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Anadys Pharmaceuticals Presents Preclinical Results on ANA598, a Non-Nucleoside Inhibitor of the NS5B Polymerase, at the 14th International Symposium on Hepatitis C Virus and Related Viruses
Date:9/11/2007

ficer of Anadys. "In chronic viral diseases, achieving blood levels in preclinical studies that are many-fold above concentrations needed for viral suppression is generally recognized as a predictor of potential clinical utility."

In June, Anadys announced the nomination of ANA598 as a clinical development candidate. ANA598 was selected from the Company's internal NS5B discovery efforts based on an optimized balance of preclinical properties and was the result of the Company's structure-based drug design capabilities. ANA598 is undergoing IND enabling activities and an IND submission is targeted for the first half of 2008.

"After completing the necessary IND enabling studies, we look forward to exploring the potential clinical utility of ANA598 in patients with HCV," said James Freddo, MD, Anadys' Chief Medical Officer. "Based on the combined potency, pharmacokinetic and preliminary toxicologic properties of ANA598, we believe that this is an exciting new direct antiviral to investigate for the treatment of patients with hepatitis C virus infection."

About Anadys

Anadys Pharmaceuticals, Inc. is a biopharmaceutical company committed to advancing patient care by developing and commercializing novel small molecule medicines for the treatment of hepatitis C virus (HCV) infection and cancer. The Company is developing ANA598, a small-molecule, non-nucleoside inhibitor of the NS5B polymerase for the treatment of HCV and ANA773, an oral TLR7 agonist prodrug for cancer.

Safe Harbor Statement

Statements in this press release that are not strictly historical in nature constitute "forward-looking statements." Such statements include, but are not limited to, references to the expected timing and planned development activities for ANA598, the prediction that ANA598 has a low likelihood of producing clinical drug-drug interactions, the use of doses in preclinical studies that are designed to be predictive of human doses, the belief that achievin
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