Navigation Links
Anadys Pharmaceuticals Resumes Clinical Investigation of TLR7 Mechanism in HCV
Date:7/7/2008

t few weeks and in HCV patients early in the fourth quarter of 2008.

About ANA773 and TLR Pharmacology

ANA773 is an orally administered prodrug of a novel TLR7-specific agonist. Results from pre-clinical pharmacology studies have shown that ANA773 can elicit desired immune responses and that the profile of response can be modulated by both dose and schedule of administration. Results of recently completed 13-week GLP toxicology studies have shown that with every-other-day dosing of ANA773, immune stimulation of a magnitude believed to confer therapeutic potential can be achieved without adverse toxicology findings. The immune stimulation observed with every-other-day dosing of ANA773 in monkeys included induction of interferon-alpha and interferon dependent responses at levels that are sustained over 13 weeks of dosing.

The recently obtained results with every-other-day dosing of ANA773 over 13 weeks contrast with results from prior 13-week animal toxicology studies that utilized daily dosing of ANA975, a TLR7 agonist prodrug previously in development by the Company for the treatment of chronic hepatitis C. In initial 13-week animal toxicology studies of ANA975 dosed daily, unexpected findings associated with intense immune stimulation were observed. When lower daily doses of ANA975 were then explored in a subsequent 13-week animal toxicology study, it was determined that adverse findings were present even at dose levels where desired immunostimulatory effects were not measurable, following which the decision was made in 2007 to discontinue development of ANA975.

Webcast of Conference Call

Anadys will host a conference call today, July 7, 2008 at 2:00 p.m. Pacific Daylight Time to discuss Anadys' plans to resume clinical investigation of the TLR7 mechanism in HCV. A live webcast of the call will be available online at http://www.anadyspharma.com. A telephone replay will also b
'/>"/>

SOURCE Anadys Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Anadys Pharmaceuticals Initiates Phase I Clinical Trial of ANA598
2. Anadys Pharmaceuticals Presents Data on ANA598, a Non-Nucleoside Inhibitor of the HCV Polymerase, at the 21st International Conference on Antiviral Research
3. Anadys Pharmaceuticals Announces Positive Results for ANA598 in Animal Model of Chronic Hepatitis C Virus Infection
4. Anadys Pharmaceuticals Presents Preclinical Results on ANA598, a Non-Nucleoside Inhibitor of the NS5B Polymerase, at the 14th International Symposium on Hepatitis C Virus and Related Viruses
5. University of Rochester Researcher Named Millennium Pharmaceuticals Career Development Scholar of The Leukemia & Lymphoma Society
6. Peregrine Pharmaceuticals Reports Positive Early Results in Phase II Study of Bavituximab in Breast Cancer
7. Isis Pharmaceuticals Conference Call Notice
8. Peregrine Pharmaceuticals Doses First Patient in Phase II Trial of Bavituximab in Patients With Non-Small Cell Lung Cancer
9. XTL Biopharmaceuticals Announces Completion of Patient Randomization Into the Bicifadine Phase 2b Clinical Trial for the Treatment of Diabetic Neuropathic Pain
10. MAP Pharmaceuticals Reports Positive Pharmacological Response Data for Migraine Product Candidate at the American Headache Society Annual Meeting
11. Phase III Data Show Vanda Pharmaceuticals Tasimelteon (VEC-162) Significantly Improves Sleep in Patients with Chronic Insomnia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... 2014 Today, iHealth Lab Inc. announced it has ... for its first institutional round of funding. The strategic ... reach, accelerate growth and innovation, and invest in additional ... Xiaomi Ventures will join iHealth,s board of directors, bringing ... ecommerce. "We are very pleased to have ...
(Date:9/19/2014)... , September 19, 2014 ... has announced the addition of the ... to their offering.      (Logo: ... been broadly classified into wide categories based ... for the treatment of different gynecological conditions ...
(Date:9/19/2014)... Ill. , Sept. 19, 2014  The board ... ) declared a quarterly cash dividend of $0.42 per ... Nov. 17, 2014 to stockholders of record at the ... About AbbVie AbbVie is a global, research-based biopharmaceutical company ... mission is to use its expertise, dedicated people and ...
Breaking Medicine Technology:iHealth Raises $25 Million to Fuel Growth and Global Market Share 2Global Gynecological Devices Market 2014-2018: Key Vendors are Bayer, Boston Scientific, CooperSurgical, Ethicon, Hologic, Medtronic, Olympus and Stryker 2Global Gynecological Devices Market 2014-2018: Key Vendors are Bayer, Boston Scientific, CooperSurgical, Ethicon, Hologic, Medtronic, Olympus and Stryker 3
... 2011 Reportlinker.com announces that a new market ... Global Microscopes Industry ... the worldwide markets for Microscopes in US$ Million ... Microscopes, and Scanning Probe Microscopes. The report also ...
... StemCyte, Inc. announces the launch of www.cordbloodtv.com , ... offers this comprehensive educational tool that allows audiences worldwide ... blood banking options and the latest in medical research ... "StemCyte is pleased to offer our worldwide ...
Cached Medicine Technology:Reportlinker Adds Global Microscopes Industry 2Reportlinker Adds Global Microscopes Industry 3Reportlinker Adds Global Microscopes Industry 4Reportlinker Adds Global Microscopes Industry 5Reportlinker Adds Global Microscopes Industry 6Reportlinker Adds Global Microscopes Industry 7Reportlinker Adds Global Microscopes Industry 8Reportlinker Adds Global Microscopes Industry 9Reportlinker Adds Global Microscopes Industry 10Reportlinker Adds Global Microscopes Industry 11Reportlinker Adds Global Microscopes Industry 12Reportlinker Adds Global Microscopes Industry 13Reportlinker Adds Global Microscopes Industry 14Reportlinker Adds Global Microscopes Industry 15Reportlinker Adds Global Microscopes Industry 16Reportlinker Adds Global Microscopes Industry 17Reportlinker Adds Global Microscopes Industry 18Reportlinker Adds Global Microscopes Industry 19Reportlinker Adds Global Microscopes Industry 20Reportlinker Adds Global Microscopes Industry 21Reportlinker Adds Global Microscopes Industry 22StemCyte Launches CordBloodTV 2
(Date:9/20/2014)... 20, 2014 Ticket Down is ... tickets. This popular ticket exchange is offering their customer ... is nearing that next step in the entertainment business. The ... in the music and entertainment business, but is closing in ... straight No. 1 album, will hit the road next year ...
(Date:9/20/2014)... 19, 2014 (HealthDay News) -- The avian flu that ... could be spread through respiratory drops and therefore poses ... study. Although no human illnesses have been linked ... Children,s Research hospital have discovered natural mutations to the ... travel through the air in droplets. Current seasonal ...
(Date:9/20/2014)... York, New York (PRWEB) September 20, 2014 ... power morcellators ( http://www.injurybeacon.com/power-morcellator/ ) in gynecological ... that yet another insurer has announced plans to ... statement posted on its website last month, Harrisburg, ... procedures effective November 1, 2014. The insurer said ...
(Date:9/20/2014)... PA (PRWEB) September 20, 2014 "As a ... in their tanks," said an inventor from Tamaqua, Pa. "The ... mounted on the backs of their chairs. My invention enables ... developed the Kam Oxygen Sensor to make it easier to ... that the user knows when the tank is low. It ...
(Date:9/20/2014)... 2014 RBSEO Services, which has occupied ... has announced it provides an affordable website SEO (Search ... This announcement would benefit those new and old businesses ... cannot afford to pay a big amount for their ... their websites in top search results for their business ...
Breaking Medicine News(10 mins):Health News:Ariana Grande Tickets in Chicago/Rosemont, Kansas City, Milwaukee, Saint Paul, Dallas, Houston, San Antonio, Oklahoma City Go On Sale Today 2Health News:Ariana Grande Tickets in Chicago/Rosemont, Kansas City, Milwaukee, Saint Paul, Dallas, Houston, San Antonio, Oklahoma City Go On Sale Today 3Health News:Avian Flu In Harbor Seals Could Infect People 2Health News:As Power Morcellator Concerns Grow, Bernstein Liebhard LLP Notes Another Insurer’s Decision to Drop Coverage for Uterine Morcellation 2Health News:As Power Morcellator Concerns Grow, Bernstein Liebhard LLP Notes Another Insurer’s Decision to Drop Coverage for Uterine Morcellation 3Health News:RBSEO Services Announces Affordable Website SEO Service at Only $175 2
... CHICAGO Results of clinical research on new presbyopia treatments ... the United Stateswere reported in today,s Scientific Program of ... Ophthalmology (AAO) and Middle East-Africa Council of Ophthalmology ... comprehensive ophthalmic education conference and is in session October ...
... the world of business-performance experts and baseball talent scouts, ... to find a way to measure the productivity of ... findings the most recent issue of Science Translational ... contributions of individual scientists, judging the effectiveness of team ...
... By Serena Gordon HealthDay Reporter , MONDAY, ... average, untrained person can still save a life by focusing ... Heart Association. The simplified form of cardiopulmonary resuscitation, or ... -- and the oxygen in the blood -- flowing to ...
... HealthDay Reporter , MONDAY, Oct. 18 (HealthDay News) -- ... non-heart surgery had a higher risk of death in the ... found. And, patients who hadn,t been diagnosed with diabetes ... higher risk of death in the year after a surgical ...
... cancers can be divided into different subtypes based on ... protein to which the female hormone estrogen binds; that ... tumors have a worse outlook than those with ER-positive ... characterized as basal-like are the most aggressive and difficult ...
... American descent Latinas - from using cancer screening ... Dr. Linda Gallo from San Diego State University in ... are pessimistic about preventive health practices and disease outcomes ... breast and colorectal cancer. The research is published online ...
Cached Medicine News:Health News:New vision correction options for baby boomers 2Health News:New vision correction options for baby boomers 3Health News:New vision correction options for baby boomers 4Health News:Is team science productive? 2Health News:Is team science productive? 3Health News:New CPR Guidelines Emphasize Compressions First 2Health News:New CPR Guidelines Emphasize Compressions First 3Health News:Even Well-Controlled Diabetes May Present Post-Surgery Risk 2Health News:Even Well-Controlled Diabetes May Present Post-Surgery Risk 3Health News:Latinas: 'Cancer was just meant to be' 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: