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Analysis Finds Improvements in Health-Related Quality of Life for Hereditary Angioedema Patients Treated with C1-Inhibitor
Date:11/8/2012

KING OF PRUSSIA, Pa., Nov. 8, 2012 /PRNewswire/ -- A high level of health-related quality of life (HRQoL) is achievable for patients managing hereditary angioedema (HAE), a rare and serious genetic disorder, when effective treatment such as C1-inhibitor (INH) concentrate is available, according to a prospective patient assessment published recently in Allergy & Asthma Proceedings, the official journal of Regional, State & Local Allergy, Asthma and Immunology Societies (RSLAAIS) and the American Association of Certified Allergists (AACA). More than half of the HAE patients participating in the assessment reported feeling somewhat or much better with the availability of C1-INH concentrate, and more than 80 percent of participants indicated a more optimistic outlook on the future.

"The unpredictability, pain and potentially life-threatening nature of acute HAE attacks has been shown to dramatically impact patients' health-related quality of life, but limited research has been conducted regarding their HRQoL while being treated for those attacks," said Timothy J. Craig, D.O., Professor of Medicine and Pediatrics at Penn State University in Hershey, Pennsylvania, and one of the study's investigators. "Based on our findings, the availability of C1-INH for the treatment of acute attacks of HAE appears to provide patients with a better outlook on the future and a greater level of security in disease treatment."

For people living with HAE, episodes of edema, or swelling, in various body locations, can have a significant impact on QoL. Patients who have abdominal attacks of HAE can experience episodes of extreme pain, diarrhea, nausea and vomiting caused by swelling of the intestinal wall. HAE attacks that involve the face or throat can result in airway closure, asphyxiation and, if untreated, death.

Study Design and Key Findings
The prospective patient assessment included a subset of 28 participants enrolled in the In
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SOURCE CSL Behring
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