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Ampio Pharmaceuticals subsidiary Luoxis Diagnostics announces positive summary data from study of traumatic brain injury patients and issuance of company's third US patent for its oxidation-reduction potential diagnostic platform
Date:10/1/2013

he 645 patients included in this study, 69% were <65 years old, 61% were males, and median brain Abbreviated Injury Score (AIS) was 3. There were 11 deaths and 56 patients were discharged to a skilled nursing facility. After adjustment in a multivariate logistic regression model, a 20mV increase in the first ORP measurement (obtained within 48 hours of admission) was associated with a 4-fold odds increase of in-hospital mortality (OR: 4.24, 95%CI: 1.2-15.3) and 1.3-fold odds increase of being discharged to a SNF (OR: 1.28, 95%CI: 1.00-1.63).  Likewise, decrease in antioxidant reserves, as measured by last inverse Capacity (1/cORP) were associated with significant patients outcomes. For example a 1 unit increase in the last inverse cORP was associated with a 5-fold odds increase in hospital mortality (OR: 5.05, 95%CI 1.2-21.3). Detailed results from this study will be presented at an upcoming scientific meeting. 

Luoxis' Chief Scientific Officer David Bar-Or, MD, commented "this recent analysis in traumatic brain injury demonstrates again how oxidation-reduction potential and antioxidant reserves serve as important markers of injury in this significant condition.  By having a novel measure like ORP available for rapid analysis of oxidative stress and antioxidant reserves, we can enable better clinical insights into these traumatic brain injury patients and potentially improve clinical management based on their condition's severity and ORP measures."

Traumatic brain injury affects at least 1.7 million patients in the US alone each year, and the incidence is highest among patients 75 years of age and older.  Luoxis Diagnostics is studying specific conditions where oxidative stress is implicated, and the company has a distinct focus on critical illness, injury, and frailty among the elderly population.  Additional studies are ongoing to assess oxidation-reduction potential in multiple conditions, and the RedoxSYS diagnostic sys
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SOURCE Luoxis Diagnostics; Ampio Pharmaceuticals, Inc.
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