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Analysis of Caliper's Phase I EPA ToxCast™ Data Published in Leading Scientific Journal
Date:2/24/2011

EPA's National Center for Computational Toxicology, as well as Arthur Weissman, Ph.D., who serves as Caliper's Principal Investigator under its contract with the EPA for the ToxCast program.                

"We are pleased with the confirmation of the high quality of our ToxCast data reported in this article, as well as the finding that both previously known and novel targets of signaling pathways potentially involved in toxicity mechanisms were identified. Caliper's LabChip® platform in particular was instrumental in demonstrating some types of both kinase inhibition and kinase activation as possible novel toxicity mechanisms," said David Manyak, Ph.D., Executive Vice President of Caliper. "The new funding commitments from EPA will allow us to generate dose response information for the Phase II screening of 700 additional chemicals now underway, as well support an additional round of compound screening to create more detailed models around specific potential toxicity targets."  

"These results underscore Caliper's strategy to become a leader in personalized medicine tools and CRO services," commented Kevin Hrusovsky, President and Chief Executive Officer.  "As we evolve into companion diagnostics and patient stratification CRO services, we believe our unique ToxCast capability will help identify toxicity biomarkers that have the ability to rescue drugs that had failed due to toxicity but have the ability to be efficacious and safe for a patient population subset.  These data will help us to garner additional interest from pharmaceutical and biotechnology companies as we build these enabling CRO services."

Caliper will be hosting a webinar at 1:00 pm EST today (Thursday, February 24), at which Dr. Weissman will present an overview of predictive toxicology and safety pharmacology research programs and offerings of Caliper's Discovery Alliances and Services (CDAS) business unit. Please re
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SOURCE Caliper Life Sciences, Inc.
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