Navigation Links
Ampio Pharmaceuticals Announces a Proof of Concept Trial of Danazol in the Treatment of Allergic Rhinitis Supports Mechanism of Action of Optina™
Date:10/18/2011

GREENWOOD VILLAGE, Colo., Oct. 18, 2011 /PRNewswire/ -- Ampio Pharmaceuticals, Inc. (NASDAQ: AMPE) ("Ampio" or the "Company"), a company that discovers and develops new uses for previously approved drugs and new molecular entities ("NMEs"), today announced that it has demonstrated in an IRB approved, randomized, placebo controlled, double-blinded proof of concept study, that low dose intranasal danazol has an impact on allergic rhinitis, a clinical condition in which increases in vascular permeability and edema are hallmark signs.

The study was not powered to show statistical significance as an effective treatment for rhinitis but rather intended to investigate the effect of danazol in a clinical condition associated with vascular permeability and edema.  After a 7 day washout period, patients were treated twice a day for 14 days with either placebo (n=10) or low-dose intranasal danazol (n=10) and assessed two times per day (AM and PM) using the validated Total Nasal Symptom Score (TNSS).  A larger decrease in TNSS indicates a greater improvement in symptoms.  A comparison of the PM score showed a strong trend toward efficacy, with a total mean change between washout and treatment of -2.39 for the treatment group compared to -0.34 for the placebo (p=0.10).  

"The pathogenesis of edema is very similar in different diseases.  The fact that low dose danazol could decrease edema in this setting is exciting, as it may indicate a similar impact of Optina™ on DME (Diabetic Macular Edema)," said Dr. Vaughan Clift, Chief Regulatory Officer of Ampio Pharmaceuticals, noting that "an oral formulation of low dose danazol (Optina™) is already the subject of a placebo-controlled, dose ranging trial in DME, the results of which are expected in Q2 2012."

About Optina(TM) (danazol)

