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Applying Clinical Findings to the Practice of Medicine
Date:2/25/2009

aims to understand how cells at the tendon-to-bone insertion respond to changes in their mechanical environment. "My hope is that this research provides guidance for tissue engineering efforts to improve healing and surgical repair of the tendon-to-bone insertion," stated Dr. Thomopoulos.

Osteoporosis and Osteoarthritis

Hiroshi Kawaguchi, MD, Ph.D. and co-authors at the University of Tokyo won the 2009 Kappa Delta Ann Doner Vaughan Award. Takashi Yamada, MD, Ph.D., Toru Akune, MD, Ph.D., and Naoshi Ogata, MD, Ph.D. worked with Dr. Kawaguchi on "Mouse Genetic Studies on Molecular Mechanisms Underlying Bone and Cartilage Disorders."

This research outlines mouse genetics studies on the molecular backgrounds of representative degenerative skeletal disorders, like debilitating conditions such as osteoporosis and osteoarthritis, which are suffered by millions of people. The molecular mechanisms of both conditions have not been identified, although this promising research attempts to reveal the molecular mechanism. The potential of this research may have the power to stop these bone and cartilage conditions before beginning.

Skeletal Deformity

The third Kappa Delta Award, named in honor of Elizabeth Winston Lanier, went to Michael J. Yaszemski, M.D., Ph.D. and co-author Lichun Lu, Ph.D., of the Mayo Clinic College of Medicine for the paper "Osteoinductive Injectable Degradable Polymeric Scaffolds for Osseous Defect Repair." This research team studied the field of bone tissue engineering and set out to develop orthopaedic biomaterials for treating skeletal disorders. "Bone, after blood, is most commonly transplanted tissue worldwide," the paper stated.

The team used two strategies - one for contained defects, which are holes contained within the bone, and another for segmental defects, which are gaps between bones. The composite biomaterial,
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SOURCE American Academy of Orthopaedic Surgeons
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