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Approved Biologic Therapies in Rheumatoid Arthritis Show Further Evidence of Efficacy and Reduction in Joint Damage at the 2011 European League Against Rheumatism's Congress
Date:6/8/2011

stracts presented

Life-cycle management trials

Trials including structural outcomes in RA

Trials investigating biomarker/ pharmacogenomic predictors of responseCentocor's golimumab

7

2

3

-Abbott's adalimumab

9

-

2

2BMS's abatacept

10

5

2

3Roche/Biogen/Genentech's rituximab

14

2

2

5Roche's tocilizumab

28

3

2

7Novel therapeutics in RA were also showcased at EULAR. Citeline's Associate Director of Autoimmune/Inflammation, Dr. Laura Runkel, found several presentations from Pfizer to be most notable. Pfizer presented results from its ORAL Sync pivotal trial investigating tofacitinib in combination with traditional DMARDs, as well as data from its ORAL Solo trial, evaluating the oral JAK3 kinase inhibitor as monotherapy.  With the presentation of these results, Pfizer has now shared top-line data for all four of its tofacitinib pivotal trials.

"The company has announced plans to file for FDA and EMEA approval in a wide range of treatment combinations and patient populations by the end of 2011, representing the first filing for a biotechnology-derived, targeted oral treatment for RA," comments Dr. Runkel. "If the filings occur as planned, they will put tofacitinib far ahead of its closest competitor, Rigel/AstraZeneca's fostamatinib, whose syk kinase inhibitor is projected to complete pivotal trials in 2013."

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