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Ardea Biosciences Identifies Lead Development Candidate for Gout, RDEA594
Date:5/19/2008

with millions of people affected by this debilitating condition," said Barry D. Quart, PharmD, Ardea Biosciences' President and CEO. "With the designation of RDEA594 as our clinical candidate for the treatment of gout, we now expect to have five novel candidates in clinical testing during the second half of 2008, positioning us with the potential to have a broad-based, late-stage pipeline in 2009. This finding also allows us to focus our future development efforts with RDEA806 on the treatment of HIV."

The Company plans to initiate a Phase 1 clinical study of RDEA594 in the second half of this year. As previously announced, the Company also plans to conduct a Phase 2 proof-of-concept clinical study in patients with gout, to confirm RDEA594's activity in the target population using its prodrug, RDEA806. This study is on track to be initiated in the second quarter of this year.

The EULAR presentation details are as follows:

Date/Time: Thursday, June 12, 2008 from 11:45 a.m. - 1:30 p.m. CEST

Title: Safety and Uric Acid Lowering Effect in Humans Following Multiple

Doses of RDEA806, A Novel Prodrug for the Potential Treatment of

Hyperuricemia

Location: Le Palais de Congres de Paris - Level 1 (Abstract # THU0356)

Date/Time: Thursday, June 12, 2008 from 11:45 a.m. - 1:30 p.m. CEST

Title: Mode of Action of RDEA594 as a Uric Acid Lowering Agent in Humans

Following Multiple Doses of its Prodrug, RDEA806

Location: Le Palais de Congres de Paris - Level 1 (Abstract # THU0357)

About Gout

An estimated 3-5 million people in the United States suffer from gout, which is the most common form of inflammatory arthritis in men over 40. Gout, also known as metabolic arthritis, is a painful and debilitating disease caused by abnormally elevated levels of uric acid in the blood stream. These abnormally elevated levels lead to the deposition of uric acid crystals in and around the connecti
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SOURCE Ardea Biosciences, Inc.
Copyright©2008 PR Newswire.
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3. Ardea Biosciences Reports Positive Phase 2a Results for Lead HIV Candidate, RDEA806, Demonstrating up to 2.0 Log Reduction in Plasma Viral Load
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