Anthera Announces Completion of Enrollment and Dosing in Phase II Trial of A-002 for the Treatment of Cardiovascul...(ing the effectof Once-Daily A-002 on dys...),Health

Date:10/3/2007

ing the effect of Once-Daily A-002 on dyslipidemia (primarily LDL-C) and systemic inflammation in a similar cardiovascular patient population. The trial expects to enroll 120 patients at 15 US sites and patients will be randomized to receive either A-002 (one of two doses) or placebo for eight weeks.

"Preliminary data analysis from our original PLASMA study, which employed twice daily dosing of A-002, suggests that a single daily dose may be sufficient to suppress sPLA2 for up to 24 hours. We look forward to further exploring this opportunity to improve patient convenience," said Jim Pennington, M.D., Chief Medical Officer and Executive Vice President of Anthera Pharmaceuticals. "We are hopeful these studies will provide additional clinical and scientific rationale to further develop A-002 in patients in need of novel therapies to improve their lipid profiles and reduce vascular damage due to inflammation."

Data analysis of the PLASMA Once-Daily Phase II trial is expected to be completed in early 2008. Anthera anticipates the A-002 Phase III program will target patients with coronary heart disease, with associated hyperlipidemia and inflammation who are currently not achieving adequate cholesterol control with diet, exercise, and existing statin therapies such as Lipitor(R). The Phase III program is scheduled to begin during the first half of 2008.

Further information about Anthera's clinical trials and sPLA2 can be found at http://www.PLASMAtrial.com or http://www.anthera.com.

About Anthera Pharmaceuticals

Anthera Pharmaceuticals is a privately-held pharmaceutical development company committed to developing and commercializing clinical products that address unmet medical needs of patients with life-threatening chronic and acute inflammatory diseases. The Company has acquired from Eli Lilly and Company and Shionogi & Co. Ltd. worldw
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SOURCE Anthera Pharmaceuticals, Inc. Copyright©2007 PR Newswire. All rights reserved

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