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Ardea Announces Data on MEK Inhibitor BAY 86-9766 (RDEA119) to be Presented at EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
Date:11/11/2010

SAN DIEGO, Nov. 11, 2010 /PRNewswire/ -- Ardea Biosciences, Inc. (Nasdaq: RDEA) today announced that data from preclinical and clinical trials of BAY 86-9766 (formerly known as RDEA119) will be presented at the 22nd European Organisation for Research and Treatment of Cancer (EORTC) – National Cancer Institute (NCI) – American Association for Cancer Research (AACR) symposium on "Molecular Targets and Cancer Therapeutics" in Berlin, Germany.  BAY 86-9766 is a mitogen-activated ERK kinase (MEK) inhibitor licensed to and being developed by Bayer HealthCare AG.

The results of a multi-center, Phase 1, monotherapy, dose-escalation study of BAY 86-9766 in advanced cancer patients will be presented by Colin Weekes, MD, PhD, Assistant Professor, Division of Medical Oncology at the University of Colorado School of Medicine. The principal investigators for this study included Dr. Weekes, Daniel D. Von Hoff, MD, Professor of Medicine at the University of Arizona School of Medicine and Executive Vice President of the Translational Genomics Research Institute (TGen), and Alex Adjei, MD, PhD, Professor and Chair, Department of Medicine at the Roswell Park Cancer Institute. In addition, data from preclinical studies of BAY 86-9766, demonstrating its potential for administration in combination with other anti-cancer agents will be presented by Bayer.

"Based on the good tolerability and impressive number of patients who achieved stable disease in this Phase 1 monotherapy trial in refractory patients with advanced solid tumors, we believe BAY 86-9766 has the potential to be a clinically important drug in the treatment of patients across multiple tumor types," said Dr. Adjei. "These monotherapy results support our ongoing Phase 1/2 study of BAY 86-9766 in combination with sorafenib at the maximum tolerated dose defined in this trial and the continued research by Bayer Heal
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