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Applying Clinical Findings to the Practice of Medicine
Date:2/25/2009

consisting of polymers, metals, ceramics, drugs and biologics, used in either clinical strategy induced bone regeneration by providing an osteoconductive scaffold and by releasing osteoinductive factors. An osteoconductive scaffold is a material that mimics the normal tissue that the bone cells attach to and make bone, upon which bone can grow and osteoinductive factors are molecules that direct stem cells to become bone cells and make bone.

According to Dr. Yaszemski, "The osteoconductive scaffolds and osteoinductive factors are intended to replace bone graft in these procedures. Usually, the bone graft is harvested from the patient's pelvis, and these new techniques might decrease or eliminate the need for an orthopaedic surgeon to obtain the bone graft from this area of the body."

Dupuytren's Contracture and Frozen Shoulder

Helping patients to regain mobility and pain-free motion was the goal of the 2009 OREF Clinical Research Award recipients Lawrence C. Hurst, MD; Marie A. Badalamente, Ph.D.; and Edward D. Wang, MD. This State University of New York at Stony Brook research team and their paper "Injectable Clostridial Collagenase: Striving Toward Nonoperative Treatment Options for Fibroproliferative Disorders" focused on the use of injectible Clostridial collagenase as an alternative to surgery in treating these conditions.

According to the paper, "Fibroproliferative disorders like Dupuytren's contracture and adhesive capsulitis (frozen shoulder) seriously impact quality of life." Dupuytren's contracture is characterized by a progressive accumulation of collagen in the palm of the hand that causes "Dupuytren's cords to form, leading to a progressive flexion of the fingers...the standard of care is surgery." Dr. Hurst and his team injected Clostridial collagenase to the joint and reduced contractures in metacarpophalangeal and proximal interphalangeal joints within zero degr
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SOURCE American Academy of Orthopaedic Surgeons
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