Navigation Links
Amylin Pharmaceuticals to Present Novel Data on Promising Obesity Pipeline at 2008 Annual Scientific Meeting of The Obesity Society
Date:10/1/2008

proximately 8,000 individuals have received pramlintide in clinical trials, including more than 950 in obesity studies. Metreleptin (methionyl recombinant leptin; r-metHuLeptin) is an analog of human leptin, a neurohormone secreted by fat cells that plays a fundamental role in the regulation of energy metabolism and body weight. To date, more than 1,200 overweight or obese individuals have received metreleptin in clinical trials, several of which were 16 weeks or longer in duration.

Preclinical and clinical evidence published recently in PNAS, Proceedings of the National Academy of Sciences of the United States of America, demonstrates that, when pramlintide and metreleptin are administered in combination, leptin responsiveness is at least partially restored by amylin agonism. Experiments in diet-induced obese rats co-administrated with amylin and leptin resulted in synergistic reductions in food intake (up to 45%) and body weight (up to 15%), effects considerably greater than with leptin or amylin treatment alone. Weight loss with amylin/leptin treatment was fat- specific, and not accompanied by a reduction in lean mass. Translational clinical research confirms that findings in the non-clinical experiments are relevant to human obesity and suggest that metreleptin and pramlintide may be effective partners to pramlintide in the treatment of obesity. The most common side effects with the pramlintide/metreleptin combination treatment were injection site adverse events and nausea, which were mostly mild to moderate and transient in nature.

Important Safety Information for SYMLIN(R)

SYMLIN is not intended for all patients with diabetes. SYMLIN is used with insulin and has been associated with an increased risk of insulin-induced severe hypoglycemia, particularly in patients with type 1 diabetes. When severe hypoglycemia associated with SYMLIN use occurs, it is seen within three hours following a SYMLIN injection. If severe hypoglycemia occurs while
'/>"/>

SOURCE Amylin Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Amylin Pharmaceuticals Initiates Phase 2B Dose-Ranging Clinical Study of Pramlintide/Metreleptin Combination Treatment in Obesity
2. Transcept Pharmaceuticals Submits New Drug Application for Intermezzo(R) for Treatment of Middle-of-the-Night Awakenings
3. Critical Pharmaceuticals Enter Sustained Release hGH Arena
4. Anadys Pharmaceuticals to Present at the JMP Securities Healthcare Focus Conference
5. Potentia Pharmaceuticals Announces Positive Safety Data and Study Expansion in Phase I Trial for Lead Drug Candidate POT-4
6. Quark Pharmaceuticals Announces First RNAi Drug Candidate Having a Novel, Proprietary Structure Covered by Quark Intellectual Property
7. Lotus Pharmaceuticals, Inc.s New Drug Laevo-Bambutero Begins Evaluation for Clinical Trials
8. VIA Pharmaceuticals Completes Patient Visits in Phase 2 Acute Coronary Syndrome (ACS) Trial
9. QuatRx Pharmaceuticals Announces Additional Data From Phase 3 Study for Ophena(TM) (Ospemifene Tablets) Showing Improvements in Clinical Symptoms of Vulvovaginal Atrophy
10. Anadys Pharmaceuticals Announces Successful Outcome of ANA598 Healthy Volunteer Study and Finalization of Study Design for Phase Ib Trial in HCV Patients
11. Oramed Pharmaceuticals Commences Phase 2A Trials of its Oral Insulin Capsule on Type 1 Diabetics

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/25/2009)...ILL,N.C.,Nov.25/PRNewswire/--CempraPharmaceuticals...ntandchiefexecutiveofficer,willpresentatthePiperJa...ecember1,2009,atTheNewYorkPalaceHotelinNewYorkCity...oleadingantibioticclinicalprogramsforthetreatmento...tCempraPharmaceuticals ,, Foundedin2006,Cempra...
(Date:11/25/2009)...NVIEW,Calif.,Nov.25/PRNewswire/-- ChemoCentryx,In...eCompany,sPROTECT-1(theProspectiveRandomizedOralTh...(TM)(CCX282-B)inpatientswithmoderate-to-severeCroh...lesafetyandtolerabilityprofile.Thestudydemonstrate...severityasdefinedasa70-pointdecreaseintheCrohn,sDi...
(Date:11/24/2009)...,Calif.,Nov.24/PRNewswire-FirstCall/--Vermillion,I...ditsPlanofReorganizationandDisclosureStatementtoda...rtfortheDistrictofDelaware.Ahearingtoconsiderappro...December8,2009,withthehearingontheconfirmationofth...fortheCompanytopayallclaimsinfull.ThePlanisexpecte...
Breaking Medicine Technology:ChemoCentryx Reports Positive PROTECT-1 Study Results for Traficet-EN(TM) at the GASTRO 2009 UEGW/WCOG Conference 2ChemoCentryx Reports Positive PROTECT-1 Study Results for Traficet-EN(TM) at the GASTRO 2009 UEGW/WCOG Conference 3ChemoCentryx Reports Positive PROTECT-1 Study Results for Traficet-EN(TM) at the GASTRO 2009 UEGW/WCOG Conference 4ChemoCentryx Reports Positive PROTECT-1 Study Results for Traficet-EN(TM) at the GASTRO 2009 UEGW/WCOG Conference 5Vermillion Files Plan of Reorganization 2Vermillion Files Plan of Reorganization 3Wyeth Announces Holder Right to Surrender Convertible Debentures 12653 1Wyeth Announces Holder Right to Surrender Convertible Debentures 12653 2Wyeth Announces Holder Right to Surrender Convertible Debentures 12653 3Wyeth Announces Holder Right to Surrender Convertible Debentures 12653 4Torn Surgical Gloves Put Patients at Risk for Infection 49069 1Torn Surgical Gloves Put Patients at Risk for Infection 49069 2Providing health insurance for US children would be cheaper than expected study says 49065 1Providing health insurance for US children would be cheaper than expected study says 49065 2
...NEW YORK, July 12, 2007 /PRNewswire-FirstCall/ -- ...ibb Company today,announced results from an open-l...s a taxane and carboplatin in the first-line,treat...CLC). The,study did not meet its primary endpoint ...an independent radiology review,committee (IRRC). ...
... Helen Londe, M.D. Contributing Editor , ,Ce...sease of the small intestine that is triggered in ...f the gluten-containing grains wheat, rye, barley,...sult from the activation of both a T-cell and B-ce...n, villous atrophy, and crypt hyperplasia, and is ...
Other Medicine Technology:Data Available From Erbitux Phase III Study in First-Line Treatment,of Advanced Lung Cancer 2Data Available From Erbitux Phase III Study in First-Line Treatment,of Advanced Lung Cancer 3Data Available From Erbitux Phase III Study in First-Line Treatment,of Advanced Lung Cancer 4Data Available From Erbitux Phase III Study in First-Line Treatment,of Advanced Lung Cancer 5Data Available From Erbitux Phase III Study in First-Line Treatment,of Advanced Lung Cancer 6Data Available From Erbitux Phase III Study in First-Line Treatment,of Advanced Lung Cancer 7Data Available From Erbitux Phase III Study in First-Line Treatment,of Advanced Lung Cancer 8Data Available From Erbitux Phase III Study in First-Line Treatment,of Advanced Lung Cancer 9Non-Invasive Diagnostic Tests for Celiac Disease 2Non-Invasive Diagnostic Tests for Celiac Disease 3
(Date:11/26/2009)... strains or worse , , THURSDAY, Nov. 26 ...h stuffing your turkey full to bursting, but you m...ase as you pack for holiday trips. , More than ...l emergency rooms, doctors, offices, clinics and o...es, such as muscle strains, pulls and tears, accor...
(Date:11/26/2009)...ollercoaster, study finds , , THURSDAY, ...r meets the jubilant sports fan. , A new study ...oot for the winning team -- enjoy the greatest sat...ctory was in doubt, producing feelings of worry an...g weekend as you,re glued to the TV set, watching ...
(Date:11/26/2009)...the North Pole, Textsanta.net lets parents sign up... North Pole, AK (PRWEB) -- In a...he North Pole Santa Claus has added SMS text messa...rmed of his Christmas progress at the North Pole.,...e identified a large and growing percentage of Ame...
(Date:11/26/2009)...Live Life Again Center, a practice offering weigh...ber of physicians who are taking advantage of pop...iduals who are interested in surgical weight loss ...izing Facebook to share before-and-after photos an...y. , Dallas, TX (Vocus) N...
(Date:11/26/2009)...tal (RTDental), a leading dental group practice in...sion of its services to include LUMINEERS by a cer... Durham, NC (PRWEB) -- Res...Dr. Doug Macmillan, an experienced LUMINEERS Den...aining seminar. RTDental’s ability to fulfi...
Breaking Medicine News(10 mins):Health News:Pack Right for the Holidays to Avoid the ER 2Health News:Watching the Nail-Biting Big Game Hurts So Good 2Health News:Watching the Nail-Biting Big Game Hurts So Good 3Health News:Text Messages from Santa | Santa goes GREEN by going MOBILE for The March of Dimes 2Health News:Dallas Texas Weight Loss Surgeon Using Social Media To Reach Out to Patients 2Health News:Dallas Texas Weight Loss Surgeon Using Social Media To Reach Out to Patients 3Health News:Dr. Douglas Macmillan Now Providing LUMINEERS at Research Triangle Dental 2
... the thickness of the grey matter in the cortical ...ed thinning// of cortical region of the brain. Mai...rain is necessary for the proper functioning of th...ive and emotional processing, the researchers repo...
...educe world energy demand should it evolve into a ...ibly by more than 1-million barrels a day//. Wo...ording to data issued by the US Energy Information...by well over 1-million barrels per day,” the US in...
... a Singaporean, who had a bone marrow transplant i...ant operation without taking drugs to prevent reje... kidney failure four years ago. Two years later, d... Department of Medicine (NUH), "MDS is a pre-leuke...
...d are advised to be consumed; in the same league a...rient supplements help fight cancer even though th...particularly when you want to sell nutrition suppl...ion, helped save his neighbor known as “D.H.” with...
...d of trauma care are very few compared to other me...are would help in improving emergency treatments a...f deaths caused by accidents//. More than 10,...s, writing in this week's BMJ, argue that there is...
...rnia are finding out a new theory on the formation...hich connect other brain regions forming a new pro...eet of around 10 billion neurons divided into dist...haped by the environment? The protomap and protoco...
Other Medicine News:Health News:Meditation Maintains And Thickens The Grey Matter Of The Brain 2Health News:Bird Flu Likely To Reduce World Energy Demand 2Health News:Medical Breakthrough - Kidney Transplant Recipient Survives Without Drugs 2Health News:Another Benefit For Human Health Attributed To Omega-3-Fats 2Health News:Scientists breaking theory of cortex formation 2
Ultrafin™ Stirrup
6"H Plexiglass Armshield
Armboards
3D/SwingerOperating Table Clamp
Medicine Products: