Navigation Links
Another LNA-based RNA Inhibitor Enters Clinical Trials
Date:3/20/2009

COPENHAGEN, March 20 /PRNewswire/ -- Santaris Pharma announced today that the fourth LNA-based drug has been brought into the clinic. In the USA several patients with cancer have now been treated with the Company's Survivin inhibitor, which is jointly developed by Santaris Pharma and Enzon Pharmaceuticals. The U.S. Food and Drug Administration (FDA) recently accepted Enzon Pharma­ceutical's Investigational New Drug (IND) application for the use of the LNA-based Survivin inhibitor.

Survivin is a key protein that controls cancer growth by playing a significant role in cell division, as well as inhibiting the programming that controls cell death. The Survivin inhibitor was developed using the Locked Nucleic Acid technology. In preclinical animal studies, EZN-3042 inhibited Survivin expression and tumor growth. It also potentiated the antitumor activity of taxol, an approved cancer therapeutic.

"Survivin is considered one of the most promising cancer targets and we are pleased that we were able to quickly advance this important compound into patients," said Jeffrey H. Buchalter, chairman and chief executive officer of Enzon Pharmaceuticals.

EZN3042 is one of eight LNA-based RNA inhibitors being developed by Santaris Pharma and Enzon Pharmaceuticals through a comprehensive partnership within the therapeutic area of cancer. Another compound forming part of the collaboration, EZN2968, an LNA-based hif1alfa inhibitor, is currently being investigated in two Phase I/II trials against a variety of cancers. Under the terms of the agreement, Enzon will have exclusive rights to develop and commercialize these compounds in the U.S. and other non-European territories. Santaris Pharma will retain exclusive rights to commercialization in Europe.

"This is the fourth LNA-based drug that has been brought into the clinic in record time either by ourselves or by a partner of ours based on our highly effective Drug Discovery Engine," said Henrik 0rum, CSO at Santaris Pharma. "We are very pleased by the achievement of this milestone and look forward to seeing other new LNA-based compounds advance into clinical trials across a range of therapeutic areas in the near future."

At the Association for Cancer Research (AACR) meeting being held April 18-22, 2009 in Colorado, Enzon Pharmaceuticals will present data on EZN3042 as well as on new LNA targets. Abstracts related to those targets are now available on http://www.aacr.org.

"Novel releasable PEG-nanoparticles enhance delivery of RNA antagonist oligonucleotides in tumor cells and in mice"

"EZN-2208, a novel pegylated SN-38 drug conjugate, markedly inhibits tumor growth and metastatic spreading of human neuroblastoma"

"Androgen receptor (AR) down regulation by locked nucleic acid antisense oligonucleotides specifically inhibits the growth of AR-positive tumor cells"

"The antitumor activity of EZN-4150, a potent LNA-based PIK3CA antagonist"

"EZN-3042, a novel locked nucleic acid oligonucleotide against survivin, inhibits survivin expression and confers taxol sensitivity"

"EZN-3920, an LNA antisense oligonucleotide RNA antagonist, down modulates HER3 expression and PI3K/Akt signaling pathway and enhances antiproliferative effect of Gefitinib in tumor cells"

http://www.santaris.com

About Santaris Pharma

Santaris Pharma is a privately held biopharmaceutical company with exclusive rights to use the LNA Drug Platform to develop new classes of RNA medicines targeting mRNAs and miRNAs associated with disease. The Company's own research and development activities focus on microRNAs, infectious diseases and metabolic disorders. In addition, Santaris Pharma is leveraging its highly effective and efficient drug discovery engine to generate lead LNA drug candidates against a broad array of disease targets selected by strategic partners. Santaris Pharma was founded in 2003 and the Company and its corporate partners currently have four compounds in clinical development and a full pipeline in late preclinical development. Current partners are Enzon Pharmaceuticals, GlaxoSmithKline and Wyeth Pharmaceuticals. Santaris Pharma has since its inception raised nearly $100 million through private financing and up front payments.

About Enzon

Enzon Pharmaceuticals, Inc. is a biopharmaceutical company dedicated to developing, manufacturing and commercializing important medicines for patients with cancer and other life-threatening conditions. The Company has a portfolio of four marketed products, Oncaspar(R), DepoCyt(R), Abelcet(R) and Adagen(R). Enzon's drug development programs utilize several cutting-edge approaches, including its industry-leading PEGylation technology platform and the Locked Nucleic Acid (LNA) technology. Enzon's PEGylation technology was used to develop two of its products, Oncaspar and Adagen, and has created a royalty revenue stream from licensing partner-ships for other products developed using the technology. Enzon also engages in contract manufacturing for several pharmaceutical companies to broaden the Company's revenue base.


'/>"/>
SOURCE Santaris Pharma A/S
Copyright©2009 PR Newswire.
All rights reserved

Related medicine technology :

1. Viatronix V3D-Colon Utilized in Another Landmark Study
2. Semafore Achieves a Preclinical Milestone with SF2626, a PI3K-MEK Dual Pathway Kinase Inhibitor
3. Abbott and Enanta Initiate Phase 1 Clinical Trial on ABT-450 HCV Protease Inhibitor
4. FDA Grants Priority Review of a Supplemental Biologics License Application for Cinryze(TM) C1 Inhibitor (Human) as Treatment for Acute Attacks of Hereditary Angioedema (HAE)
5. Cylene Pharmaceuticals Initiates Phase I Trial With CX-4945 -Breakthrough First-in Class Inhibitor of CK2
6. Video: Femara(R) First Aromatase Inhibitor to Indicate Survival Benefit Versus Tamoxifen When Taken for Five Years After Breast Cancer Surgery
7. SuperGens PIM Kinase Inhibitor, SGI-1776, Effective in Pre-Clinical Models of Acute Lymphoblastic Leukemia
8. New Phase II Data Show Safety of Once-Daily Oral Factor Xa Inhibitor, DU-176b, Comparable to Warfarin in Patients With Non-Valvular Atrial Fibrillation
9. Daiichi Sankyo Initiates Phase III Trial of Its Investigational Factor Xa Inhibitor, DU-176b, in Patients With Atrial Fibrillation
10. TargeGen Affiliates Scheduled for Oral Presentation of Interim Clinical Trial Data at 2008 ASH Meeting in San Francisco for TG101348, a Potent, Selective, Oral JAK2 Inhibitor in Myeloproliferative Disease Patients
11. S*BIO Advances JAK2 Inhibitor SB1518 into Phase 1/2 Clinical Trial in Australia for the Treatment of Chronic Idiopathic Myelofibrosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... WESTPORT, Conn. , Feb. 11, 2016  AfterPill.com ... decision to recommend alcohol abstinence for all women who ... women in the U.S. each year and raises the ... --> --> According to the ... U.S., 70% of women of child-bearing age, who have ...
(Date:2/11/2016)... Wearable posture tracker, ALEX , has taken Kickstarter by storm, crowdfunding over $60,000 – or 120% ... ALEX is said to be delivered to backers starting May of this year. ... ... ... Created by NAMU, a team of biomedical engineers out ...
(Date:2/11/2016)... ANKENY, Iowa , Feb. 11, 2016  Proliant ... New Zealand Bovine Serum Albumin (BSA) manufacturing facility.  The ... New Zealand , in Feilding. ... installation was done to functionally duplicate the systems in ... the same vendors used for U.S. installations.  ...
Breaking Medicine Technology:
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... Dignity Health ... General Hospital Emergency Room –Mesa. The new facility is licensed under Dignity ... , “Dr. Bingham is an excellent leader and will ensure our new freestanding emergency ...
(Date:2/11/2016)... , ... February 11, 2016 , ... “ HEALING MIND ... through a Well Managed Mind” (published by Balboa Press) teaches readers how to become ... being through profound love, author Janice McDermott, M.Ed., LCSW, offers an understanding of how ...
(Date:2/11/2016)... ... February 11, 2016 , ... SPH Analytics ... action analytics leader’s population health solutions, MDinsight® and IndiGO®, for its primary care ... healthcare system. Details of the contract were not disclosed. , As the healthcare ...
(Date:2/11/2016)... ... February 11, 2016 , ... Registered nurses, licensed practical nurses and nursing aides ... Time to Act, Time to Heal” on Thursday, February 25 from 9:00 to 11:00 ... is Vishal Chedda, president of ANSA Consultants, who will discuss clinical best practices throughout ...
(Date:2/11/2016)... ... February 11, 2016 , ... Florida Hospital presents Heart Health ... the St. Louis Blues at the Amalie Arena. The puck drops at 6:00pm, but ... exhibit, the MEGA Heart, prior to the game. The MEGA Heart will be located ...
Breaking Medicine News(10 mins):