Archimedes Pharma Announces Successful Proof-of-Concept Results on Two Intranasal Developmen...(cts. Diazepam a long established ...),Health

Diazepam, a long established benzodiazepine, is available in IV and rectal forms for the treatment of epileptic seizures including Acute Repetitive Seizures "ARS" (also described as Bouts of Increased Seizure Activity, 'BISA' or 'breakthrough seizures') in patients with refractory epilepsy. These two routes of administration are associated with significant logistical and compliance issues, especially as treatments are usually administered while a patient is having a seizure. Archimedes IN Diazepam is a simple low-volume solution, which can be delivered in simple, off-the-shelf nasal spray devices offering similar efficacy but potentially greater convenience and acceptability compared to IV and rectal diazepam. IN diazepam has been developed as a ready-to-use disposable nasal spray that can be carried by the patient for immediate use when required.

Archimedes estimates that ARS/BISA affects over 1 million patients in Europe and the US.

About Archimedes Pharma

Archimedes Pharma is a fast-growing specialty pharmaceutical company marketing an expanding portfolio of products to specialist prescribers in Europe whilst building a platform for its future growth through the development of a high-value pipeline from its world-class drug delivery technologies.

Archimedes has an established commercial presence in major European markets and is growing through in-licensing and acquisition of late stage and approved products. It is also building a robust pipeline of in-house products in pain, Parkinson's disease and critical care by applying its drug delivery technologies to proven molecules which have yet to achieve their market potential due to their current mode of delivery. This approach greatly reduces the development risk while promising significant clinical - and thus commercial - benefits. Archimedes' lead product NasalFent(R), uses the Company's PecSys(TM) technology to prod
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