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Analysis Compares Cost-Effectiveness of Premixed Insulin Analogs to Long-Acting Insulin Analogs in the Long-Term Treatment of Type 2 Diabetes in the U.S.
Date:6/24/2011

SAN DIEGO and INDIANAPOLIS, June 24, 2011 /PRNewswire/ -- Eli Lilly and Company (NYSE: LLY) today announced results from an analysis designed to evaluate the cost-effectiveness of insulin lispro mix 75/25 and insulin lispro mix 50/50 versus long-acting insulin analog (LAIA).

The analysis indicated that for patients with type 2 diabetes who do not experience frequent hypoglycemia, insulin lispro premixed insulin analogs are likely to be cost-effective when compared to LAIA in the long-term treatment of type 2 diabetes. The results were presented today at the Association's 71st Scientific Sessions in San Diego, CA. The study also will be featured at the President's Poster Session, a showcase featuring 100 outstanding posters selected by the Scientific Sessions Meeting Planning Committee.

The analysis further quantified a recent meta-analysis conducted by the Agency for Healthcare Research and Quality (AHRQ), which assessed the relative effectiveness and safety of premixed analog insulin and LAIA, finding that premixed insulin analogs may provide tighter glycemic control than long-acting alternatives.

A validated diabetes model was used to compare the cost effectiveness of insulin lispro premixed insulin analogs versus LAIA from a U.S. healthcare payer perspective.

Insulin lispro premixed insulin analogs were associated with improvements in both life expectancy (+0.07 and +0.09 years, respectively) and quality-adjusted life expectancy (+0.07 quality-adjusted life years [QALYs] and +0.08 QALYs, respectively) when compared with LAIA. These clinical benefits were accompanied by increases in direct lifetime costs of $1,724 and $1,720 relative to LAIA, yielding incremental cost-effectiveness ratios of $28,580 and $23,150 per QALY gained for the premixed insulin analogs versus LAIA, respectively.

To calculate the costs, the base case analysis was
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SOURCE Eli Lilly and Company
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