Navigation Links
Arcion Therapeutics' Topical Gel Candidate, ARC-4558, Demonstrates Significant Pain Reduction in Phase 2b Trial for Painful Diabetic Neuropathy (PDN)
Date:7/20/2010

ents in the study applied ARC-4558 0.1% gel or placebo to the affected area three times a day (3.9 mg clonidine per day) for a 12-week treatment period. Patients were able to continue taking a stable dose of their existing pain medications. The primary endpoint of the study related to the change in pain at week 12 compared to baseline measured by the numerical pain rating scale (NPRS).  

About ARC-4558

ARC-4558 is a 0.1% gel formulation of clonidine hydrochloride (HCL) for topical administration to the painful area in order to manage the neuropathic pain associated with painful diabetic neuropathy (PDN).  Topical clonidine, through its agonist effects on alpha2 (a2)-adrenergic receptors, is believed to reduce pain in PDN via local actions on the nociceptors that innervate the affected skin. Based on the results of clinical trials to-date, Arcion believes that ARC-4558 has a level of efficacy comparable to systemic therapies in the target population, but with substantially fewer side effects. The 0.1% gel formulation avoids the treatment area limitations and undesirable aesthetic and skin reaction issues associated with analgesic patches. Furthermore, the ARC-4558 gel has been shown to provide analgesia without numbing or anesthetizing the skin.

About Painful Diabetic Neuropathy (PDN)

Neuropathy is a common complication of diabetes mellitus. According to 2008 estimates by the Centers for Disease Control and Prevention, nearly 18 million people in the United States are diagnosed with diabetes. Given a conservative estimate that 15% of people with diabetes have painful neuropathies, approximately 2.7 million Americans experience PDN. Patients with PDN often experience debilitating pain symptoms that affect day-to-day functioning and quality of life.  How diabetes causes a
'/>"/>

SOURCE Arcion Therapeutics, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Anesiva Announces Merger With Arcion Therapeutics Will Not be Completed
2. Arcion Therapeutics Topical Pain Candidate, ARC-4558, Significantly Reduces Pain Caused by Diabetic Neuropathy
3. Elusys Therapeutics and Lonza Extend Manufacturing Agreement for Anthim, a New Anthrax Treatment in Late-Stage Development
4. Silence Therapeutics and AstraZeneca Extend siRNA Development Collaboration
5. Nile Therapeutics Completes Dosing of Phase II Study
6. Cornerstone Therapeutics Announces Management Change
7. Nonconformity of NOV002 Used in Phase 3 NSCLC Trial Sponsored by Novelos Therapeutics, Inc to NOV002 (Glutoxim(R)), Used in Phase 1/2 NSCLC and all Previous Trials
8. InteKrin Therapeutics Presented Phase 2b Clinical Data at the 2010 American Diabetes Association Annual Meeting, Demonstrating Improved Glycemic Control in Patients with Type 2 Diabetes Without Causing the Edema Seen with Pioglitazone
9. Global Melanoma Therapeutics Industry
10. Tolera Therapeutics Granted Orphan Drug Designation for Treatment of Type 1 diabetes mellitus
11. TransGenRx Protein Therapeutics Technology to Support Research Related to Protein-Based HDL Therapies at Esperion Therapeutics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2015)... 2015  Mallinckrodt plc (NYSE: MNK ) announced ... share repurchase program. The open-ended authorization permits the company ... ordinary shares. "Funding additional initiatives and ... we continue to pursue a range of focused growth ...
(Date:1/23/2015)... BOSTON , January 23, 2015 Heptares ... is delighted to announce that the Malcolm Campbell ... Congreve (Vice President of Chemistry), Fiona Marshall ... (Chief Executive Officer and co-founder) for the seminal contributions to ...
(Date:1/22/2015)... a privately held medical device company, announced today that ... ITOCHU Corporation (Tokyo Stock Exchange TYO: 8001) to sell ... cancer in Japan . ViewRay,s technology, ... only MRI-guided radiation therapy system that images and treats ...
Breaking Medicine Technology:Mallinckrodt plc Announces Share Repurchase Program 2Mallinckrodt plc Announces Share Repurchase Program 3Mallinckrodt plc Announces Share Repurchase Program 4Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 2Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 3Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 4ITOCHU Named the Exclusive Distributor for ViewRay's MRI-Guided Radiation Therapy System in Japan 2
(Date:1/22/2015)... January 23, 2015 AngelWeddingDress, the premier ... 2015 maternity wedding dresses. View website of ... looking for maternity wedding dresses online for a bridal ... with high quality for them. Its maternity wedding dresses ...
(Date:1/22/2015)... Autocarinsurancebest.com has released a new blog post explaining the main ... , Auto insurance quotes help many drivers find the ... to call an agent or visit an agency for price ... website: http://autocarinsurancebest.com/ . , Every business who relies heavily ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Yesterday, ... Bonilla (D-Concord) and Kristin Olsen (R-Modesto) were honored ... leadership in advancing biotechnology, biomedical science, medical device ... Olsen each received the “2014 Life Sciences Champion” ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 EBSCO Information ... (AMA) are expanding their relationship in an effort to further ... the world. While EBSCO has long made AMA journals available ... sales agent for The JAMA Network. , Long ...
(Date:1/22/2015)... 2015 Step into a macabre world ... Museum of Virginia. Wicked Plants, the Museum’s latest featured ... 75 poisonous, carnivorous and diabolical plants inside of a ... uncover the biochemical, physical and neurological processes between botanicals ...
Breaking Medicine News(10 mins):Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2Health News:Commercial Auto Insurance Provides Several Important Features! 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3Health News:EBSCO Expands Partnership with the American Medical Association 2Health News:EBSCO Expands Partnership with the American Medical Association 3Health News:EBSCO Expands Partnership with the American Medical Association 4Health News:Wicked Plants are taking over the Science Museum of Virginia 2
... ... value of Intellimed,s Reporting Tool. , ... Phoenix, Ariz. (PRWEB) March 9, 2010 -- Intellimed International Corporation, a ... medical reporting software system Intellimed Intelligent Client (IM-IC)., , ,Always with an ear to ...
... ... healthcare costs , ... (Vocus) March 9, 2010 -- The Second Annual NACDS RxIMPACT Day on Capitol ... savings and health improvements that result when patients take their medications as prescribed. The ...
... , ... recent interview with NewsWatch TV, Brooklyn Decker, America’s hottest model and covergirl ... and eats healthy on a daily basis. NewsWatch TV is one of America,s ... 700 million viewers through its Video News Release Distribution network. NewsWatch aired ...
... ... ... ... ...
... ... ... ... ...
... ... ... ... ...
Cached Medicine News:Health News:Intellimed's Popular Data Reporting Software IM-IC (Intelligent Client) Receives Latest Update 2Health News:NACDS RxIMPACT "Hill Day" Features More Advocates Increased Focus on Medication Adherence 2Health News:NACDS RxIMPACT "Hill Day" Features More Advocates Increased Focus on Medication Adherence 3Health News:Brooklyn Decker Talks with NewsWatch About Tips on how to stay fit and Healthy 2Health News:Brooklyn Decker Talks with NewsWatch About Tips on how to stay fit and Healthy 3Health News:MedInformatix EPM and EMR Standardizes Care, Raises Efficiency for Affiliates of Non-Profit Physicians Network 2Health News:MedInformatix EPM and EMR Standardizes Care, Raises Efficiency for Affiliates of Non-Profit Physicians Network 3Health News:MedInformatix EPM and EMR Standardizes Care, Raises Efficiency for Affiliates of Non-Profit Physicians Network 4Health News:MedInformatix EPM and EMR Standardizes Care, Raises Efficiency for Affiliates of Non-Profit Physicians Network 5Health News:MedInformatix EPM and EMR Standardizes Care, Raises Efficiency for Affiliates of Non-Profit Physicians Network 6Health News:MedInformatix EPM and EMR Standardizes Care, Raises Efficiency for Affiliates of Non-Profit Physicians Network 7Health News:North American Spine Joins Governor Arnold Schwarzenegger at 2010 ICA Symposium 2Health News:North American Spine Joins Governor Arnold Schwarzenegger at 2010 ICA Symposium 3Health News:North American Spine Joins Governor Arnold Schwarzenegger at 2010 ICA Symposium 4Health News:Aspen Dental Announces Opening of First Practice In Nebraska 2Health News:Aspen Dental Announces Opening of First Practice In Nebraska 3Health News:Aspen Dental Announces Opening of First Practice In Nebraska 4Health News:Aspen Dental Announces Opening of First Practice In Nebraska 5Health News:Aspen Dental Announces Opening of First Practice In Nebraska 6Health News:Aspen Dental Announces Opening of First Practice In Nebraska 7
The latest MAX MARA eyewear collection has evolved into a harmonious balance of tradition and,leading-edge trend, interpreting timeless themes in an absolutely modern way, yet never losing sight,...
Inquire...
Inquire...
... The collection features a range of ... most modern materials and producted to ... collection includes several super lightweight Titanium ... as a whole host of beautifully ...
Medicine Products: