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Ardea Announces Progress with HIV Non-Nucleoside Reverse Transcriptase Inhibitor Program
Date:5/22/2008

Barry D. Quart, PharmD, Ardea Biosciences' President and CEO. "In addition, the excellent preclinical properties of RDEA427 and its long half-life in humans make it the perfect candidate to progress into clinical testing. Developing both RDEA806 and RDEA427 in tandem is consistent with our business strategy of keeping Ardea's pipeline full of novel compounds in areas that are underserved by current treatment options. We are on track to begin a Phase 1 trial with RDEA427 later this year, and expect to initiate a Phase 2b trial with RDEA806 in the third quarter of this year."

About RDEA806 and RDEA427

RDEA806 and RDEA427 are novel, structurally different NNRTIs for the potential treatment of HIV infection. Based on preclinical and clinical studies to-date, Ardea believes that RDEA806 and RDEA427 may have important competitive advantages. These include: the potential for potent antiviral activity against a wide range of HIV viral isolates, including those that are resistant to efavirenz (Sustiva(R), Bristol-Myers Squibb); a high genetic barrier to resistance; the potential to be administered in a patient-friendly, oral dosing regimen; limited pharmacokinetic interactions with other drugs; and the ability to be co-formulated with other HIV antiviral drugs. RDEA806 reproductive toxicity data indicates that future studies, including Ardea's planned Phase 2b trial, would likely include women of child-bearing age in anti-retroviral naive HIV-infected patients.

About Ardea Biosciences

Ardea Biosciences, Inc., of San Diego, California, is a biotechnology company focused on the discovery and development of small-molecule therapeutics for the treatment of HIV, cancer and inflammatory diseases, including gout. We have four drug candidates in clinical trials and others in preclinical development and discovery. Our most advanced development candidate is RDEA806, a non-nucleoside reverse transcriptase inhibitor (NNRTI), which is in a Phase 2a study for
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SOURCE Ardea Biosciences, Inc.
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