Danazol is a weak androgen approved at high do
'/>"/>

SOURCE Ampio Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Ampio Pharmaceuticals Receives Notice of Allowance of its Two Patent Applications on the Combination of Zertane™ with Erectile Dysfunction Drugs in Canada
2. Ampio Announces Positive Results From 12-Week Open Label Extension Study of Zertane™ in Patients With Premature Ejaculation.
3. Champions Oncology Reports Fiscal 2012 First Quarter Financial Results
4. Ampio Pharmaceuticals Executes License and Development Agreement with Daewoong Co. Ltd. to Commercialize Zertane™ in South Korea
5. Ampio Pharmaceuticals Announces Treatment of First Patient in Phase 1b Ampion-In -Knee (AIK) Trial for Osteoarthritis in Australia
6. Ampio Pharmaceuticals, Inc. Releases Results From Phase III Clinical Trial of Zertane™ for the Treatment of Premature Ejaculation (PE), the Most Prevalent Form of Male Sexual Dysfunction
7. Ampio Pharmaceuticals Set to Join Russell 3000 Index
8. Ampio Pharmaceuticals, Inc. Appoints New Independent Director
9. Ampio Pharmaceuticals, Inc. to Begin Trading on the NASDAQ Capital Market
10. Ampio Pharmaceuticals, Inc. Receives Approval to List on the NASDAQ Capital Market
11. Five Californians Selected as Breakaway from Cancer® Champions to be Honored During Amgen Tour of California
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/26/2014)... -- CARsgen, a leader in the development of Chimeric Antigen ... of cancers, today announced the completion of a series ... -based healthcare private equity fund.   ... of new therapeutics for liver, lung, stomach and brain ... Renji Hospital, the company plans to initiate clinical studies ...
(Date:11/26/2014)... 26, 2014 The medical magnetic resonance ... of 4%, with world market revenues for 2013 ... and other types of medical imaging have led ... numerous medical conditions in children and adults, each ... report, Medical Imaging Markets , analyzes the ...
(Date:11/26/2014)... 25, 2014 According to ... Power Source (Electric, Battery, Pneumatic), by Product (Drill, ... Cart), by Application (Orthopedic, ENT, Oral, Thoracic, Neurology) ... global Powered Surgical Instruments Market is estimated to ... 2014 and is expected to grow at a ...
Breaking Medicine Technology:CARsgen Completes Series A Financing 2Kalorama: Steady Growth in the Medical MRI Market 2Kalorama: Steady Growth in the Medical MRI Market 3Powered Surgical Instruments Market Worth $2.1 Billion by 2019 2Powered Surgical Instruments Market Worth $2.1 Billion by 2019 3Powered Surgical Instruments Market Worth $2.1 Billion by 2019 4
... Data show comparable safety for complex patients treated ... Feb. 18 Boston Scientific Corporation (NYSE: ... results from its landmark SYNTAX(TM) trial in this ... Medicine. In the study, percutaneous coronary intervention ...
... in 2008, According to Millennium Research GroupWALTHAM, Mass., Feb. ... US Markets for Interventional Cardiology Devices 2009 report, ... steadily through 2013, driven in large part by the ... Myocardial Infarction (AMI) patients, who accounted for nearly 150,000 ...
Cached Medicine Technology:New England Journal of Medicine Publishes Results from Boston Scientific's Landmark SYNTAX(TM) Trial 2New England Journal of Medicine Publishes Results from Boston Scientific's Landmark SYNTAX(TM) Trial 3New England Journal of Medicine Publishes Results from Boston Scientific's Landmark SYNTAX(TM) Trial 4New England Journal of Medicine Publishes Results from Boston Scientific's Landmark SYNTAX(TM) Trial 5Adoption of PCI in AMI Patients to Drive Drug-Eluting Stent Use 2
(Date:11/27/2014)... In addition to a new dessert recipe ... this holiday season and become educated about the warning ... over the holidays may raise questions about the physical ... in cognitive ability can occur with age, serious memory ... the difference between normal aging and more serious problems ...
(Date:11/26/2014)... Angeles, CA (PRWEB) November 26, 2014 ... to treat themselves this holiday season! With Parsa Mohebi ... incredible 10% off of their next FUE procedure, making ... transplant. , FUE—which stands for “Follicular Unit Extraction”—is an ... advantages over traditional “strip” Follicular Unit Transplantation (FUT). FUE, ...
(Date:11/26/2014)... 2014 Boxing Day is traditionally the ... receive gifts, known as a "Christmas box", from their ... With the coming of Boxing Day, some people may ... before every business opportunity, and it has recently announced ... site-wide promotion for its global customers. Then people can ...
(Date:11/26/2014)... Dallas, Texas (PRWEB) November 26, 2014 ... surgeon and Distinguished Teaching Professor in the ... Center, recently discussed facial fat compartments, fat grafting, ... Surgery, The Meeting," an annual conference held by ... importance and intricacies of this underlying facial structure ...
(Date:11/26/2014)... HealthDay Reporter WEDNESDAY, Nov. 26, 2014 ... understand what they,re saying, a new study suggests they are ... way. Past research has shown that dogs respond to ... and the emotional tone, said study author Victoria Ratcliffe. ... canine brain, according to Ratcliffe, a Ph.D. candidate at the ...
Breaking Medicine News(10 mins):Health News:Alzheimer's Association Shares Tips to Navigate the Holiday Season 2Health News:Alzheimer's Association Shares Tips to Navigate the Holiday Season 3Health News:Alzheimer's Association Shares Tips to Navigate the Holiday Season 4Health News:Alzheimer's Association Shares Tips to Navigate the Holiday Season 5Health News:FUE Special at Parsa Mohebi Hair Restoration This Holiday Season 2Health News:Tbdress.com: Best Boxing Day Sales For Ladies Worldwide 2Health News:Dr. Rod J. Rohrich Discusses Facelifts at ASPS Annual Assembly 2Health News:Dr. Rod J. Rohrich Discusses Facelifts at ASPS Annual Assembly 3Health News:Your Dog Really Is Listening to You 2Health News:Your Dog Really Is Listening to You 3
... Springer will add the Journal of Cancer Education ... on behalf of the American Association for Cancer Education and ... a varied editorial board made up of MDs and PhDs ... worldwide. The Journal of Cancer Education presents ...
... ... leader in call tracking, performance analysis, sales and management training, announced that its non-profit ... loss in a Super Bowl Hearing Mission on Wednesday, February 3rd, from noon – ... ...
... NASHVILLE, Tenn. , Jan. 29 HCA ... quarter and fiscal year ended December 31, 2009 . ... Company,s year-end financial and accounting procedures. , (Logo: ... these uncertain economic times," said Richard M. Bracken , ...
... , DETROIT , Jan. 29 ... Ph.D., has been named the new president and chief executive ... oncologist, Dr. Bepler will begin his new position Feb. ... , In addition to his chief administrative duties, Dr. Bepler ...
... , CHICAGO , Jan. 29 ... national organizations representing dentists, physicians and veterinarians called on ... professionals from controversial new regulation intended to combat identity ... sent to FTC Chairman Jon Leibowitz by ...
... Research may advance development of facial recognition systems, study authors ... learn to recognize human faces, as long as they think ... In a series of experiments, researchers from Australia and France ... when they were rewarded with a sweet treat for doing ...
Cached Medicine News:Health News:CallSource joins Starkey Hearing Foundation to Tackle Children's Hearing Loss in Super Bowl Mission 2Health News:HCA Previews Fourth Quarter and Year-End 2009 Results 2Health News:HCA Previews Fourth Quarter and Year-End 2009 Results 3Health News:HCA Previews Fourth Quarter and Year-End 2009 Results 4Health News:HCA Previews Fourth Quarter and Year-End 2009 Results 5Health News:HCA Previews Fourth Quarter and Year-End 2009 Results 6Health News:HCA Previews Fourth Quarter and Year-End 2009 Results 7Health News:HCA Previews Fourth Quarter and Year-End 2009 Results 8Health News:Karmanos Cancer Institute in Detroit Names Gerold Bepler, M.D., Ph.D., as CEO 2Health News:Karmanos Cancer Institute in Detroit Names Gerold Bepler, M.D., Ph.D., as CEO 3Health News:Karmanos Cancer Institute in Detroit Names Gerold Bepler, M.D., Ph.D., as CEO 4Health News:Health Professionals Petition FTC For Relief From Red Flags Rule 2Health News:Health Professionals Petition FTC For Relief From Red Flags Rule 3
... Edition, gives the Physician, the Administrator and ... MD Coder Web Edition over the internet. ... features of the Enterprise Server but leaves ... maintenance, upgrades and white glove user support ...
Preferred Health Resourses Practice Management System is called Remedy. The PDA version is Remedy for the Palm. It is a data capture program for your medical billing....
... and Management guidelines in selecting billing codes. As ... calculates the HCFA scores for each area and ... of changing different parts of the exam. ZapCode ... to create an audit trail of your exam. ...
... Manager is an electronic database ... data management of wounds and ... developed using industry expert consultants ... the most current assessment and ...
Medicine Products: