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Another LNA-based RNA Inhibitor Enters Clinical Trials
Date:3/20/2009

effective Drug Discovery Engine," said Henrik 0rum, CSO at Santaris Pharma. "We are very pleased by the achievement of this milestone and look forward to seeing other new LNA-based compounds advance into clinical trials across a range of therapeutic areas in the near future."

At the Association for Cancer Research (AACR) meeting being held April 18-22, 2009 in Colorado, Enzon Pharmaceuticals will present data on EZN3042 as well as on new LNA targets. Abstracts related to those targets are now available on http://www.aacr.org.

"Novel releasable PEG-nanoparticles enhance delivery of RNA antagonist oligonucleotides in tumor cells and in mice"

"EZN-2208, a novel pegylated SN-38 drug conjugate, markedly inhibits tumor growth and metastatic spreading of human neuroblastoma"

"Androgen receptor (AR) down regulation by locked nucleic acid antisense oligonucleotides specifically inhibits the growth of AR-positive tumor cells"

"The antitumor activity of EZN-4150, a potent LNA-based PIK3CA antagonist"

"EZN-3042, a novel locked nucleic acid oligonucleotide against survivin, inhibits survivin expression and confers taxol sensitivity"

"EZN-3920, an LNA antisense oligonucleotide RNA antagonist, down modulates HER3 expression and PI3K/Akt signaling pathway and enhances antiproliferative effect of Gefitinib in tumor cells"

http://www.santaris.com

About Santaris Pharma

Santaris Pharma is a privately held biopharmaceutical company with exclusive rights to use the LNA Drug Platform to develop new classes of RNA medicines targeting mRNAs and miRNAs associated with disease. The Company's own research and development activities focus on microRNAs, infectious diseases and metabolic disorders. In addition, Santaris Pharma is leveraging it
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SOURCE Santaris Pharma A/S
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