Navigation Links
Analysis of Ulcerative Colitis (UC) Time to Symptom Resolution Data from Pivotal Study of LIALDA(TM) (mesalamine) Presented at DDW

eding and stool frequency as a modified UC-DAI sub-score of 0.

Overall, a total of 341 patients with active, mild to moderate UC were analyzed as part of this post hoc analysis of an 8-week study. Patients in the Kamm study received LIALDA 2.4g/day once daily (n=84), 4.8g/day once daily (n=85), Asacol 2.4g/day three times daily (n=86); or placebo (n=86).

The post hoc analysis found that regardless of the definition used for remission, treatment with LIALDA 2.4g/day, or 4.8g/day, or Asacol 2.4g/day resulted in similar median times to symptom resolution that were shorter than placebo. The Kamm study was not designed to compare LIALDA to Asacol. Asacol was included in the study as a reference arm only.

-- Symptom resolution of rectal bleeding at the first day and first of

three days, respectively:

-- LIALDA 2.4g/day: 9 days and 18 days

-- LIALDA 4.8g/day: 9 days and 17 days

-- Placebo: 14 days and 35 days

-- Normalization of stool frequency at the first day and first of three

days, respectively:

-- LIALDA 2.4g/day: 20 days and 33 days

-- LIALDA 4.8g/day: 23 days and 38 days

-- Placebo: 38 days and 53 days

-- Resolution of both rectal bleeding and normalization of stool

frequency at the first day and first of three days, respectively:

-- LIALDA 2.4g/day: 27 days and 37 days

-- LIALDA 4.8g/day: 29 days and 45 days

-- Placebo: 44 days and 56 days

Important Safety Information for LIALDA

LIALDA tablets are indicated for the induction of remission in patients with active, mild to moderate ulcerative colitis. Safety and effectiveness of LIALDA beyond 8 weeks have not been established.

LIALDA is contraindicated in patients with hypersensitivity to salicylates (including mesalamine) or to any of the components of LIALDA. Caution should be exercised

SOURCE Shire plc
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Trubion Announces Preliminary Analysis of Phase IIb Results With TRU-015 in Rheumatoid Arthritis
2. Oncology Drugs Development Update - Worldwide Markets and Forecasts of Approved EGFr/HEr2 Inhibitors, Treatment Costs, Pathway Analysis, Current and Expanded Clinical Indications, and Novel Agents in Development
3. New Data From Large Safety Analysis of MYCAMINE Shows Favorable Clinical Safety Profile
4. Immtech Announces Interim Analysis in Phase III African Sleeping Sickness Trial
5. Analysis Shows Vernakalant Hydrochloride Injection Increases Conversion to Normal Heart Rhythm in Acute Atrial Fibrillation Patients Treated Within 48 Hours of Onset
6. New Analysis of Study Data Shows That Asacol(R) (Mesalamine) Delivers Rapid Symptom Relief for Ulcerative Colitis Patients
7. A Sociolinguistic Analysis of In-Office Dialogue Reveals Psychiatrists and Parents Have Significantly Different Perceptions on ADHD and Psychiatric Comorbidities
8. Favrille Provides Update on Timing of Analysis from Pivotal Phase 3 Clinical Trial; Reports Third Quarter 2007 Financial Results
9. Results Of VYVANSE(TM) (lisdexamfetamine dimesylate) Effect Size Analysis Presented at Major Scientific Meeting
10. Progen Presents Additional Analysis of Data from PI-88 Phase 2 Liver Cancer Study at American Association for the Study of Liver Diseases
11. Retrospective Analysis Finds That Initiation of Insulin Glargine in Patients With Type 2 Diabetes was Associated With a Lower Incidence Rate of Myocardial Infarction as Compared With NPH Insulin
Post Your Comments:
(Date:8/22/2014)...  - MediaLINC unlocks ... Lincor announced general availability of MediaLINC - ... range of education, entertainment and clinical content direct to ... , " Lincor has already ... engagement to bedside smart devices, " comments Dan ...
(Date:8/21/2014)... Aug. 21, 2014  Aptuit LLC announces that ... Indiana , has enhanced its capabilities in ... small and large molecules, including biologic drugs, metabolites, ... maXisPlus Q-TOF mass spectrometer. In making ... Aptuit, said, "The expanded large molecule capability enhances ...
(Date:8/21/2014)... , Aug. 21, 2014 The spinal column is ... human body. Signals carried to and from the brain through ... and nervous system. Injury or ailment here can be life ... a loss of control over their body. Though back injury ... person,s life, there are more options available to make things ...
Breaking Medicine Technology:Lincor Unveils Next Generation TV-based Patient Engagement Solution 2Aptuit SSCI Adds Ultra High Resolution Q-TOF Mass Spectrometer for Large & Small Molecule Analyses 2Don't Live in Pain: Four Life Improving Benefits of Back Surgery 2
... Demonstrates Commitment to Patient Safety; Approved Sites Eligible to Advertise through ... , , ... July 28 The National Association of Boards of Pharmacy ... Kerr Drug as the first online pharmacy services to be approved ...
... , BOCA RATON, Fla. , July 28 ... with Tris Pharma, the company will market Methylphenidate Solution, ... Inc., under an Abbreviated New Drug Application (ANDA).  Under ... manufactured by Tris Pharma, and marketed and distributed by ...
Cached Medicine Technology:NABP Grants First 'Approved e-Advertiser' Status to, QC Supply, and Kerr Drug 2NABP Grants First 'Approved e-Advertiser' Status to, QC Supply, and Kerr Drug 3Breckenridge Pharmaceutical to Market Methylphenidate Oral Solution Through Agreement With Tris Pharma (Monmouth Junction, NJ) 2
(Date:8/22/2014)... (PRWEB) August 23, 2014 Recently,, ... its new collection of discounted wedding gowns . ... announced that all these new products are provided with ... are very happy to unveil the new wedding gowns. ... special occasion gowns for ladies to choose from. What’s ...
(Date:8/22/2014)... The LSU Health New Orleans School of ... Traineeship grant to increase access to advanced nursing ... under-represented groups, as well as veterans. The Health ... of Health and Human Services awarded the two-year ... the grant,s project director., The Advanced Education Nursing ...
(Date:8/22/2014)... Natural Clear Vision , a how-to guide ... vision from legally blind to perfect 20/20 vision has caught ... , “There is a huge portion of the population today ... most people just think that’s the way it will always ... be pretty risky at times,” reports Michaels. “This program is ...
(Date:8/22/2014)... somatic mutation at amino acid 918 in the RET ... cell lung cancer (SCLC) tumors and enforced expression of ... signaling and cell growth. , SCLC is a highly ... lung cancers and is strongly associated with tobacco smoking. ... examined for genomic alterations and targeted therapies are approved ...
(Date:8/22/2014)... (PRWEB) August 22, 2014 Restore ... Sen and Dr. Samantha Pearson to help people discover ... avoid corrective vision surgery by instead improving their eyesight ... an investigative review. , “There’s a reason why ... in revenue each year—it’s because people just assume that ...
Breaking Medicine News(10 mins):Health News:Discounted Wedding Gowns For Sale At Leading Online Shop 2Health News:Natural Clear Vision: Review Exposes Kevin Richardson’s Program for Restoring Vision Naturally 2Health News:Novel oncogenic RET mutation found in small cell lung cancer 2Health News:Restore My Vision Today: Review Exposes Natural Eye Restoration Guide by Dr. Sen and Dr. Samantha Pearson 2
... Delhi went on mass casual leave Monday, joining ... the sufferings of patients. ,The majority of ... University College of Medical Sciences (UCMS) and Safdarjung ... resentment against the government decision to implement 27 ...
... zero alcohol quotient is highly conducive for the cognitive ... research has suggested//. Infact, even moderated alcohol intake during ... unborn child. ,The study conducted by the University ... Washington, has shown that those children, whose mothers had ...
... over 3500 and an incalculable number of people injured after ... cope with the injured and the dead. ,The quake ... city of Yogyakarta which is near the southern coast of ... left the city in shambles, cutting off communications and road ...
... American study conducted by Arthur Krigsman, of New York ... links to autism//. MMR inoculation is given to young ... But recently there have been claims that the vaccine ... fall in the MMR vaccine uptake rate which has ...
... the world and it has drastically affected the sales of chicken ... for chicken// and the sales are slowly picking up in the ... stage. ,Mohamed Al Shafei, director of the General Union ... great deal in the past with a large number of chickens ...
... very similar to the technology in the United States, and ... for filling up nursing vacancies. With India also being rated ... are realizing their dream of seeking greener pastures. , ... from India who will be joining the hospital during this ...
Cached Medicine News:Health News:Mass Leave By Doctors Leaves Patients Helpless 2Health News:Indonesian Earthquake – Story of Destruction, Death and Disease 2
... replace the carpal scaphoid bone. The implant has ... under a shelf formed in the carpal trapezium ... the proximal hole for suture fixation. These temporarily ... period until a firm capsuloligamentous system has formed ...
... has the same anatomical configuration as the ... to provide for stability. The implant has ... use in suture fixation through the scaphoid ... while a capsuloligamentous system forms around the ...
... for four corner fusion of the capitate, ... hand. The plate is intended for use ... of function due to SLAC and SNAC ... rheumatoid arthritis. When combined with the specially ...
The 3.0 mm Cannulated Screw can be used with or without threaded washer. Uses 1.1 mm threaded or non-threaded guide wire. , ,The Threaded Washer provides a recessed internal buttress which allows the...
Medicine Products: