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Antibiotic Resistance 2013: The Antibiotics Development Pipeline and Strategies to Combat Antibiotic Resistance
Date:4/2/2013

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In the last decade, the capacity to target pathogens has also been undermined by a lack of innovation, which has seen a 60% fall in the numbers of new approvals and few novel molecules. However, as this report has shown, this trend is changing. Today, there are more than 100 candidate antibiotics in development, of which half are in the clinical pipeline. While there are several promising candidates at Phase 3 which offer hope of new approvals in the coming years, Phase 2 developments are now substantial, suggesting the emergence of a new era in the types of antibiotics and the strategies that will be available to target pathogens in the future.

Key Topics Covered:

Executive Summary

Chapter 1 Introduction

1.1 Antibiotic Resistance
1.2 Resistance Mechanisms
1.3 The Resistome
1.4 Pathogenomics
1.5 Strategies and Targets
1.6 The Cost of Antibiotic Resistance
1.7 Global Surveillance
1.8 This Report

Chapter 2 Antibiotic Resistance, Global Trends

2.1 Antibiotic Resistance
2.2 Europe
2.2.1 Carbapenem-resistant Klebsiella pneumoniae and Pseudomonas aeruginosa (2005 to 2010)
2.2.2 Escherichia coli
2.2.3 Streptococcus pneumoniae
2.2.4 Staphylococcus aureus
2.2.5 Enterococcus faecalis
2.2.6 Klebsiella pneumoniae
2.2.7 Pseudomonas aeruginosa
2.3 Other Countries
2.4 China
2.5 USA
2.6 Kuwait
2.7 Discussion

Chapter 3 Marketed Antibiotics

3.1 Marketed Antibiotics
3.2 Mechanisms
3.3 Companies
3.4 Sulphonamides
3.5 Beta Lactams (penicillins, cephalosporins, carbapenems, monobactams)
3.6 Aminoglycosides
3.7 Tetracyclines
3.8 Quinolones/Fluoroquinolones
3.9 Macrolides
3.10 Combinations
3.11 Folate antagonists
3.12 Mycobacter
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SOURCE Research and Markets
Copyright©2012 PR Newswire.
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