Navigation Links
Ardea Biosciences, Inc. Presents Results of Phase 1 Studies of RDEA806, a Novel NNRTI for HIV, at 47th ICAAC
Date:9/19/2007

- RDEA806 safe and well tolerated in single-dose and multiple-dose studies

up to 14 days - No evidence of CNS disturbances, rash or elevations in lipids, side

effects observed with other NNRTIs - Pharmacokinetics support further investigation with once- and twice-daily

dosing - Preclinical and Phase 1 clinical data indicate a low propensity for

drug-drug interactions

CHICAGO, Sept. 19 /PRNewswire-FirstCall/ -- Ardea Biosciences, Inc. (Pink Sheets: ARDC) today presented the results of Phase 1 single-ascending-dose, multiple-ascending-dose, food-effect and drug-interaction studies of RDEA806, a novel HIV non-nucleoside reverse transcriptase inhibitor (NNRTI), at the 47th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) [Posters A-1429 and A-1430, Poster Session 160, Antiviral Agents]. To view the posters on-line, go to http://www.ardeabio.com.

Two double-blind, placebo-controlled, Phase 1 studies, conducted in 92 healthy adult male volunteers, of which 78 received RDEA806, demonstrated that RDEA806 was safe and well-tolerated at all doses evaluated with no serious adverse events or clinically significant laboratory or ECG abnormalities. After dosing for up to 14 days at up to 1,000 mg per day, there was no evidence of CNS disturbances or rash, side effects that have been observed with other NNRTIs that are currently marketed or in development. Furthermore, plasma cholesterol and triglyceride levels, which have been shown to increase with many HIV drugs, were stable or decreased during RDEA806 dosing.

The systemic exposure of RDEA806 increased linearly from 50 mg to 600 mg under fasted or fed conditions. The terminal half-life of RDEA806 was up to 11 hours after single doses and up to 13 hours following multiple doses. With doses of 300 mg to 500
'/>"/>

SOURCE Ardea Biosciences, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Ace Biosciences, Ace393, the Worlds First Commercial Vaccine for Travellers Diarrhoea Caused by Campylobacter Successfully Completes Phase I Clinical Trials
2. Inspiration Biopharmaceuticals Presents Data From Hemophilia Program at International Society On Thrombosis and Haemostasis (ISTH) Annual Meeting
3. European Society for Medical Oncology (ESMO) Presents Data from the Clinical Trial of MediGenes Cancer-Killing Virus in Press Conference
4. Cytogen Presents Phase 1 Data Showing Promising Antitumor Activity and Safety Profile of Quadramet at International Myeloma Workshop
5. SemBioSys Presents Positive Insulin Data at the American Diabetes Association Conference
6. Tranzyme Pharma Presents Initial Phase IIa Data for its Novel Ghrelin Agonist, TZP-101, in Patients with Diabetic Gastroparesis
7. Novagali Pharma Presents at AACO the Results of its Pivotal Phase III Clinical Trial of Vekacia in Children Suffering From Vernal Keratoconjunctivitis
8. BioLife Solutions Presents Data on CryoStor at International Society for Cellular Therapy Annual Meeting
9. Genaera Presents Preclinical Data on Trodusquemine (MSI-1436) for the Treatment of Obesity at the American Diabetes Association 67th Scientific Session
10. Elixir Pharmaceuticals Presents Preclinical Data Highlighting Its Ghrelin Antagonist Program at the American Diabetes Associations Annual Meeting
11. DiObex Presents Phase 2a Data of DIO-902 Demonstrating Trends of Improved Glycemic Control and Significant Reductions of LDL-Cholesterol and C-Reactive Protein
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2015)... , March 27, 2015 A new report ... Latin America – Chile , ... are top targets for IVD firms.  The healthcare research ... heavily into IVD strategies for the Latin American continent with ... support globally distributed supply operations. However, the country,s regional economic ...
(Date:3/27/2015)... March 27, 2015 CHINA ... of Senior Care, Rehabilitation Medicine and Healthcare, second to ... industry, will be held at Shanghai New International Expo ... February, 2015,  Implementation Suggestions on Encouraging Private Capital to ... which was jointly issued by the Ministry of Civil Affairs ...
(Date:3/27/2015)... March 27, 2015 As of February, ... incontinence devices for women. "Shipping thousands ... gratifying part is the hundreds of letters, emails ... lives have been positively impacted by our technology," ... InControl recently released Apex, an over-the-counter ...
Breaking Medicine Technology:Kalorama: Beyond Brazil, Latin American IVD Market Grows 2Kalorama: Beyond Brazil, Latin American IVD Market Grows 3Kalorama: Beyond Brazil, Latin American IVD Market Grows 4CHINA AID, the 10th China International Exhibition of Senior Care, Rehabilitation Medicine and Healthcare to be held in April 2CHINA AID, the 10th China International Exhibition of Senior Care, Rehabilitation Medicine and Healthcare to be held in April 3CHINA AID, the 10th China International Exhibition of Senior Care, Rehabilitation Medicine and Healthcare to be held in April 4CHINA AID, the 10th China International Exhibition of Senior Care, Rehabilitation Medicine and Healthcare to be held in April 5CHINA AID, the 10th China International Exhibition of Senior Care, Rehabilitation Medicine and Healthcare to be held in April 6InControl Medical Surpasses 40,000 Shipments Of Incontinence Devices For Women 2
... Roper Industries, Inc. (NYSE: ROP ) ... (CUSIP No. 776696AA4) (the "Notes") will accrue contingent interest for ... at an annual rate of 0.25% of the average market ... January 12, 2011. Contingent cash interest, which the Company has ...
... 18, 2011 Soligenix, Inc. (Soligenix or the ... a late-stage biopharmaceutical company, announced today promising preliminary ... beclomathasone dipropionate or BDP) in a canine gastrointestinal ... that dogs treated with SGX202 demonstrated statistically significant (p=0.04) ...
Cached Medicine Technology:Soligenix Announces Positive Preliminary Results of SGX202 in Radiation Injury 2Soligenix Announces Positive Preliminary Results of SGX202 in Radiation Injury 3Soligenix Announces Positive Preliminary Results of SGX202 in Radiation Injury 4Soligenix Announces Positive Preliminary Results of SGX202 in Radiation Injury 5
(Date:3/30/2015)... NY (PRWEB) March 30, 2015 People from ... scientifically verified benefits of meditation -- yet want a refreshingly ... step-by-step guidance “on-demand” with the new app MindBody Sessions. The ... web at http://www.mindbodysessions.com , or it can be downloaded ... Google Play . , Developed by MindBody Sessions ...
(Date:3/30/2015)... (PRWEB) March 30, 2015 Corra Group is ... accommodate the needs of every industry that requires this form ... compliance mandates or seek new ways to increase productivity and ... drug panels that will help detect substance abuse with a ... mandated drug tests,” said Corra Group Co-Founder, Gordon Basichis. ...
(Date:3/30/2015)... 2015 Considered to be the best ... the global business community, this next generation of the ... by managing big data and frameworks with virtually endless ... powerful analytic and logic features are a technological force ... Lazarus Alliance said “The IT Audit Machine is just ...
