Navigation Links
Analysis Shows BYDUREON™ Was Not Associated with Clinically Relevant QT Prolongation in Patients with Type 2 Diabetes: Results Presented at ADA 2011
Date:6/24/2011

SAN DIEGO, June 24, 2011 /PRNewswire/ -- Amylin Pharmaceuticals, Inc. (Nasdaq: AMLN), Eli Lilly and Company (NYSE: LLY) and Alkermes, Inc. (Nasdaq: ALKS) today announced results from an analysis of the DURATION-1 study that showed the investigational type 2 diabetes medication BYDUREON™ (exenatide extended-release for injectable suspension) was not associated with clinically relevant QT prolongation in patients with type 2 diabetes. These findings will be presented in a poster session at the 71st Scientific Sessions of the American Diabetes Association in San Diego on Saturday, June 25 from 11:30 a.m. to 1:30 p.m. PDT.

The QT interval represents the amount of time the heart's electrical system takes to repolarize, or recharge, after each beat.(i) Drugs that substantially prolong the QT interval have been associated with cardiac arrhythmias.

This analysis used data from the DURATION-1 study to evaluate changes in the QT interval associated with BYDUREON, correcting for heart rate with Fridericia's formula (QTcF). The change in QTcF from baseline was small and clinically insignificant at 14 weeks (1.7 milliseconds) and 30 weeks (3.0 milliseconds). There was no correlation between change in QTcF and exenatide blood plasma concentrations or renal status.

"These results suggest BYDUREON does not produce clinically relevant QT prolongation," said Christian Weyer, M.D., senior vice president, research and development, Amylin Pharmaceuticals. "To further characterize the QT-related safety of BYDUREON, we are currently conducting a thorough QT study according to guidelines set by the FDA. We believe that BYDUREON could be an important treatment option for patients with type 2 diabetes, and we continue to
'/>"/>

SOURCE Amylin Pharmaceuticals, Inc.; Eli Lilly and Company; Alkermes, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8

Related medicine technology :

1. Analysis Compares Cost-Effectiveness of Premixed Insulin Analogs to Long-Acting Insulin Analogs in the Long-Term Treatment of Type 2 Diabetes in the U.S.
2. Analysis Finds BYETTA® Associated with Lower Likelihood of Heart Failure Compared with Other Diabetes Therapies: Results Presented at ADA 2011
3. PRA Early Phase Leaders to Speak at Bioanalysis Forum
4. Dr. Assad Al-Ammar Joins Irvine Pharmaceutical Services as the New Minerals Analysis Manager in Response to the Growing Needs for USP Elemental Impurities Testing
5. Reportlinker Adds Distributor Analysis of the Pharmaceutical Industry in Key SADC Countries
6. Post Hoc Analysis from RECOVER Study Examined Effects of Neupro® (Rotigotine Transdermal System) on Surrogate Markers of Mood and Anhedonia in Parkinsons Disease
7. ForteBio Introduces New Biosensor for Kinetic Analysis and Screening of Mouse IgG Antibodies
8. Hip Resurfacing Implants - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017
9. Reportlinker Adds Hip Replacement Implants - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017
10. Reportlinker Adds Neurostimulation Devices - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017
11. Reportlinker Adds Hearing Aid Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2017
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... , May 22, 2015 /CNW/ - More than fifty years ... treat morning sickness in expectant mothers. Tragically, Thalidomide caused serious ... families. Support has been provided to survivors ... of Canada in 1991 and settlements ... of a legal obligation to provide support, we have a ...
(Date:5/22/2015)... Solutions, Inc. (NASDAQ: BLFS ), a leading developer, manufacturer ... and cryopreservation freeze media and precision thermal ... "Company"), announced that the Company is scheduled to present at ... is scheduled to present at the Conference at 1:30 p.m. ... Hotel in New York City and ...
(Date:5/22/2015)... 22, 2015 Electrophysiologist Kevin Makati, M.D. ... to Boston, MA to ... Heart Rhythm Society conference. These scientific sessions drew ... the ideas, people and technology that propel their ... hybrid, minimally invasive cardiac operation that combines the ...
Breaking Medicine Technology:Statement from Minister Ambrose on Thalidomide 2Statement from Minister Ambrose on Thalidomide 3BioLife Solutions To Present At The 2015 Marcum MicroCap Conference In New York City 2St. Joseph's Hospital Heart Institute Physician Presents at Heart Rhythm Society 2St. Joseph's Hospital Heart Institute Physician Presents at Heart Rhythm Society 3
(Date:5/23/2015)... On May 16, the team at Farrell’s ... 5k mud obstacle run that raised funds for multiple sclerosis. ... and the reason we participated was to support people living ... Farrell’s eXtreme Bodyshaping. “One-hundred percent of the funds raised go ... was not only attended by eXtreme Bodyshaping staff, but members ...
(Date:5/23/2015)... Javon Bea Mercy Health System CEO ... Rehabilitation Center, 557 N. Washington St., Janesville, will host ... 5:30-6:30 pm. , The 8-week clinic is lead by ... BSN, who will offer training that encompasses a warm-up, ... and show selection and weekly training plans. , The ...
(Date:5/22/2015)... The world is at a "hinge ... to create new opportunities for leadership in health ... WesternU's 34th annual Commencement Exercises said Wednesday, May ... former San Francisco mayor and likely 2018 gubernatorial ... ceremony for WesternU's colleges of Allied Health Professions ...
(Date:5/22/2015)... Utah (PRWEB) May 22, 2015 Mountain Point ... host a ribbon cutting ceremony on Friday, May 29, 2015 ... p.m. to 6 p.m. The new medical center, set to ... North Triumph Boulevard, Lehi, UT 84043. , “The opening ... our team and the Utah County community,” said Kent Loosle, ...
(Date:5/22/2015)... (PRWEB) May 22, 2015 Following yesterday’s ... sale agreement with US-based health brand Nature’s Way, Marc ... brand. Retention of Ascenta Skin is an integral part ... excited about this opportunity to further develop Ascenta Skin ... , Ascenta Skin is a breakthrough, anti-aging skincare supplement ...
Breaking Medicine News(10 mins):Health News:Farrell’s eXtreme Bodyshaping Team Runs through the Muck for MS 2Health News:Newsom to WesternU Grads: The Future is Inside You 2Health News:Newsom to WesternU Grads: The Future is Inside You 3Health News:Mountain Point Medical Center, a Campus of Jordan Valley Medical Center, Hosts Ribbon Cutting Ceremony and Community Celebration on Friday, May 29, 2015 2Health News:Ascenta Skin President Announces Plans to Grow Brand 2
... Cheung, M.D., a pediatric neurologist at The Childrens ... School of Medicine, has been named a Howard ... competition in 2007, Cheung was one of 15 ... , Like all those chosen, Dr. Cheung ...
... (31 January 2008)Twenty-one boxes filled with 7,000 unique seed ... to the Svalbard Global Seed Vault, a facility being ... as a repository of last resort for humanitys agricultural ... Norwegian government as a service to the global community, ...
... put together a report, the Mental Health Advisory Team IV, that studied soldier ... a sobering look at that study, exploring the three most critical elements of ... The intensity of combat and other stressors of those serving ... Battlefield ethics , ...
... Jan. 30 Prime Therapeutics (Prime) has,joined the ... participant from,the pharmacy benefit manager (PBM) industry. The ... that collaborates with leading,organizations to develop and promote ... improving the health of employees. Members,of the Center ...
... Jan. 30 Orbel,s recent facility expansion,in ... for,electroplating metal foils. Motivated by current exchange ... looking toward US suppliers for,cost-effective solutions to ... and increased capacity, Orbel is well-positioned to ...
... Mass.More than 13 million Americans have survived a heart ... (CHD), the number one cause of death in the ... as a healthy diet and exercise, are known to ... evidence, a high proportion of heart attack survivors do ...
Cached Medicine News:Health News:Genetics researcher at Children's Hospital selected as Howard Hughes Medical Institute Investigator 2Health News:African seed collection first to arrive in Norway on route to Arctic seed vault 2Health News:African seed collection first to arrive in Norway on route to Arctic seed vault 3Health News:Prime Therapeutics Becomes First PBM to Join the Center for Health Value Innovation 2Health News:UMass Medical School study finds patients diagnosed with coronary heart disease continue poor diets 2Health News:UMass Medical School study finds patients diagnosed with coronary heart disease continue poor diets 3
... The Featured Products ... at Mediflex and are ... modular in regular or ... come equipped with insulation, ...
Operate with confidence. Autosuture is advancing the sate of both open and minimally invasive surgery by providing surgical tools that feel right, function right, and facilitate the right outcome eve...
Operate with confidence. Autosuture is advancing the sate of both open and minimally invasive surgery by providing surgical tools that feel right, function right, and facilitate the right outcome eve...
... are offered as 1-piece or modular, in ... instruments may be customized with handles of ... insulation and flush ports. Many standard patterns ... may affect delivery times. , Please ...
Medicine Products: