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Annual Conference on Vaccine Research to Highlight Not Only Health Benefits But Also Economic Gains
Date:5/5/2008

ults from its Phase IIB trial and plans to start a Phase III trial by the end of 2008.

One Vaccine to Combat Four Bioterrorism Agents

U.S. Army researchers will also report success in mouse experiments with a four-in-one vaccine to protect against anthrax, botulism, plague and staphylococcus -- all of which might be used as bioterrorism agents.

The vaccine, developed by the U.S. Army Research Institute of Infectious Diseases at Fort Detrich, MD along with BD Technologies of Research Triangle Park, NC, provided up to 100 percent protection in vaccinated mice that were challenged with the pathogens.

Researchers, who will present their data, had previously reported success in immunizing mice with separate vaccines for each pathogen. These are the first results to show efficacy with one vaccine against all four pathogens. The vaccine has been constituted as a powder allowing for long shelf life, stability at different temperatures and administration in a variety of ways including subcutaneous injection and as a nasal spray.

A Vaccine to Protect Poultry and People from Deadly Avian Influenza

Researchers from the University of Pittsburgh and the U.S. Centers for Disease Control and Prevention will report progress toward a DNA vaccine against highly contagious and deadly avian influenza (influenza A/H5N1) in poultry.

During an avian influenza outbreak in Southeast Asia in 2003-04, more than 100 million birds either died or had to be killed to stem the disease. In 2007, avian influenza claimed 11 million poultry. The contagion has had devastating consequences for the poultry industry and has raised concerns about transmission to humans. While the virus does not usually infect people and to-date cannot be transmitted easily from person-to-person, more than 200 human cases have been reported, mainly among people who have had close contact with poultry.

Currently, there are two licensed vaccines to combat H5N1 in poultry,
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SOURCE National Foundation for Infectious Diseases
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