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Analysis of Caliper's Phase I EPA ToxCast™ Data Published in Leading Scientific Journal
Date:2/24/2011

HOPKINTON, Mass., Feb. 24, 2011 /PRNewswire/ -- Caliper Life Sciences, Inc. (Nasdaq: CALP), today announced that the results of its initial screening efforts under the U.S. Environmental Protection Agency's (EPA) ToxCast program have been published in the scientific journal Toxicology. Key findings reported include (1) a high level of quality and reproducibility in the dataset allowing for robust statistical analyses, and (2) the role that specific targets in biological pathways could play in toxicity events. These findings underscore the success of the Phase I ToxCast effort and support continued expansion of the program to build predictive models for identifying chemicals with high risk for human toxicity or environmental hazard.  Caliper has recently been awarded three new task orders with an aggregate value of $3.1 million to fund additional activities under the EPA ToxCast program.  

The initial goal of the ToxCast program is to create a database of in vitro (laboratory) assay data on a broad set of compounds for which in vivo (animal) safety data already exists. The Toxicology article covers the first phase of ToxCast data produced by Caliper, which involved more than 93,000 chemical-assay pairs. Caliper has contributed 292 assays, more than half of all of the assays, to the EPA ToxCast program. The long term goal of this program is to identify in vitro assays that can predict toxicity in humans and animals and then employ those predictive tests to supplement or replace existing animal-based tests, thus reducing the cost and improving the speed of regulatory approval of new environmental chemicals.    

The article published in Toxicology (Volume 282, Nos. 1-2, pp. 1-15) is entitled "Activity profiles of 309 ToxCast chemicals evaluated across 292 biochemical targets".  The authors include senior scientific staff from
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SOURCE Caliper Life Sciences, Inc.
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