Navigation Links
Arcion Therapeutics' Topical Gel Candidate, ARC-4558, Demonstrates Significant Pain Reduction in Phase 2b Trial for Painful Diabetic Neuropathy (PDN)
Date:7/20/2010

low or undetectable.  No serious or severe adverse events were attributable to ARC-4558 treatment and the topical formulation was well-tolerated at the site of skin application.  

"The top-line data reported today for ARC-4558 provide strong support for Arcion's fundamental approach of applying therapies topically to relieve neuropathic pain by targeting nerve signaling at the level of the skin," said James Campbell, M.D., President and CEO of Arcion. "Through this study, we identified a simple, predictive clinical test to identify non-responders to ARC-4558, which should enable us to optimize subject enrollment in future studies.  Based on our successful End of Phase 2 meeting with the FDA, we believe ARC-4558 will be the first PDN treatment indicated to treat patients who have demonstrable functional nociceptors in the skin.  The full Phase 2b results will be submitted for future peer review and we look forward to advancing the ARC-4558 program in Phase 3 studies."

Michael C. Rowbotham, M.D., Adjunct Professor of Neurology and Anesthesia and Director, UCSF Pain Clinical Research Center, commented, "Painful diabetic neuropathy is frequently a debilitating condition that severely impacts a patient's quality of life and ability to carry out normal day-to-day functions.  There are approved therapies to control the pain, but issues of tolerability and efficacy seriously limit their usefulness.  A novel mechanism-based topical treatment with a low liability of systemic side effects has promise to advance significantly the treatment of this condition and improve the quality of life for a large number of patients."

About the Phase 2b Trial

The Phase 2b study included an adaptive trial design and enrolled a total of 180 adult patients with PDN. Pati
'/>"/>

SOURCE Arcion Therapeutics, Inc.
Copyright©2010 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4

Related medicine technology :

1. Anesiva Announces Merger With Arcion Therapeutics Will Not be Completed
2. Arcion Therapeutics Topical Pain Candidate, ARC-4558, Significantly Reduces Pain Caused by Diabetic Neuropathy
3. Elusys Therapeutics and Lonza Extend Manufacturing Agreement for Anthim, a New Anthrax Treatment in Late-Stage Development
4. Silence Therapeutics and AstraZeneca Extend siRNA Development Collaboration
5. Nile Therapeutics Completes Dosing of Phase II Study
6. Cornerstone Therapeutics Announces Management Change
7. Nonconformity of NOV002 Used in Phase 3 NSCLC Trial Sponsored by Novelos Therapeutics, Inc to NOV002 (Glutoxim(R)), Used in Phase 1/2 NSCLC and all Previous Trials
8. InteKrin Therapeutics Presented Phase 2b Clinical Data at the 2010 American Diabetes Association Annual Meeting, Demonstrating Improved Glycemic Control in Patients with Type 2 Diabetes Without Causing the Edema Seen with Pioglitazone
9. Global Melanoma Therapeutics Industry
10. Tolera Therapeutics Granted Orphan Drug Designation for Treatment of Type 1 diabetes mellitus
11. TransGenRx Protein Therapeutics Technology to Support Research Related to Protein-Based HDL Therapies at Esperion Therapeutics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... 2013  A recently published clinical study conducted at ... , demonstrates that 3D mammography (breast tomosynthesis) significantly ... The study, "Implementation of Breast Tomosynthesis in ... by Stephen L. Rose , MD, ... American Journal of Roentgenology (AJR). The AJR is ...
(Date:5/23/2013)... JERUSALEM , May 23, 2013  Hadasit Bio-Holdings ... portfolio of biotech companies, based on intellectual property ... Israel ,s foremost medical research center, ... Neurosciences Ltd., received significant funding from the Israeli ... Chief Scientist (OCS) to support product development and ...
(Date:5/23/2013)... May 23, 2013  The need to add ... continuum was highlighted prominently at the 108 th ... (AUA), in San Diego.  According to SonaCare Medical, ... ultrasound (HIFU) technology, the need for image-guided technologies ... urologists to consider minimally invasive ablative treatments, was ...
Breaking Medicine Technology:First Large-Scale U.S. Study Validates the Benefits of 3D Mammography (Breast Tomosynthesis) Exams 2First Large-Scale U.S. Study Validates the Benefits of 3D Mammography (Breast Tomosynthesis) Exams 3Hadasit Bio-Holdings Ltd. Portfolio Company - Cell Cure Neurosciences Ltd. Received Additional Government Support 2Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 2Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 3Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 4Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 5Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 6
... -- MUMBAI, India, October 20, 2010 ... ... (typeof(lpUnit)==,undefined,) var lpUnit=,PRN,; --> ... = ,; var first_result; // Results are keyed by longUrl, so we need to grab the first one. for ...
... (Nasdaq: STXS ) announced today that ... and educational video sharing web portal for the ... electrophysiology (EP) and interventional cardiology (IC) procedures from ... Network utilizes Stereotaxis, state-of-the-art Odyssey technology platform to ...
Cached Medicine Technology:Cipla Launches the World's First Generic Pirfenidone in India, Giving Hope to Sufferers of IPF (Idiopathic Pulmonary Fibrosis) 2Cipla Launches the World's First Generic Pirfenidone in India, Giving Hope to Sufferers of IPF (Idiopathic Pulmonary Fibrosis) 3Cipla Launches the World's First Generic Pirfenidone in India, Giving Hope to Sufferers of IPF (Idiopathic Pulmonary Fibrosis) 4Cipla Launches the World's First Generic Pirfenidone in India, Giving Hope to Sufferers of IPF (Idiopathic Pulmonary Fibrosis) 5Cipla Launches the World's First Generic Pirfenidone in India, Giving Hope to Sufferers of IPF (Idiopathic Pulmonary Fibrosis) 6Cipla Launches the World's First Generic Pirfenidone in India, Giving Hope to Sufferers of IPF (Idiopathic Pulmonary Fibrosis) 7Cipla Launches the World's First Generic Pirfenidone in India, Giving Hope to Sufferers of IPF (Idiopathic Pulmonary Fibrosis) 8Stereotaxis Launches the Odyssey Interventional Network for Superior Online Cardiovascular Education and Training 2Stereotaxis Launches the Odyssey Interventional Network for Superior Online Cardiovascular Education and Training 3Stereotaxis Launches the Odyssey Interventional Network for Superior Online Cardiovascular Education and Training 4
(Date:5/24/2013)... mutations central to the development of infantile myofibromatosis (IM)a ... and soft tissuemay provide new therapeutic targets, according to ... Sinai. The findings, published in the American Journal ... options for this debilitating disease, for which the only ... tumors. , IM is an inheritied disorder that develops ...
(Date:5/24/2013)... Mike Stoler believes that there is much to be ... York. That’s why he hosts “Building New York—New ... And that’s why he invited Robert Glazer, Chief Executive ... single specialty practice in the greater New York area, ... and sub-specialists service communities throughout New York and New ...
(Date:5/24/2013)... May 24, 2013 6Webs.com has educated ... out a home security monitoring provider. The ... 6Webs.com the useful resource consumers prefer for unbiased and ... their evaluations of the leading wireless home security system ... are rated on a number of key factors including ...
(Date:5/24/2013)... Bethesda, MD (PRWEB) May 24, 2013 ... to its growing base of clients. As a result ... reports a presence in 20 states around the ... providing medical transcription services to the healthcare industry ... nurses who use their years of clinical work ...
(Date:5/24/2013)... (HealthDay News) -- The number of U.S. patients ... time in an emergency room has increased by ... The study, conducted by researchers at the George ... Services in Washington, D.C., found that patients wait ... before being admitted to the ICU. The researchers ...
Breaking Medicine News(10 mins):Health News:Researchers identify first drug targets in childhood genetic tumor disorder 2Health News:Robert Glazer, Chief Executive Officer of ENT and Allergy Associates, LLP®, Talks About the Business of Succeeding in New York 2Health News:Robert Glazer, Chief Executive Officer of ENT and Allergy Associates, LLP®, Talks About the Business of Succeeding in New York 3Health News:Robert Glazer, Chief Executive Officer of ENT and Allergy Associates, LLP®, Talks About the Business of Succeeding in New York 4Health News:2013 Best Wireless Security System Providers Reported by 6Webs.com 2Health News:The Dictation Source Signs Two National Hospital Chains 2Health News:The Dictation Source Signs Two National Hospital Chains 3Health News:Sharp Rise in ICU Admissions From U.S. Emergency Rooms 2
... Reporter , WEDNESDAY, Oct. 13 (HealthDay News) -- People taking ... or treat osteoporosis may be at risk for a rare ... warned Wednesday. Bisphosphonates work by inhibiting bone loss ... Whether bisphosphonates are the cause of these rare thigh fractures ...
... to give back to the cancer communities in the ... Society for Radiation Oncology (ASTRO) is partnering with Mama,s ... survivorship issues. , Mama,s Kitchen will work with ASTRO ... 52nd Annual Meeting, scheduled for October 31-November 4, 2010, ...
... Gerontological Society of America (GSA) and the National ... PhD, and Tony Noice, PhD, of Elmhurst College as the ... in Creativity and Aging . This award recognizes and ... in the field of creativity and aging shifted the conceptual ...
... By Serena Gordon HealthDay Reporter , TUESDAY, Oct. ... five siblings of children with autism may have subtler problems ... 3,000 children. What isn,t yet clear is if these ... or exactly what type of intervention, if any, might be ...
... Douglas A. Jabs, MD, MBA, Professor and Chair of ... Associates, and Dean for Clinical Affairs at The Mount ... prestigious Jackson Memorial Lecture at the 2010 Annual Meeting ... be published in the November issue of the ...
... systems and symbols on the fronts of food packaging ... four nutrients of greatest concern calories, saturated fat, ... from the Institute of Medicine. These food components ... health problems affecting many Americans, including obesity, heart disease, ...
Cached Medicine News:Health News:Bone Drugs Linked to Rare Fractures, FDA Warns 2Health News:Bone Drugs Linked to Rare Fractures, FDA Warns 3Health News:Noices to receive 2010 Gene D. Cohen Award 2Health News:Siblings of Autistic Children May Also Have Subtle Traits 2Health News:Siblings of Autistic Children May Also Have Subtle Traits 3Health News:Douglas A. Jabs, M.D., honored with Jackson Memorial Lecture by the American Academy of Ophthalmology 2Health News:Douglas A. Jabs, M.D., honored with Jackson Memorial Lecture by the American Academy of Ophthalmology 3Health News:Nutrition rating enhancing front-of-package nutrition rating systems and symbols: Phase 1 2
... Atlas monitor is a low-cost, multi-parameter monitor ... procedures, and surgery. The large display provides ... visible from across the room. The intuitive ... operate the monitor in just minutes., ...
... needed for quality, comprehensive portable and bedside ... allows you to see up to four ... touch screen allows easy navigation through menus ... temperature., ,Standard features include two channels ...
... anesthesia monitor., ,The Cardiocap/5 is ... use in the operating room, ambulatory ... The Cardiocap/5 offers full vital signs ... oxygenation and circulation to advanced airway ...
... for Clinical Professionals and Researchers., ,S/5 Collect ... and efficient way to collect data from Datex-Ohmeda ... days at selectable time intervals. With S/5 Collect ... the monitor via an interface cable or connect ...
Medicine Products: