Navigation Links
Amylin to Present Data Showing Investigational Metreleptin Treatment Led to Long-Term Improvements in Diabetes and Lipid Control in Patients with Lipodystrophy
Date:4/15/2011

isk for serious medical problems such as acute pancreatitis, accelerated atherosclerosis, and blood vessel and nerve damage from diabetes and liver cirrhosis, which can markedly reduce quality of life and life expectancy. Metreleptin works to treat metabolic abnormalities in patients with lipodystrophy.

It is estimated that there are a few thousand patients worldwide with this condition, although robust epidemiological data are not available, as is common with rare diseases. There are no therapies currently indicated specifically for the treatment of metabolic abnormalities associated with lipodystrophy. Presently, patients may receive a combination of dietary modification, anti-diabetic medications and lipid-lowering agents. These traditional treatment approaches do not address the underlying cause of the metabolic abnormalities in lipodystrophy and are often rendered marginally effective due to the severity of the condition.

About Metreleptin for Lipodystrophy

Data from clinical studies conducted by investigators at the NIH and other academic institutions in the U.S., Europe and Japan, have demonstrated that metreleptin can have profound effects on improving insulin sensitivity, high trigylcerides, hyperglycemia and liver fat in patients with lipodystrophy who are not responsive to conventional lipid and glucose-lowering agents, even those undergoing intensive insulin therapy.

Globally, approximately 150 patients with lipodystrophy are being treated with metreleptin under investigator-sponsored trials and expanded access programs.

In 2010, Amylin submitted the non-clinical and clinical sections of a rolling submission for a Biologics License Application (BLA) to the U.S. Food and Drug Administration (FDA) for the use of metreleptin to treat diabetes and/or hypertriglyceridemia in patients with rare inherited or acquired forms of lipodystrophy. The Company plans to submit the chemistry, manufacturing and controls (CMC) se
'/>"/>

SOURCE Amylin Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Amylin Pharmaceuticals Initiates Phase 2B Dose-Ranging Clinical Study of Pramlintide/Metreleptin Combination Treatment in Obesity
2. Amylin Pharmaceuticals to Present Novel Data on Promising Obesity Pipeline at 2008 Annual Scientific Meeting of The Obesity Society
3. Amylin and Lilly Announce Plans to Develop Pen Device for Exenatide Once Weekly
4. Amylin Pharmaceuticals Highlights New Data Supporting Therapeutic Potential of Obesity Pipeline at Obesity 2009
5. Amylin Pharmaceuticals Reports Third Quarter Financial Results
6. Amylin Pharmaceuticals and Eli Lilly and Company Statement on FDAs BYETTA(R) (Exenatide) Injection Update
7. Amylin Pharmaceuticals to Present at the 18th Annual Credit Suisse Healthcare Conference
8. Amylin Pharmaceuticals to Webcast Year-End Financial Results
9. Amylin Highlights 2010 Corporate Priorities at J.P. Morgan Healthcare Conference
10. Amylin and Takeda Announce Decision to Advance Development of Pramlintide/Metreleptin Combination Treatment for Obesity
11. Amylin Pharmaceuticals to Present at The Barclays Capital 2010 Global Healthcare Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2015)... and ST. LOUIS , ... blood pressure or high cholesterol may achieve better health ... networks, according to early results of a unique program ... ESRX ). "Pharmacists are one of ... frequent interactions with our members presents enormous opportunities to ...
(Date:5/5/2015)... Lymphatic pump treatment (LPT) shows promise in ... a new study published in The Journal of ... performed LPT on infected rats three times a day ... to treat pneumonia. After 96 hours, over 60 percent ... 25 percent of rats who received levofloxacin alone. ...
(Date:5/5/2015)... PORTLAND, Oregon , May 5, 2015 ... market in the US, Europe , ( ... , Spain , UK) and ... and etiology are reviewed. The report provides the 5-year test volume ... Ag, HCV, HCV NAT, Anti-HBc, Anti-HBs, Anti-HAV, Hepatitis Delta, HBc Ag, ...
Breaking Medicine Technology:SCAN Health Plan, Express Scripts' Quality Network Improves Medicare Beneficiary Health 2SCAN Health Plan, Express Scripts' Quality Network Improves Medicare Beneficiary Health 3SCAN Health Plan, Express Scripts' Quality Network Improves Medicare Beneficiary Health 4Lymphatic Pump Treatment Enhances Antibiotic Effectiveness for Treating Pneumonia 22015 Opportunities in the Global Hepatitis Diagnostic Testing Market: Big Market Research 22015 Opportunities in the Global Hepatitis Diagnostic Testing Market: Big Market Research 3
(Date:5/5/2015)... May 05, 2015 The global lab ... 2020 from $3,474.2 Million in 2014, at an estimated ... segments the lab automation market on the basis of ... and region. On the basis of application, Lab Automation ... solutions, and proteomics solutions. Drug discovery is a major ...
(Date:5/5/2015)... May 05, 2015 Viverae®, a ... Bard Inc., a leading multinational developer, manufacturer and ... fields of vascular, urology, oncology and surgical specialty ... Award. The Vanguard Award recognizes outstanding achievement ... programs among Viverae’s significant client base. , Viverae ...
(Date:5/5/2015)... Dr. Patricia George knows all too well the ... pulmonary hypertension specialist at the University of Pittsburgh Medical ... an initial idea entered her mind for Team PHenomenal ... at the 2010 PHA International Conference,” George recalled. “The ... recalling their climb up Mt. Kilimanjaro and I remember ...
(Date:5/5/2015)... In a April 25, 2015, report published in ... Missouri State Highway Patrol (MSHP) announced that Indiana led the ... the second year in a row. , The MSHP, ... incidents in 2014 alone, around 15% of the national total. ... US Population calls Indiana home, according to the report. , ...
(Date:5/5/2015)... York, NY (PRWEB) May 05, 2015 ... Platform that enables businesses to deploy Mobile Engagement Campaigns ... Constant Contact . ProTexting clients can now leverage the ... reach by collecting and syncing subscribers’ e-mail addresses into ... says “We have recognized that the growing trend of ...
Breaking Medicine News(10 mins):Health News:Global Lab Automation Market Forecast to 2020: Research Based on Equipment & Software, Applications, Type of Automation and End Users 2Health News:Global Lab Automation Market Forecast to 2020: Research Based on Equipment & Software, Applications, Type of Automation and End Users 3Health News:Global Lab Automation Market Forecast to 2020: Research Based on Equipment & Software, Applications, Type of Automation and End Users 4Health News:Global Lab Automation Market Forecast to 2020: Research Based on Equipment & Software, Applications, Type of Automation and End Users 5Health News:Viverae® Honors C. R. Bard, Inc. with 2015 Vanguard Award 2Health News:World PH Day: Team PHenomenal Hope Races to Spread the Word about Pulmonary Hypertension 2Health News:A Forever Recovery Releases New Information on the Epidemic Rise Of Methamphetamine Abuse in Midwest America 2Health News:ProTexting SMS Mobile Marketing platform integrates with Constant Contact 2Health News:ProTexting SMS Mobile Marketing platform integrates with Constant Contact 3
... occurs in sperm could be the key to a new ... an ion channel protein that controls the flow of calcium ... swim, so a drug designed to block the channel would ... in this week's Nature by Dr Arnold Clapham, from the ...
... cell disease is an inherited blood disorder that affects ... red blood cells that contain an abnormal type of ... have difficulty passing through small blood vessels. When sickle-shaped ... is often pain severe enough to require hospital admission. ...
... intestine could hold the key to permanent weight loss. ... is produced in the small intestine in response to ... development of better treatments for eating disorders and obesity. ... and profoundly different from those of traditional appetite suppressants. ...
... that tend to be slightly elevated but still considered ... for suffering from heart disease. Blood pressure readings are ... first number in a blood pressure measurement, represents the ... the diastolic value, represents the pressure when the heart ...
... be mindful of the possible interaction between oral ... Centers for Disease Control and Prevention (CDC) to ... and anti-infective medications, such as Cipro, doxycycline, and ... have been exposed to anthrax spores.// Many antibiotics ...
... significant breakthrough, a team of scientists have successfully transplanted ... diseased one, bringing light to the people who nearly ... about stem cells, in all 33 patients who suffered ... drug and auto-immune diseases causing damage to the part ...
Cached Medicine News:
For the quantitative determination of total protein in serum. Linearity: 1-15 g/dl....
... the quantitative determination of urea ... lag phase of less than ... phase of at least 240 ... 100 mg/dL (35.6 mmol/L urea) ...
For the quantitative determination of direct bilirubin in human serum. Linearity: 20 mg/dl...
For the quantitative determination of direct & total bilirubin in serum. Modified Malloy-Evelyn Diazotization Method. Endpoint Reaction Product measured at 540 nm. Linearity: 20 mg/dl...
Medicine Products: