Navigation Links
Antigen Discovery, Inc. Awarded Phase II SBIR Grant to Identify Biomarkers Associated with Protection against Malaria
Date:8/13/2012

IRVINE, Calif., Aug. 13, 2012 /PRNewswire/ -- Antigen Discovery, Inc. (ADi) today announced that it has received a Phase II Small Business Innovation and Research (SBIR) award from the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health. The three-year award, totaling approximately $ 2.5 million, is a continuation of a Phase I SBIR grant to scan the Plasmodium falciparum proteome for protective antigens. The funds will support a collaborative research effort between ADi and Sanaria, Inc. to use ADi's proteome microarrays to identify biomarkers associated with responses to the administration of Sanaria's malaria products in human trials, including Sanaria® PfSPZ Vaccine (radiation attenuated sporozoites), Sanaria® PfSPZ Challenge (fully infectious sporozoites), and Sanaria® PfSPZ-CVac (PfSPZ Challenge administered with malaria chemoprophylaxis).  An effective malaria vaccine would greatly benefit the billions at risk throughout the world. "By comparing the serum antibody profiles from vaccinees who are protected with those who are not, we aim to identify surrogate antibody biomarkers associated with sporozoite vaccine mediated protection. Such markers are a critically important component of vaccine development," states Dr. Philip Felgner, Principal Investigator, Founder and Chairman of ADi. According to Dr. Stephen L. Hoffman, Sanaria's Founder and Chief Scientific Officer, "This is an unprecedented opportunity to exploit ADi's unique technology to advance our understanding of protective immunity against malaria, and thereby accelerate development and licensure of a highly effective malaria vaccine."   

Additionally, serum samples will be analyzed from clinical studies conducted at Radboud University Nijmengen Medical Center (RUNMC) in the Netherlands, in which volunteers were completely protected after being immunized by the bite of mosquitoes carrying viable (non-irradiated) PfSPZ while taking chloroquine chemoprophylaxis to prevent blood stage infection. The protection lasted for 2 years.  Dr. Robert Sauerwein, director of the RUNMC studies, stated "This is a very exciting opportunity to gain significant insights into how PfSPZ works to provide robust protection against malaria."  

"We are pleased and privileged to have the opportunity to work with the Sanaria and RUNMC teams on this exciting project and grateful for continued support from the NIAID," said Dr. Xiaowu Liang, President and CEO of ADi.  "We aim to develop a diagnostic test that can predict vaccine mediated protection, and to identify antigens that may be used to produce an effective subunit vaccine."

About Antigen Discovery, Inc.

Antigen Discovery, Inc. is a privately owned biotechnology company located in Irvine, California. ADi has a proprietary high throughput proteomics platform technology for biomarker discovery. The company uses and commercializes its innovative proteome microarrays and testing models to facilitate the development of new diagnostic tests, therapeutics and vaccines for infectious disease, autoimmunity, cancer and more. For more information about ADi see http://www.antigendiscovery.com

Contact:

Angela Yee
ayee@antigendiscovery.com

About Sanaria, Inc.

Sanaria's mission is to develop and commercialize live, whole sporozoite vaccines against malaria. Sanaria's sporozoite based products are being tested in clinical trials in the United States, Africa and Europe. Sanaria also makes available to the research community a range of parasitological and entomological reagents and assay services. For more information, see http://www.sanaria.com.

Contact:

Adam Richman, Ph.D.
arichman@sanaria.com 


'/>"/>
SOURCE Antigen Discovery, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Generex Announces OncUView.tv Interviews Featuring the Antigen Express AE37 Breast Cancer Vaccine at ASCO 2012
2. Generex Augments Antigen Express Scientific Advisory Board
3. Generex Announces New Members of Antigen Express Scientific Advisory Board for the AE37 Breast Cancer Vaccine
4. Generex Announces Presentations of Antigen Express AE37 Breast Cancer Vaccine Data at ASCO 2012
5. Biomedical Advanced Research and Development Authority (BARDA) Exercises Option with Pfenex Inc. To Extend Contract for the Development of a Recombinant Protective Antigen (rPA) Based Anthrax Vaccine
6. Pressure BioSciences, Inc. and Target Discovery, Inc. Expand Strategic License Agreement and Collaboration Supporting TDIs Planned Offering of Personalized Medicine Clinical Diagnostic Services
7. Luminex Corporation Awarded $11 Million Contract by Defense Threat Reduction Agency (DTRA)
8. Biodel Awarded NIH Grant to Develop Concentrated Ultra-Rapid-Acting Insulin Formulations for Use in Artificial Pancreas
9. Frost & Sullivan 2012 New Product Innovation in Bioanalytics Awarded to Protea Biosciences
10. Turner Construction Company Awarded Fort Irwin Replacement Hospital
11. Spot On Sciences Awarded $1 Million DARPA Grant to Develop a Blood Sample Collection Device
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... , June 24, 2016 The Academy of ... recommendations that would allow biopharmaceutical companies to ... entities that make formulary and coverage decisions, a move ... of new medicines. The recommendations address restrictions ... appear on the drug label, a prohibition that hinders ...
(Date:6/24/2016)... PUNE, India , June 24, 2016 ... "Pen Needles Market by Type (Standard Pen Needles, Safety ... 12mm), Therapy (Insulin, GLP-1, Growth Hormone), Mode of Purchase ... published by MarketsandMarkets, This report studies the market for ... is expected to reach USD 2.81 Billion by 2021 ...
(Date:6/23/2016)... -- MedSource announced today that it has selected Datatrial,s ... choice.  This latest decision demonstrates MedSource,s commitment to ... by offering a state-of-the-art electronic data capture (EDC) ... the EDC platform of choice in exchange for ... long been a preferred EDC platform by our ...
Breaking Medicine Technology:
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , the ... Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. , “We ... new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as a method ... —Johnson is one of the first doctors to perform the treatment. Orthobiologics are ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, whether ... latter, setting the bar too high can result in disappointment, perhaps even self-loathing. However, ... their goal. , Research from PsychTests.com reveals that behind the tendency ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic ... many turn to unhealthy avenues, such as drug or alcohol abuse, as a coping ... released tools for healthy coping following a traumatic event. , Trauma sufferers tend to ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Marcy was in a crisis. Her son James, ... out at his family verbally and physically. , “When something upset him, he couldn’t control ... use it. He would throw rocks at my other children and say he was going ...
Breaking Medicine News(10 mins):