Navigation Links
Arcion Therapeutics' Topical Gel Candidate, ARC-4558, Demonstrates Significant Pain Reduction in Phase 2b Trial for Painful Diabetic Neuropathy (PDN)
Date:7/20/2010

low or undetectable.  No serious or severe adverse events were attributable to ARC-4558 treatment and the topical formulation was well-tolerated at the site of skin application.  

"The top-line data reported today for ARC-4558 provide strong support for Arcion's fundamental approach of applying therapies topically to relieve neuropathic pain by targeting nerve signaling at the level of the skin," said James Campbell, M.D., President and CEO of Arcion. "Through this study, we identified a simple, predictive clinical test to identify non-responders to ARC-4558, which should enable us to optimize subject enrollment in future studies.  Based on our successful End of Phase 2 meeting with the FDA, we believe ARC-4558 will be the first PDN treatment indicated to treat patients who have demonstrable functional nociceptors in the skin.  The full Phase 2b results will be submitted for future peer review and we look forward to advancing the ARC-4558 program in Phase 3 studies."

Michael C. Rowbotham, M.D., Adjunct Professor of Neurology and Anesthesia and Director, UCSF Pain Clinical Research Center, commented, "Painful diabetic neuropathy is frequently a debilitating condition that severely impacts a patient's quality of life and ability to carry out normal day-to-day functions.  There are approved therapies to control the pain, but issues of tolerability and efficacy seriously limit their usefulness.  A novel mechanism-based topical treatment with a low liability of systemic side effects has promise to advance significantly the treatment of this condition and improve the quality of life for a large number of patients."

About the Phase 2b Trial

The Phase 2b study included an adaptive trial design and enrolled a total of 180 adult patients with PDN. Pati
'/>"/>

SOURCE Arcion Therapeutics, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Anesiva Announces Merger With Arcion Therapeutics Will Not be Completed
2. Arcion Therapeutics Topical Pain Candidate, ARC-4558, Significantly Reduces Pain Caused by Diabetic Neuropathy
3. Elusys Therapeutics and Lonza Extend Manufacturing Agreement for Anthim, a New Anthrax Treatment in Late-Stage Development
4. Silence Therapeutics and AstraZeneca Extend siRNA Development Collaboration
5. Nile Therapeutics Completes Dosing of Phase II Study
6. Cornerstone Therapeutics Announces Management Change
7. Nonconformity of NOV002 Used in Phase 3 NSCLC Trial Sponsored by Novelos Therapeutics, Inc to NOV002 (Glutoxim(R)), Used in Phase 1/2 NSCLC and all Previous Trials
8. InteKrin Therapeutics Presented Phase 2b Clinical Data at the 2010 American Diabetes Association Annual Meeting, Demonstrating Improved Glycemic Control in Patients with Type 2 Diabetes Without Causing the Edema Seen with Pioglitazone
9. Global Melanoma Therapeutics Industry
10. Tolera Therapeutics Granted Orphan Drug Designation for Treatment of Type 1 diabetes mellitus
11. TransGenRx Protein Therapeutics Technology to Support Research Related to Protein-Based HDL Therapies at Esperion Therapeutics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... Ill. , Dec. 19, 2014   Hospira, ... leading provider of injectable drugs and infusion technologies, today ... Morgan 33rd Annual Healthcare Conference on Wednesday, Jan. 14, ... presentation is scheduled to begin at 10:30 a.m. Pacific ... available to all interested parties through a live audiocast ...
(Date:12/19/2014)... SAN DIEGO and CARDIFF-BY-THE-SEA, ... Therapeutics, Inc. (NASDAQ: SRNE ;  Sorrento), ... and associated pain, and Conkwest, Inc., a privately-held ... a Natural Killer (NK) cell-line based therapy, announced ... definitive agreement to jointly develop next generation CAR-TNK™ ...
(Date:12/19/2014)... , Dec. 18, 2014  Sage Analytics ... generation of equipment for the testing of marijuana ... of the new Luminary™ Profiler, the industry,s first ... measurement in a cost-effective, portable unit. ... specific needs of the cannabis industry, the Luminary™ ...
Breaking Medicine Technology:Sorrento and Conkwest Announce Exclusive Global Collaboration 2Sorrento and Conkwest Announce Exclusive Global Collaboration 3Sorrento and Conkwest Announce Exclusive Global Collaboration 4Sorrento and Conkwest Announce Exclusive Global Collaboration 5Sage Analytics Develops Breakthrough System for Potency Testing of Cannabis Products 2
... YORK, July 8, 2011 The U.S. Food and ... Diphtheria Toxoid, and Acellular Pertussis Vaccine, Adsorbed (Tdap)] for ... for active booster immunization against tetanus, diphtheria and pertussis ... vaccine approved for use in this age group.  With ...
... July 8, 2011 /PRNewswire-Asia/ -- Shenzhen Wuzhou Changlian International ... of multifunctional medical and industrial products, is pleased to ... Up to a 35% discount will be offered in ... promotional activity range from infrared thermometers , digital ...
Cached Medicine Technology:GlaxoSmithKline Receives FDA Approval for BOOSTRIX® to Help Prevent Whooping Cough in Adults 65 Years and Older 2GlaxoSmithKline Receives FDA Approval for BOOSTRIX® to Help Prevent Whooping Cough in Adults 65 Years and Older 3GlaxoSmithKline Receives FDA Approval for BOOSTRIX® to Help Prevent Whooping Cough in Adults 65 Years and Older 4Enjoy Only One Thermometer in Various Domains 2
(Date:12/21/2014)... 2014 Khanna Vision Institute is pleased ... the Aspen Helicopters holiday event for underprivileged kids. The ... sleigh, flown by an aspen helicopter pilot. In the ... with sleigh was visible.(please see accompanying video). Helicopter pilots ... has helped many pilots with Pi in eye vision ...
(Date:12/21/2014)... Recently, one of the best prom ... Shop has introduced its new collection of 2015 ... discounts on all its prom dresses & other fashionable ... on providing top quality dress products and great customer ... as one of the best prom dresses online shops ...
(Date:12/21/2014)... 21, 2014 Over the past 39 ... in hundreds of emergency departments across the nation, from ... have been translated into an innovative suite of tools, ... deficiencies and enhance the patient experience. , NES ... staffing and management services for hospitals, announced the development ...
(Date:12/21/2014)... 2014 The Oncology Institute of Hope and ... Ana and Whittier offices. The Hope for the Holidays Toy ... patients and their families during the holiday season. This year, ... 70 children between both offices. This event continues to be ... community service team, store managers and assistant managers came out ...
(Date:12/20/2014)... has recently announced its new collection of sweet 16 ... dresses for the coming new year. , Weddingshe.com ... global women. Now, all the models on its website ... Among the new items, the model of 10986064 (Fresh ... popular. What’s more, Weddingshe.com also provides a fast and ...
Breaking Medicine News(10 mins):Health News:New Prom Dresses From One Of The Best Prom Dresses Online Shops, LunaDress Prom Shop 2Health News:NES Health Launches Stipend Program for Emergency Physicians in Training to Financially Assist Emergency Department Doctors While They Learn 2Health News:Tons of New-in Winter Sweet 16 Dresses from Weddingshe Online Now 2
... , CHICAGO, Sept. 9 Millennium Pharmacy Systems, a leading ... was named to Inc. Magazine,s Inc. 500 list of the ... the third consecutive year. Millennium qualified based on its extraordinary 737.5% ... care pharmacy services provider to make the list. , ...
... , , NEW YORK, ... that it is providing a grant of $200,000 to Abiant, Inc. ... for Alzheimer,s Disease. Abiant, a privately held company, is dedicated ... of neurologic and neuropsychiatric disorders. , , ...
... Rally Against Obamacare , , WASHINGTON, Sept. 9 ... working for a healthcare system that ensures the highest quality and affordable care ... nation for this event and press conference. , , ... When: Thursday, September 10, 2009 , , ...
... , , CINCINNATI, Sept. 9 ... to know that healthful aging depends on our current habits. ... we take precautionary measures to strengthen ourselves," explains the women,s health ... bones are all areas that are often overlooked or taken for ...
... , , NEW YORK, Sept. 9 ... their lifetime. Shape magazine encourages everyone to join the ... Pilates for Pink initiative kicks off! This award-winning fundraiser enables ... , , Shape and The Breast Cancer ...
... HARBIN, China, Sept. 9 /PRNewswire-Asia-FirstCall/ -- China Kangtai ... grower,developer, manufacturer and marketer of a variety of cactus-based ... Annual Global Investment,Conference to be held on September 9-11, ... as part of the Asia Track program on September ...
Cached Medicine News:Health News:Millennium Pharmacy Systems Named to Inc. 500 for Third Consecutive Year 2Health News:Alzheimer's Drug Discovery Foundation Funds Abiant, Inc. to Develop a Positron Emission Tomography (PET) Imaging Diagnostic for Alzheimer's Disease 2Health News:Alzheimer's Drug Discovery Foundation Funds Abiant, Inc. to Develop a Positron Emission Tomography (PET) Imaging Diagnostic for Alzheimer's Disease 3Health News:Leading Women's Health Expert Offers Preventive Tips for Healthful Aging 2Health News:Leading Women's Health Expert Offers Preventive Tips for Healthful Aging 3Health News:Leading Women's Health Expert Offers Preventive Tips for Healthful Aging 4Health News:Get Fit, Give Back 2Health News:Get Fit, Give Back 3Health News:China Kangtai Cactus Biotech to Present at the Rodman & Renshaw Annual Global Investment Conference in New York on September 11, 2009 2Health News:China Kangtai Cactus Biotech to Present at the Rodman & Renshaw Annual Global Investment Conference in New York on September 11, 2009 3
... for the semi-quantitative determination of specific IgA ... results of the anti-Gliadin IgA assay can ... diagnosis of diseases associated with elevated levels ... of these autoantibodies are one indicator in ...
... a high throughput primary or backup ... offers performance and reliability equal to ... instruments. The advanced technology of the ... strips delivers reproducible and accurate results, ...
... was originally developed for the World Health ... function. It has been widely used in ... natural family planning methods. Urine samples are ... measured by EIA (enzyme labelled immunoassay with ...
... 10-8700 ACTIVE® Estrone Enzyme Immunosorbent Assay ... quantitative measurement of Estrone in serum. ... of enzyme immunoassay where there is ... an enzyme-labeled antigen for a fixed ...
Medicine Products: