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Analyses Find Type 2 Diabetes Patients Treated with BYDUREON™ Experienced Reduction in Cardiovascular Risk Factors: Results Presented at EASD 2011
Date:9/12/2011

ions between these cardiovascular risk factors and body weight changes; and the percentage of patients achieving composite endpoint goals (A1C <7 or less than or equal to 6.5 percent plus systolic blood pressure <130 mmHg and LDL cholesterol <100 mg/dL).

DURATION-4
Presentation Number 779
Poster Session 062--Exenatide: twice daily to once weekly
Tuesday, Sept. 13, 2011, 1:30-2:30 p.m. Western European Summer TimeThe 26-week, double-blind, randomized, four-arm parallel study enrolled 820 drug-naive patients with type 2 diabetes and compared BYDUREON with metformin, Januvia and Actos monotherapies. The primary endpoint was reduction in A1C levels, while secondary endpoints included change in body weight along with other parameters of glucose control, cardiovascular health and patient-reported outcomes. 

The post-hoc analyses assessed change in cardiovascular risk factors; correlations between changes in risk factors and body weight for each treatment group; and the percentage of patients achieving composite goals (A1C <7 percent, no weight gain and no minor or major hypoglycemia; and A1C <7 percent, systolic blood pressure <130 mmHg and LDL cholesterol <100 mg/dL). At baseline, more than 50 percent of patients had abnormal blood pressure and lipids, except for total cholesterol.

About Diabetes Diabetes affects nearly 26 million people in the U.S. and an estimated 347 million adults worldwide.(i, ii) Approximately 90-95 percent of those affected have type 2 diabetes. In the U.S., diabetes costs more than $174 billion per year in direct and indirect medical expenses.(iii)

According to the Centers for Disease Control and Prevention's National Health and Nutrition Examination Survey, approximately 60 percent of people with diabetes do not achieve their target blood sugar levels with their current treatment regimen.(iv) In addition, 85 percent of type
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SOURCE Amylin Pharmaceuticals, Inc.; Eli Lilly and Company; Alkermes, Inc.
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