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Amylin Pharmaceuticals Reports Third Quarter Financial Results
Date:10/20/2009

------ ------- ------ ------- Total costs and expenses 233,637 277,104 740,382 834,599 Operating loss (22,402) (58,742) (126,101) (196,981) Interest and other income, net (4,257) (5,338) (8,507) (4,789) Loss on impairment of investments - (14,943) (1,377) (14,943) ------ ------ ----- ------ Net loss $(26,659) $(79,023) $(135,985) $(216,713) ======== ======== ========= ========= Net loss per share - basic and diluted $(0.19) $(0.58) $(0.97) $(1.58) ====== ====== ====== ====== Shares used in computing net loss per share - basic and diluted 141,308 137,389 140,350 136,799

A reconciliation of reported GAAP operating loss to non-GAAP operating income (loss) excluding non-cash items and one-time items is provided in the table that follows (in thousands, unaudited):


                                       Quarter ended      Nine months ended
                                        September 30,        September 30,
                                       2009      2008      2009        2008
                                       ----      ----      ----        ----
    GAAP operating loss             $(22,402) $(58,742) $(126,101) $(196,981)

    Stock-based compensation          10,900    14,009     33,947     43,011
    Other non-cash compensation        4,392     5,531     15,719     18,847
    Depreciation and amortization      8,733     7,594     26,587     21,333
    Amortization of deferred revenue  (1,033)   (1,071)    (3,176)    (3,214)
    Restructuring                          -         -     11,376          -
                                       -----    ------     ------     ------

    Non-GAAP operating 
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SOURCE Amylin Pharmaceuticals, Inc.
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