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Ardea Biosciences Appoints John W. Beck Chief Financial Officer, Announces Clinical Development Progress and Reports First Quarter 2008 Financial Results

nactive status) certified public accountant in the state of California and is a member of the American Institute of Certified Public Accountants and the Association of Bioscience Financial Officers.

Recent Accomplishments

In the first quarter of 2008, we continued to progress our development pipeline in all three therapeutic areas of focus, including:

-- Announced positive preliminary results for RDEA806, our lead non-

nucleoside reverse transcriptase inhibitor (NNRTI), in a Phase 2a

monotherapy study in patients with human-immunodeficiency virus (HIV),

demonstrating an up to 2.0 log placebo-adjusted reduction in plasma

viral load after seven days of treatment;

-- Completed a first-in-human micro-dosing study of our second generation

NNRTI, RDEA427, and selected it as a development candidate;

-- Completed a first-in-human micro-dosing study of our second generation

MEK inhibitor, RDEA436, and selected it as a development candidate;

-- Presented preclinical data demonstrating potent activity and favorable

resistance profiles for our next generation NNRTI family of compounds

against HIV at the 15th Annual Conference on Retroviruses and

Opportunistic Infections (CROI) and the 21st International Conference

on Antiviral Research (ICAR);

-- Presented preclinical data demonstrating the potent activity and

favorable pharmacokinetic profile of our mitogen-activated ERK kinase

(MEK) inhibitor family of compounds in the treatment of cancer,

preliminary Phase 1 data demonstrating the potential for once-daily

oral dosing of RDEA119, our lead MEK inhibitor, and first-in-human

micro-dose data for RDEA436, at the American Association for Cancer

Research (AACR);

-- Established two scientific advisory boards to guide the HIV and

inflammation programs; and

-- Relocated ou

SOURCE Ardea Biosciences, Inc.
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