(Date:3/30/2015)... March 30, 2015 A new recruitment ... professionals search for their next career move. , Millions ... few years for those with skills in the booming ... http://www.1potato.com , is a jobs aggregator, pulling in opportunities ... and indexing them individually to help candidates find suitable ...
(Date:3/30/2015)... Grove, IL (PRWEB) March 30, 2015 ... online marketing company for mental health professionals, announced ... new relationship allows TherapySites to extend their online ... and promotional offers. , "As we continue to ... therapists to leverage the Internet effectively in order ...
Breaking Medicine News(10 mins):Health News:New Web, iOS and Android App “MindBody Sessions” Makes Mindfulness and Meditation Easy 2Health News:New Web, iOS and Android App “MindBody Sessions” Makes Mindfulness and Meditation Easy 3Health News:Corra Group Adds New Employment Screening Drug Test Solutions for Clients in Every Industry 2Health News:Corra Group Adds New Employment Screening Drug Test Solutions for Clients in Every Industry 3Health News:Building on Success: Next Generation of Cyber Crime Prevention Unveiled! 2Health News:New Global Job Site Launched for Big Data and Analytics Job Seekers 2Health News:TherapySites (Websites for Therapists) Partners with BehaveNet 2
... Health Information Exchange Can Progress in California and ... A statewide system to provide physicians with secure ... to launch in 23 Orange County emergency departments. ... collaboration between the statewide California Regional Health Information ...
... Ariz., Feb. 18 Arizona Technology Enterprises (AzTE), the ... held its first technology forum for investors on Feb. ... with ASU SkySong in Scottsdale, AzTE collaborated with its ... Technology Transfer (CTT). The forum was sponsored and ...
... Broughton Foods of Marietta, OH, is voluntarily recalling the following products:, ... a date of January 14, 2009 or earlier (printed as MM DD YY) and ... Pints of Broughton Citrus Punch with a date of September 17, 2008 ... , Pints of Broughton Fruit Punch with ...
... at the Johns Hopkins Kimmel Cancer Center and Duke University ... IDH2, to nearly three-quarters of several of the most common ... findings: people with certain tumors that carry these genetic alterations ... without them. , Further research on the genes could also ...
... 18 Consumer Watchdog called on the ... make public all communications between top Department ... treatment of autism. Currently, many insurers refuse ... coverage is required by law. Download Consumer ...
... Achieves 20% Sales Growth over Q3 FY 08 and Record Quarterly ... ) today announced results for the quarter ended January 23, 2009. ... of fiscal 2009 compared to the third quarter of fiscal 2008 ... Net sales of $35.3 million, a 20% increase ...
Cached Medicine News:Health News:Statewide Health Information Exchange System to Launch in 23 Orange County Emergency Departments 2Health News:Statewide Health Information Exchange System to Launch in 23 Orange County Emergency Departments 3Health News:Arizona Technology Enterprises (AzTE) Hosts the ASU Tech Forum for the Investment Community 2Health News:Arizona Technology Enterprises (AzTE) Hosts the ASU Tech Forum for the Investment Community 3Health News:Arizona Technology Enterprises (AzTE) Hosts the ASU Tech Forum for the Investment Community 4Health News:Precautionary Allergy Alert on Undeclared Milk Protein in Expired Codes of Broughton Foods' Pints of Orange Juice, Citrus Punch, Fruit Punch and Iced Tea Products 2Health News:2 gene mutations linked to most common brain cancers -- and longer survival 2Health News:Consumer Watchdog Calls on HMO Regulator to Disclose Communications With Insurance Companies Regarding Autism Coverage Denials 2Health News:Cyberonics Continues Strong Sales Growth and Profitability in Fiscal 2009 Third Quarter 2Health News:Cyberonics Continues Strong Sales Growth and Profitability in Fiscal 2009 Third Quarter 3Health News:Cyberonics Continues Strong Sales Growth and Profitability in Fiscal 2009 Third Quarter 4Health News:Cyberonics Continues Strong Sales Growth and Profitability in Fiscal 2009 Third Quarter 5Health News:Cyberonics Continues Strong Sales Growth and Profitability in Fiscal 2009 Third Quarter 6Health News:Cyberonics Continues Strong Sales Growth and Profitability in Fiscal 2009 Third Quarter 7Health News:Cyberonics Continues Strong Sales Growth and Profitability in Fiscal 2009 Third Quarter 8Health News:Cyberonics Continues Strong Sales Growth and Profitability in Fiscal 2009 Third Quarter 9Health News:Cyberonics Continues Strong Sales Growth and Profitability in Fiscal 2009 Third Quarter 10Health News:Cyberonics Continues Strong Sales Growth and Profitability in Fiscal 2009 Third Quarter 11
... the only isosmolar contrast medium (IOCM™) available in ... of blood, VISIPAQUE was designed for patient safety ... medium formulated with sodium and calcium in a ... FDA approval for use in children over one ...
The cordless Simon Dermatome with rechargeable battery is used to harvest split-thickness skin grafts and for debridement....
Hand surgery basic instrument set with round handled instruments...
Dilator...
Medicine Products: