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Anadys Pharmaceuticals Announces Successful Outcome of ANA598 Healthy Volunteer Study and Finalization of Study Design for Phase Ib Trial in HCV Patients
Date:9/24/2008

and continuous development path into Phase II studies during 2009.

ANA598 Data to be Presented at AASLD Meeting

Anadys will present data on ANA598 during three poster sessions at the 59th Annual Meeting of the AASLD, to be held in San Francisco, California, October 31 - November 4, 2008. The full abstracts, which are summarized below, can be viewed at the AASLD website at http://www.aasld.org.

Anadys will present a late-breaker poster at a session beginning at 8:00 a.m. PST on Monday, November 3. The poster, titled "Results of a Phase I Safety, Tolerability and Pharmacokinetic Study of ANA598, a Non-Nucleoside NS5B Polymerase Inhibitor, in Healthy Volunteers", will present data from the first clinical study of ANA598.

Two additional posters will be presented on Tuesday, November 4, 2008:

-- In a poster titled "Antiviral Efficacy of the HCV RNA Polymerase Inhibitor ANA598 in the Chimpanzee Model of HCV Infection", Anadys will present data showing that ANA598 exhibits a substantial antiviral effect against both genotype 1a and 1b virus in HCV-infected chimpanzees. ANA598 was given as single and multiple oral doses and was well-tolerated in the study.

-- In a poster titled "In Vitro Studies Demonstrate that Combinations of Antiviral Agents that Include HCV Polymerase Inhibitor ANA598 have the Potential to Overcome Viral Resistance", Anadys will present the results of in vitro studies that show ANA598 to be strongly synergistic with interferon-alpha. These studies also show that ANA598 retains activity against mutants known to confer resistance to other classes of direct antivirals, including protease inhibitors, nucleoside inhibitors and non-nucleosides that bind at the thumb site. In addition, genotypic mutations resistant to ANA598 will be presented and shown to be fully susceptible to interferon-alpha, a representative protease inhibitor and a representative nucleoside polyme
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SOURCE Anadys Pharmaceuticals, Inc.
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