Navigation Links
Ardea Biosciences' Lead MEK Inhibitor, RDEA119, to Enter Human Clinical Trials in Advanced Cancer Patients
Date:10/1/2007

- Multi-Center Phase 1 Trial to Commence -

CARLSBAD, Calif., Oct. 1 /PRNewswire-FirstCall/ -- Ardea Biosciences, Inc. (Pink Sheets: ARDC), a company focused on the discovery and development of small-molecule therapeutics for the treatment of viral diseases, cancer and inflammatory diseases, today announced that the U.S. Food and Drug Administration (FDA) granted safe-to-proceed status to the Investigational New Drug (IND) application for RDEA119, enabling initiation of a Phase 1 clinical trial in advanced cancer patients. RDEA119 is a highly potent and selective inhibitor of mitogen-activated ERK kinase (MEK), a key component of the RAS/RAF/MEK/ERK pathway that is commonly defective in human tumors.

Ardea Biosciences plans to conduct the Phase 1 clinical trial at several academic medical centers in the United States. The open-label, dose-escalation trial is designed to evaluate the safety, tolerability and pharmacokinetics of RDEA119 following oral administration in patients with advanced cancer. In addition, the trial is designed to examine biomarkers of therapeutic activity in these patients.

"Cancer is the second most common cause of death in the United States, and, although progress is being made, there is still a significant unmet medical need. The FDA's clearance for us to proceed with our Phase 1 study is a key step forward in the development path for RDEA119, as well as our MEK inhibitor program in general," said Barry Quart, PharmD, President and CEO.

"In clinical trials, MEK inhibitors have been shown to have activity in patients with certain kinds of cancers. With its selectivity, potency and limited penetration into the brain, RDEA119 appears to have a very favorable profile. We are very excited to be selected to participate in the Phase 1 program for this interesting molecule," said Dan Von Hoff, MD, Physician in Chief, Translational Genomics Research Institute and Chief Scientific Officer, Scottsdale Healthc
'/>"/>

SOURCE Ardea Biosciences, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. YM BioSciences Announces Secondary Efficacy and Safety Findings in Randomized Phase IIB Aerolef Trial
2. YM BioSciences Announces Preclinical Data Confirming Nimotuzumab Binds to the EGF Receptor and Potentiates Radiotherapy
3. Sangamo BioSciences Announces Presentation of Phase 1 ZFP Therapeutic Data at American Diabetes Association Meeting
4. Neurocrine Biosciences Announces New Research Studies Presented at APSS Reveal Significant Under-Diagnosis of Insomnia
5. Hana Biosciences Presents Data On Two Programs At the American Society of Clinical Oncology Annual Meeting
6. IR BioSciences Announces Promising Data from Study of Its Compound Homspera
7. Sangamo BioSciences Announces Presentation of ZFP Therapeutic Data From Nerve Regeneration Program at American Society for Neural Therapy and Repair Meeting
8. Lux Biosciences Investigational Therapy for Uveitis, LX211, is Subject of Two Presentations at Key Ophthalmology Meeting, ARVO 2007
9. YM BioSciences Reports AeroLEF Randomized Phase IIb Trial Meets Primary Endpoint in Patients with Post-Surgical Pain
10. Hana Biosciences Announces Data to be Presented On Talvesta (Talotrexin) for Injection at The American Association for Cancer Research Annual Meeting
11. Ace Biosciences, Ace393, the Worlds First Commercial Vaccine for Travellers Diarrhoea Caused by Campylobacter Successfully Completes Phase I Clinical Trials
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... 19, 2014 Five MinuteClinic walk-in medical clinics are opening ... metropolitan area. Three clinics opened in Memphis ... clinic will be added in Springfield on ... is expected to open October 22.  MinuteClinic is the largest ... the United States . The Memphis ...
(Date:9/19/2014)... 19, 2014  Alere Inc. (NYSE: ALR ... following statement today in support of President Barack ... "As the global leader in rapid diagnostics for infectious ... strategy to address the serious threat of antibiotic resistance. ... Administration on initiatives to promote the development of rapid ...
(Date:9/19/2014)... -- BioSpecifics Technologies Corp. (NASDAQ: BSTC ), a biopharmaceutical ... ® in the U.S. and XIAPEX ® in ... , will present a corporate overview at the 21 st ... The presentation will take place on Friday, September ... Hotel in New York, NY . A ...
Breaking Medicine Technology:MinuteClinic Walk-in Medical Clinics Opening in Memphis 2MinuteClinic Walk-in Medical Clinics Opening in Memphis 3Alere Applauds President's Executive Order Combating Antibiotic-Resistant Bacteria 2BioSpecifics Technologies Corp. to Present at the 21st Annual BioCentury NewsMakers in the Biotech Industry Conference 2
... SAN FRANCISCO, Oct. 1 Merriman Curhan Ford Group, ... advisor to TorreyPines Therapeutics, Inc. in the recent merger ... , The combined company is named "Raptor Pharmaceutical Corp." ... NASDAQ Capital Market under the ticker symbol "RPTP." , ...
... PDL BioPharma, Inc. (PDL) (Nasdaq: PDLI ) today announced ... payment of $0.50 per share to all stockholders owning shares ... previously announced, the conversion rate for the Company,s 2.00% Convertible ... shares of common stock per $1,000 principal amount, as a ...
Cached Medicine Technology:Merriman Curhan Ford Acted as Financial Advisor to TorreyPines Therapeutics, Inc. in the Completed Merger With Raptor Pharmaceuticals Corp. 2
(Date:9/20/2014)... (PRWEB) September 20, 2014 Earlier this week, ... customers may have had their credit card information pilfered by ... spawning a slew of headline articles like this one ... the only eye opening numbers. , “Most people tend ... almost like it’s a way to score a game,” says ...
(Date:9/20/2014)... The first federal bellwether trial of a ... week in the U.S. District Court, Northern District of ... that the week opened in the DePuy Pinnacle ... Orthopaedics vice president, who discussed the clinical testing performed ... replacement. According to Reuters, the executive stated that the ...
(Date:9/19/2014)... September 20, 2014 Consistent premium ... for the Vision Insurance industry in recent years; ... detriment of industry margins. From 2009 to 2014, ... operators provide coverage for routine eye exams and ... eyeglasses, contact lens and refractive surgery. According to ...
(Date:9/19/2014)... 19, 2014 (HealthDay News) -- As kids transition from ... of cyberbullies, according to a recent study. ... through 8 found that verbal and physical bullying declines ... bullying intervention and prevention strategies must address all types ... boys and girls, the researchers said. The study was ...
(Date:9/19/2014)... 19, 2014 Visiting Nurse Association (VNA) ... health care, hospice and palliative care and community-based care, ... Opening Bell yesterday at the New York Stock Exchange. ... and social entrepreneur to care for immigrant families suffering ... always worked to meet the urgent healthcare needs of ...
Breaking Medicine News(10 mins):Health News:Don’t Let Data Breach Fatigue Cause Dangerous Cyber Security Complacency 2Health News:Don’t Let Data Breach Fatigue Cause Dangerous Cyber Security Complacency 3Health News:Don’t Let Data Breach Fatigue Cause Dangerous Cyber Security Complacency 4Health News:Don’t Let Data Breach Fatigue Cause Dangerous Cyber Security Complacency 5Health News:Third Week of DePuy Pinnacle Hip Lawsuit Trial Focuses on Clinical Testing of Metal-on-Metal Hip Implant, Wright & Schulte LLC Reports 2Health News:Third Week of DePuy Pinnacle Hip Lawsuit Trial Focuses on Clinical Testing of Metal-on-Metal Hip Implant, Wright & Schulte LLC Reports 3Health News:Third Week of DePuy Pinnacle Hip Lawsuit Trial Focuses on Clinical Testing of Metal-on-Metal Hip Implant, Wright & Schulte LLC Reports 4Health News:Vision Insurance in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Vision Insurance in the US Industry Market Research Report from IBISWorld Has Been Updated 3Health News:Vision Insurance in the US Industry Market Research Report from IBISWorld Has Been Updated 4Health News: Cyberbullying Seems to Ramp Up in Middle School 2Health News:NJ Largest Home Healthcare Not-for-Profit Joins Deutsche Bank to Ring NYSE Opening Bell 2Health News:NJ Largest Home Healthcare Not-for-Profit Joins Deutsche Bank to Ring NYSE Opening Bell 3
... and laboratory rodents seems to throw light on the aspect ... the environment, rather than protecting against it. ... systems of mice and rats which live in laboratories with ... researcher William Parker said, "Laboratory rodents live in a virtually ...
... and Dr. John Read, from the University of Auckland, ... and Madrid about the link between child abuse which ... psychiatric patients and found that they were sexually or ... studies of schizophrenics, they found that the abuse rates ...
... brought into New Zealand by scientists to clarify with the ... laboratory holds the threatening substance for testing it with the ... the Wallaceville manager said it has been imported from Australia ... Well-trained staffs, wearing safe suits are engaged to deal with ...
... system paralysis:,Sir Ian: "There is an urgent timetable, you are right. ... the most challenging in the history of the NHS - because ... our annual report ... and we need to meet the challenge ... is really demanding - and on top of that we need ...
... Health Minister Anbumani Ramadoss Friday warned of "strong action" ... All India Institute of Medical Sciences// (AIIMS), saying a ... hub". ,"Some people have converted the AIIMS into ... them when I return to New Delhi June 19," ...
... new guidelines on obesity finalized to cause harm to ... overweight//. ,Due to financial agreements made between ... an unfit guideline was being made to harm children ... ,The article outlines how an influential expert ...
Cached Medicine News:Health News:NHS acting chief’s intervie 2Health News:New Obesity Guidelines Will Trouble US Children 2
... Universal Torso Shoulder Immobilizer A ... 3/8" foam with contact closure. ... posteriorly. Movable wrist cuff. Plastic ... strap. Shoulder strap may adjust ...
... Brace is designed for the functional management ... separations. Using a pre-inflated aircell, the brace ... joint while supporting the arm and shoulder. ... AC Sport Brace for additional arm support ...
... Humerus Fracture Brace indications: , Nonoperative treatment ... Postoperative treatment of open humeral shaft fractures ... , After removal of internal or external ... Defects resulting from tumor growth , ...
Controls humeral segments through soft tissue compression while allowing for full range of elbow motion...
Medicine Products: