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AnaptysBio Develops Novel Antibody Scaffold With Extreme Thermostability
Date:12/4/2012

SAN DIEGO, Dec. 4, 2012 /PRNewswire/ -- AnaptysBio, Inc., a privately-held therapeutic antibody company, today announced the publication of a novel full-length antibody scaffold, applicable to the development of highly thermostable antibodies for therapeutic and diagnostic applications, in the journal of Protein Engineering, Design & Selection (PEDS).  

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Entitled "An integrated approach to extreme thermostabilization and affinity maturation of an antibody", Dr. David J. King, chief scientific officer of AnaptysBio, and his team describe a novel IgG scaffold that maintains high binding affinity to its target antigen despite exposure to high temperature conditions for extended periods.   Accelerated stability data indicates that antibodies generated using this technology would remain stable at room temperature for several years.

To date, this novel approach has been successfully utilized by AnaptysBio to generate highly stable antibodies against multiple antigens.  As demonstrated in the aforementioned publication, existing antibodies with poor stability parameters can be effectively transformed by AnaptysBio's SHM-XEL platform to confer high thermal stability, while simultaneously improving binding affinity.   In addition, AnaptysBio has designed diverse library repertoires that permit de novo discovery of high thermostability antibodies in the context of its proprietary SHM-XEL platform. 

"To our knowledge, this publication describes the most stable full-length antibody reported to date," said Hamza Suria, president & chief executive officer of AnaptysBio. "Our ability to generate antibodies with extended room temperature thermostability provides a significant commercial advantage to future antibody-based therapeutic and diagnostic product
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SOURCE AnaptysBio, Inc.
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