Robotic Surgery Service Helps Hospitals Brace for Change 3
... 2010 CVS Caremark,s (NYSE: ... team was ranked second in the world for ... by Contact Center World at the organization,s Global ...  The awards recognize the best in the contact ...
... CRAIGAVON, Northern Ireland, November 19, 2010 ... ... (typeof(lpUnit)==,undefined,) var lpUnit=,PRN,; --> ... = ,; var first_result; // Results are keyed by longUrl, so we need to grab the first one. for ...
Cached Medicine Technology:CVS Caremark Customer Care Team Awarded Silver Medal for Best Customer Service at Contact Center World's Global Top Ranking Performers Conference 2Almac and the Royal Society of Chemistry Host a Workshop on the use of Analytical Techniques to Control and Monitor Solid Form 2Almac and the Royal Society of Chemistry Host a Workshop on the use of Analytical Techniques to Control and Monitor Solid Form 3Almac and the Royal Society of Chemistry Host a Workshop on the use of Analytical Techniques to Control and Monitor Solid Form 4Almac and the Royal Society of Chemistry Host a Workshop on the use of Analytical Techniques to Control and Monitor Solid Form 5Almac and the Royal Society of Chemistry Host a Workshop on the use of Analytical Techniques to Control and Monitor Solid Form 6Almac and the Royal Society of Chemistry Host a Workshop on the use of Analytical Techniques to Control and Monitor Solid Form 7Almac and the Royal Society of Chemistry Host a Workshop on the use of Analytical Techniques to Control and Monitor Solid Form 8
(Date:8/29/2015)... ... August 29, 2015 , ... ... extend and improve the lives of patients, according to a newly published report. ... to read the full article. , The authors of the new paper ...
(Date:8/29/2015)... ... 2015 , ... ProDrop Particles includes over 40 particle backdrops designed for use ... footage that users can shrink and stretch in the Final Cut Pro X timeline. ... color, brightness, scale, speed, range, and flare attributes with intuitive controls found in the ...
(Date:8/29/2015)... ... August 29, 2015 , ... ... freely market and sell Arterosil and Arterosil HP, and that all claims and ... sued Vascular Health Sciences, LLC (VHS) in the United States District Court for ...
(Date:8/28/2015)... Columbus, Ohio (PRWEB) , ... August 28, 2015 ... ... Saturday’s Imagine No Malaria Day at the Zoo to celebrate children helping children, ... people and their congregations throughout West Ohio have contributed to the United Methodist ...
(Date:8/28/2015)... , ... August 28, 2015 , ... For Dallas, the ... taking part with their subsidiary USPI Tenet Health. , The American Heart Association hosts ... disease and stroke. They believe that together, a difference can be made. Walkers can ...
Breaking Medicine News(10 mins):Health News:Top Mesothelioma Researchers Highlight Targeted Therapies in New Report, According to Surviving Mesothelioma 2Health News:FCPX Effects Developer, Pixel Film Studios, Releases ProDrop Particles. 2Health News:Saturday’s United Methodist Event at Columbus Zoo Celebrates Imagine No Malaria 2Health News:Saturday’s United Methodist Event at Columbus Zoo Celebrates Imagine No Malaria 3Health News:North Central Surgical Center’s Subsidiary Participates in Walk 2
... Commitment to Securing Confidential Customer ... Data for Health Care Technology Leader, BASKING RIDGE, ... Inc., a leader in health care technology solutions,serving nearly half ... 18) that it has maintained the Verizon Business,Security Management Program ...
... With 180 Days ... Exclusivity From Nov. 30, 2011 ... US, GURGAON, Harayana, India and PRINCETON, N.J., June 18 ... an agreement with Pfizer Inc. to settle most of the ...
... eDiets.com,Inc. (Nasdaq: DIET ), leveraging the ... lifestyle solutions to everyone, has appointed Laura,Klein as ... 8 years of senior business experience to eDiets.com ... of IT at Sheridan Healthcare Inc., as well,as ...
... the Sun" volunteers reach new heights in checking for skin,cancer ... ... reporters, HAVRE DE GRACE, Md., June 18 Amidst ... of volunteers,representing the Women,s Dermatologic Society (WDS) broke its national,records ...
... 18 , - The new Lumax ... remote, wireless advanced patient management that,provides daily ... BIOTRONIK GmbH & Co KG, the pioneer ... cardiac devices, announced the launch of the,Lumax ...
... BROOK, Ill. JUNE 18, 2008 According ... preparation with oral sodium phosphate for capsule endoscopy in ... at cleansing the small bowel than the standard method ... procedure. The study appears in the June issue of ...
Cached Medicine News:Health News:TriZetto Maintains Prestigious Verizon Business Security Certification for Sixth Consecutive Year 2Health News:TriZetto Maintains Prestigious Verizon Business Security Certification for Sixth Consecutive Year 3Health News:TriZetto Maintains Prestigious Verizon Business Security Certification for Sixth Consecutive Year 4Health News:Ranbaxy and Pfizer Settle Lipitor Litigation Worldwide 2Health News:Ranbaxy and Pfizer Settle Lipitor Litigation Worldwide 3Health News:eDiets.com(R) Appoints New Chief Information Officer Laura Klein 2Health News:eDiets.com(R) Appoints New Chief Information Officer Laura Klein 3Health News:Maryland Dermatologists Set New Records in Sun Safety Outreach at Popular LPGA Tournament 2Health News:Maryland Dermatologists Set New Records in Sun Safety Outreach at Popular LPGA Tournament 3Health News:Maryland Dermatologists Set New Records in Sun Safety Outreach at Popular LPGA Tournament 4Health News:Tomorrow's care today: Lumax 540 cardiac devices launched at Cardiostim 2Health News:Tomorrow's care today: Lumax 540 cardiac devices launched at Cardiostim 3Health News:Bowel prep oral sodium phosphate equal to fasting before capsule endoscopy for obscure GI bleeding 2Health News:Bowel prep oral sodium phosphate equal to fasting before capsule endoscopy for obscure GI bleeding 3
... new Breast Overlay Apron ... provide extra coverage for ... adjustable velcro flaps allow ... fit, plust added coverage ...
Lap pad used to protect pelvic regions...
... When full protection is necessary, ... Two pieces add to your comfort ... and provide greater flexibility. The vest ... skirt has hanging loops as well ...
Fluoro done? Get rid of your apron quickly and easily without breaking the sterile field. Shoulder pads and hanging straps are standard....
Medicine Products: