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Antigen Discovery, Inc. Awarded Phase II SBIR Grant to Identify Biomarkers Associated with Protection against Malaria
Date:8/13/2012

IRVINE, Calif., Aug. 13, 2012 /PRNewswire/ -- Antigen Discovery, Inc. (ADi) today announced that it has received a Phase II Small Business Innovation and Research (SBIR) award from the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health. The three-year award, totaling approximately $ 2.5 million, is a continuation of a Phase I SBIR grant to scan the Plasmodium falciparum proteome for protective antigens. The funds will support a collaborative research effort between ADi and Sanaria, Inc. to use ADi's proteome microarrays to identify biomarkers associated with responses to the administration of Sanaria's malaria products in human trials, including Sanaria® PfSPZ Vaccine (radiation attenuated sporozoites), Sanaria® PfSPZ Challenge (fully infectious sporozoites), and Sanaria® PfSPZ-CVac (PfSPZ Challenge administered with malaria chemoprophylaxis).  An effective malaria vaccine would greatly benefit the billions at risk throughout the world. "By comparing the serum antibody profiles from vaccinees who are protected with those who are not, we aim to identify surrogate antibody biomarkers associated with sporozoite vaccine mediated protection. Such markers are a critically important component of vaccine development," states Dr. Philip Felgner, Principal Investigator, Founder and Chairman of ADi. According to Dr. Stephen L. Hoffman, Sanaria's Founder and Chief Scientific Officer, "This is an unprecedented opportunity to exploit ADi's unique technology to advance our understanding of protective immunity against malaria, and thereby accelerate development and licensure of a highly effective malaria vaccine."   

Additionally, serum samples will be analyzed from clinical studies conducted at Radboud University Nijmengen Medical Center (RUNMC) in the Netherlands, in which volunteers were completely protected after being immunized by the bite of mosquitoes carrying viable (non-irra
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SOURCE Antigen Discovery, Inc.
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