Navigation Links
Anadys Pharmaceuticals Announces Successful Outcome of ANA598 Healthy Volunteer Study and Finalization of Study Design for Phase Ib Trial in HCV Patients
Date:9/24/2008

ed to display substantial antiviral activity based on preclinical results. Additionally, absorption was enhanced when ANA598 was taken with food, indicating that it should not be necessary to take ANA598 on an empty stomach in order to achieve desired plasma drug levels.

Additional detail from the Phase I study, including full PK results from the twice-daily 800 mg cohort, will be presented at the 59th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD), to be held in San Francisco, California, October 31 - November 4, 2008. Abstracts can be viewed at the AASLD website at http://www.aasld.org.

ANA598 Program Update

Anadys is now finalizing preparations to begin a Phase Ib trial of ANA598 in HCV patients early in the fourth quarter. The study will be conducted at several sites in the United States. The regulatory review necessary to initiate the study has been completed. In the Phase Ib monotherapy study, naive genotype 1 patients will receive ANA598 over three days, at doses of 200 mg bid, 400 mg bid or 800 mg bid. Ten patients are planned to be enrolled in each of the three cohorts, eight on active treatment and two on placebo. Anadys expects to have viral load data from all three cohorts in the first quarter of 2009. Anadys may elect to explore other dose levels of ANA598 and/or once-daily dosing in this study, depending on data from the first three cohorts.

In September, Anadys initiated long-term chronic toxicology studies of ANA598. As communicated in April of this year, Anadys made the strategic decision to accelerate into 2008 certain non-clinical activities for the ANA598 program, including the initiation of these long-term toxicology studies and the manufacture of additional drug substance. If ANA598 is successful in early stage clinical trials, it is anticipated that the acceleration of these non-clinical activities into 2008 will enable a more rapid
'/>"/>

SOURCE Anadys Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4 5 6

Related medicine technology :

1. Anadys Pharmaceuticals Resumes Clinical Investigation of TLR7 Mechanism in HCV
2. Anadys Pharmaceuticals Initiates Phase I Clinical Trial of ANA598
3. Anadys Pharmaceuticals Presents Data on ANA598, a Non-Nucleoside Inhibitor of the HCV Polymerase, at the 21st International Conference on Antiviral Research
4. Anadys Pharmaceuticals Announces Positive Results for ANA598 in Animal Model of Chronic Hepatitis C Virus Infection
5. Anadys Pharmaceuticals Presents Preclinical Results on ANA598, a Non-Nucleoside Inhibitor of the NS5B Polymerase, at the 14th International Symposium on Hepatitis C Virus and Related Viruses
6. Oramed Pharmaceuticals Commences Phase 2A Trials of its Oral Insulin Capsule on Type 1 Diabetics
7. Vion Pharmaceuticals Enters into Agreement to Conduct a Phase I/II Clinical Trial of Cloretazine(R) in Combination with Induction Therapy in Poor Prognosis AML Patients
8. Memory Pharmaceuticals and Roche Expand R3487/MEM 3454 Development Program
9. Oramed Pharmaceuticals Launches GLP1-Analog Program, Based on its Proprietary Drug Delivery Platform
10. Cadence Pharmaceuticals Updates Omigard(TM) Clinical Timeline
11. VIA Pharmaceuticals to Present at American Heart Association Scientific Sessions 2008
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/16/2009)... A new application developed by American ... of specialty pharmaceuticals has increased health plan staff ... reducing costs. ,, AIM, a leading diagnostic imaging ... clients representing over 35 million consumers and an ... WLP ), adapted the successful clinical and technology ...
(Date:12/16/2009)... Technologies, Inc. (Pink Sheets: AVXT) ("AVAX" or the ... bridge loan financing (the "2009 Financing") pursuant to ... "Agreement") with Firebird Global Master Fund, Ltd., ("Firebird"). ... convertible promissory note, due June 30, 2010, in ... a warrant to purchase an aggregate of 93,333,333 ...
(Date:12/16/2009)... Dec. 16 Boston Scientific Corporation (NYSE: ... of Directors has elected Nelda Connors as a Director. ... the Electrical and Metal Products division of Tyco International. ... Corporation, holding several positions in operations and general management. ... a number of executive and management capacities with Ford, ...
Breaking Medicine Technology:American Imaging Management's New Specialty Drug Program Delivers Immediate Results 2American Imaging Management's New Specialty Drug Program Delivers Immediate Results 3American Imaging Management's New Specialty Drug Program Delivers Immediate Results 4AVAX Technologies, Inc. Closes Bridge Financing 2AVAX Technologies, Inc. Closes Bridge Financing 3AVAX Technologies, Inc. Closes Bridge Financing 4Boston Scientific Announces Election of Nelda Connors to Its Board of Directors 2Boston Scientific Announces Election of Nelda Connors to Its Board of Directors 3Savient Pharmaceuticals Reports Third Quarter 2009 Financial Results 6000 1Savient Pharmaceuticals Reports Third Quarter 2009 Financial Results 6000 2Savient Pharmaceuticals Reports Third Quarter 2009 Financial Results 6000 3Savient Pharmaceuticals Reports Third Quarter 2009 Financial Results 6000 4Savient Pharmaceuticals Reports Third Quarter 2009 Financial Results 6000 5Savient Pharmaceuticals Reports Third Quarter 2009 Financial Results 6000 6Savient Pharmaceuticals Reports Third Quarter 2009 Financial Results 6000 7Savient Pharmaceuticals Reports Third Quarter 2009 Financial Results 6000 8Savient Pharmaceuticals Reports Third Quarter 2009 Financial Results 6000 9Savient Pharmaceuticals Reports Third Quarter 2009 Financial Results 6000 10Savient Pharmaceuticals Reports Third Quarter 2009 Financial Results 6000 11Savient Pharmaceuticals Reports Third Quarter 2009 Financial Results 6000 12Savient Pharmaceuticals Reports Third Quarter 2009 Financial Results 6000 13Savient Pharmaceuticals Reports Third Quarter 2009 Financial Results 6000 14Professor Steven Ley of University of Cambridge will Present Free Webinar 26apos 3BApplication of the ReactIR Flow Cell to Continuous Processing Tec 14728 1Professor Steven Ley of University of Cambridge will Present Free Webinar 26apos 3BApplication of the ReactIR Flow Cell to Continuous Processing Tec 14728 2Professor Steven Ley of University of Cambridge will Present Free Webinar 26apos 3BApplication of the ReactIR Flow Cell to Continuous Processing Tec 14728 3COTR Refresher Course Offered 11 January 2010 28Wash DC Area 29 60727 1COTR Refresher Course Offered 11 January 2010 28Wash DC Area 29 60727 2COTR Refresher Course Offered 11 January 2010 28Wash DC Area 29 60727 3
(Date:12/16/2009)... -- For wounded U.S. servicemen and women ... D.C., the holidays can be a particularly difficult time. ... rely more than ever on the healing power of ... home just got easier for Walter Reed patients as ... will provide hundreds of minutes of holiday talk time ...
(Date:12/16/2009)... possibly deadly, attack is long-term goal, researchers say ... developed a tool to predict whether a patient will ... first stroke. , "This is an important new tool ... second stroke soon after a first stroke are more ... Ay, of Massachusetts General Hospital and Harvard Medical School, ...
(Date:12/16/2009)... that could help ease health and environmental concerns about ... technology for changing the behavior of nanoparticles in municipal ... environment. Their study was published in ACS, journal ... the UK Centre for Ecology and Hydrology and colleagues ... of nanoparticles particles less than 1/1000th the width ...
(Date:12/16/2009)... Cost-Effective Care , ... Washington, D.C. (Vocus) December 16, ... ways to rein in runaway costs while providing care to all ... the ongoing discussion includes how to ensure patients equal access to ... (MDs) or osteopathy (DOs). In both the House and Senate ...
(Date:12/16/2009)... Specific Neurological Stress Reduction Therapy or NSRTSM is found very ... conditions such as allergies, asthma, migraines, chronic fatigue and a ... throughout the country are using this holistic therapy including over ... ... Minneapolis, MN (Vocus) December 14, 2009 -- ...
Breaking Medicine News(10 mins):Health News:Verizon Wireless Donates $10,000 in Long-Distance Calling Cards to Soldiers at Walter Reed Hospital 2Health News:New Stroke Tool May Predict Early Recurrence 2Health News:Behavior modification could ease concerns about nanoparticles 2Health News:Coalition for Patients' Rights: Access to Broad Range of Health Care Providers Critical to Lowering Costs 2Health News:Coalition for Patients' Rights: Access to Broad Range of Health Care Providers Critical to Lowering Costs 3Health News:Coalition for Patients' Rights: Access to Broad Range of Health Care Providers Critical to Lowering Costs 4Health News:Coalition for Patients' Rights: Access to Broad Range of Health Care Providers Critical to Lowering Costs 5Health News:BioVeda Health and Wellness Center of Chanhassen, MN Announces Its Grand Opening 2Health News:BioVeda Health and Wellness Center of Chanhassen, MN Announces Its Grand Opening 3Health News:BioVeda Health and Wellness Center of Chanhassen, MN Announces Its Grand Opening 4Health News:BioVeda Health and Wellness Center of Chanhassen, MN Announces Its Grand Opening 5
... LAB) announces the following Webcast:, What: Second Quarter 2008 ... Eastern Time, 11:00 am ... Live over the Internet -- Simply log on to the web at ... Contact: Maria Barona of i-advize Corporate Communications, Inc., ...
... In two complementary studies, Weizmann Institute scientists have developed ... and have applied this technique to trace the history ... understand a cell,s path of descent, called a cell ... and medicine as gleaning such knowledge is key to ...
... Scientists at Georgia Tech have developed a potential new treatment ... them to be captured and carried out of the body. ... and will now be looked at in survival studies, is ... Society . , "We,ve been able to use magnetic nanoparticles ...
... and lifestyle changes can head off threats like heart attack ... one in three Americans suffers from high blood pressure -- ... -- women -- face unique challenges in controlling their blood ... more likely to be obese and have high cholesterol levels. ...
... ATLANTA, July 16 MDdatacor, Inc., a leader ... and providers, today,announced the appointment of Gregory A. ... officer. In this new role, Buchholz will be,responsible ... Buchholz will oversee the quality assurance, project management,informatics, ...
... provides an innovative branded community to help coordinate ... ... July 16 CareGiverHelper, a provider of,social networking solutions/portals for ... to Ceridian LifeWorks, a,leading provider of health and productivity services ...
Other Medicine News:Health News:Weizmann Institute scientists' new technique gets to the root of cancer 2Health News:Weizmann Institute scientists' new technique gets to the root of cancer 3Health News:Using magenetic nanoparticles to combat cancer 2Health News:Many Women Struggle With Uncontrolled Blood Pressure 2Health News:Many Women Struggle With Uncontrolled Blood Pressure 3Health News:Many Women Struggle With Uncontrolled Blood Pressure 4Health News:MDdatacor Names Gregory Buchholz Chief Operating Officer 2Health News:Ceridian LifeWorks Offers CareGiverHelper Service to Clients to Ease Stress of Family Caregiving 2Health News:Ceridian LifeWorks Offers CareGiverHelper Service to Clients to Ease Stress of Family Caregiving 3
... Exp Expandable Tip System A ... System allows you to perform multi-sample transfers between ... pull of a knob, tip spacing can be ... microcentrifuge tubes) or 96 well plates. Ergonomic ...
... Exp Expandable Tip System A ... System allows you to perform multi-sample transfers between ... pull of a knob, tip spacing can be ... microcentrifuge tubes) or 96 well plates. Ergonomic ...
... Exp Expandable Tip System A lower ... allows you to perform multi-sample transfers between two ... of a knob, tip spacing can be quickly ... tubes) or 96 well plates. Ergonomic Design ...
... Exp Expandable Tip System A lower ... allows you to perform multi-sample transfers between two ... of a knob, tip spacing can be quickly ... tubes) or 96 well plates. Ergonomic Design ...
Medicine Products: