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AndroScience Corporation Forms Strategic Alliance With Taiwan Based Orient Europharma to Develop Novel Topical Acne Therapeutic
Date:5/20/2010

tion to improve efficacy.  Upon completion of phase IIb study the ASC-J9® acne program will require ASC partnering with a multinational pharmaceutical company to support future large-scale clinical trials, regulatory approval process, and product launch in the US or EU.  Business development professionals are directed to contact ASC or evaluate the ASC corporate website for additional information on the acne program.

AndroScience Corporation (www.androscience.com)

Founded in 2000, AndroScience Corporation (ASC) is developing two novel small molecule platforms based on the therapeutic targets of the androgen receptor (AR) and select members of the Signal Transducer and Activator of Transcription (STAT) signaling pathway. The first patented family of compounds function through the enhancing degradation of AR protein, a novel mechanism of action described as AR degradation enhancers (ARD enhancers). This pipeline of drug candidates for the androgen-related disorders includes clinical stage dermal programs in acne and alopecia and preclinical programs in prostate cancer, liver cancer and bladder cancer; as well as spinal bulbar muscular atrophy (Kennedy's Disease). The second major drug development program is based on a family of novel small molecules that function as STAT 3 and 5 transcription factors' inhibitor.  Initiated in 2009, preclinical proof of concept data (both in vitro and in vivo) has been obtained and efforts are underway to develop lead drug candidates in the oncology setting for breast cancer, pancreatic cancer, colon cancer, glioblastoma, and other metastatic disease. Additional applications in treating immune mediated disorders are a
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