Navigation Links
Ampio Pharmaceuticals, Inc. Announces Additional Positive Results for Ampion(TM) in Osteoarthritis of the Knee Clinical Trial
Date:9/30/2013

lgesics. In the pivotal trial of a single IA injection of 6 ml Hylan G-F 20, a borderline statistically significant reduction in pain was demonstrated, with an estimated difference from control of -0.15 (95% CI: -0.30 to -0.002, p = 0.047), corresponding to a 31.3% improvement in pain over 26 weeks in patients treated with Hylan G-F20.

Note: The accepted threshold for a Minimum Clinically Important Improvement (MCII), defined as the smallest change in a measurement that signifies important improvement in a patient's symptom, is -40.8% [Ann Rheum Dis. 2005;64:29-33 Tubach F, Ravaud P, Baron G, et al. Evaluation of clinically relevant changes in patient reported outcomes in knee and hip osteoarthritis: the minimal clinically important improvement] in WOMAC A pain change from baseline with knee OA, which only Ampion exceeded as an intra-articular injection.

  • The Ampion SPRING study included "all comers", including Kellgren-Lawrence IV patients that make up a significant portion of the "real world" osteoarthritis patients (19% in the SPRING study). Ampion was not only effective overall (p=0.004) as previously reported, but was specifically effective in the subset of patients with severe osteoarthritis (Kellgren-Lawrence IV, p=0.017) who currently face a severe unmet medical need.

Note: In contrast pivotal trials for the approved hyaluronic acid and derivatives, which commonly exclude patients with severe osteoarthritis (Kellgren-Lawrence IV stage of disease), these patients are sometimes considered "intractable" due to lack of efficacy of any approved therapy (NSAIDS, hyaluronic acid and steroids). The only accepted therapy is joint replacement, which is not only a significant patient burden but also has significant morbidity associated with it and is contraindicated in many patients with comorbidities.

'/>"/>
SOURCE Ampio Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Ampio Pharmaceuticals, Inc. Announces $25 Million Financing
2. Astellas to Host Executive Womens Day at 2013 TOUR Championship by Coca-Cola
3. Ampio Pharmaceuticals, Inc. Announces Positive Results for Ampion in Osteoarthritis of the Knee Clinical Trial
4. Levine Leichtman Acquires Champion Manufacturing
5. Pro Athletes Team Up to Champion Gout Awareness
6. Dr. Helen Fisher to Speak at Astellas Presents Executive Womens Day at the Constellation SENIOR PLAYERS Championship
7. Ampio Pharmaceuticals Issues Statement Regarding Misleading Blog
8. Ampio Pharmaceuticals to List on the NYSE MKT
9. Ampio Pharmaceuticals Provides Clinical Updates
10. Synergy Health Wins Practice Green Health Champion for Change Award
11. Ampio Pharmaceuticals Completes Enrollment in Run-In SPRING study of Ampion in Osteoarthritis of the Knee
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... Pa. , June 30, 2015 Zynerba Pharmaceuticals, ... on Form S-1 with the U.S. Securities and Exchange Commission ... common stock. The number of shares to be offered and ... determined. Jefferies LLC and Piper Jaffray ... offering, and Canaccord Genuity Inc. and Oppenheimer & Co. Inc. ...
(Date:6/30/2015)... , June 30, 2015 Dipexium Pharmaceuticals, ... pharmaceutical company focused on the development and commercialization ... closing of its previously announced underwritten public offering ... also exercised their over-allotment option in full to ... The net proceeds to Dipexium are ...
(Date:6/30/2015)... VALLEY, Pa. , June 30, 2015 /PRNewswire/ ... and delivering innovative solutions for medical and surgical ... is guaranteeing next-day replacements for surgical equipment at ... product manufacturer to offer this type of guarantee. ... Olympus Full Service Agreement earlier this year. ...
Breaking Medicine Technology:Zynerba Files Registration Statement for Proposed Initial Public Offering of Common Stock 2Dipexium Announces Closing of Public Offering of Common Stock 2Dipexium Announces Closing of Public Offering of Common Stock 3Olympus Introduces Industry-First Next-Day Product Replacement Guarantee for Surgical Business 2Olympus Introduces Industry-First Next-Day Product Replacement Guarantee for Surgical Business 3
(Date:7/1/2015)... ... July 01, 2015 , ... The executive ... and marketing of a number of nutritional and beauty products, announced the company ... ECRM Diet, Vitamin & Sports Nutrition conference in Tampa, Florida. This specific ECRM ...
(Date:7/1/2015)... ... 01, 2015 , ... Nutritional Products International, a brand focused on the global ... the 2015 ECRM Diet, Vitamin & Sports Nutrition conference in Tampa, Florida, where it ... ECRM trade show allows companies the chance to meet with a variety of the ...
(Date:7/1/2015)... NV (PRWEB) , ... July 01, 2015 , ... ... be showcasing the newly launched Patient Self-Management (PSM) Solutions at the Society for ... that has been in use for over 10 years, can reduce overall cost ...
(Date:6/30/2015)... ... 01, 2015 , ... Avid boxing style rock concert poster collector, Andrew Hawley ... posters. The Who and the Rascals also played at this concert in New York ... played with the Who backing them up. The Doors gave a very stirring performance ...
(Date:6/30/2015)... ... July 01, 2015 , ... ... responsive and easy to navigate. By making fundamental changes to the UI, the ... from the site said, “Finding the right website has been getting tougher. People ...
Breaking Medicine News(10 mins):Health News:NPI Executives Report Great Success at ECRM Conference 2Health News:NPI Meets With Top Retail Figures at ECRM Conference 2Health News:APhA Foundation to Showcase Newly Introduced Patient Self-Management Solutions at the Society for Human Resource Management (SHRM) Annual Conference and Exposition 2Health News:Avid Boxing Style Rock Concert Poster Collector From Vintage Rock Posters Announces Search for 1968 Doors and Jimi Hendrix Singer Bowl Concert Posters 2Health News:HerpesDatingSites.org Introduces a New Responsive Design 2
... MONDAY, Nov. 15 (HealthDay News) -- People who wear multifocal ... who wear glasses, a new study finds. Multifocal lenses ... common with age. This study included 11 volunteers, aged ... track at night. Wearing multifocal contact lenses resulted ...
... on gaming and health in adolescents, conducted by researchers ... differences linked to gaming as well as important health ... journal Pediatrics , the study is among the ... gaming and problematic gaming in a community sample of ...
... is approximately 40 percent and show no sign of ... to tackle the problem using a comprehensive and pioneering ... partnerships with the Cleveland Metropolitan School District (CMSD) and ... National Institutes of Health (NIH)-funded program will be led ...
... world,s first remote heart procedure, using a robotic arm alongside ... in Leicester. It comes six months after Dr ... procedure using the Amigo Robotic Catheter System. Dr ... consultant cardiologist and electrophysiologist at Glenfield Hospital. On ...
... , MONDAY, Nov. 15 (HealthDay News) -- Although automated external ... in public places such as restaurants, malls and airplanes, they ... of death when used in hospitals, a new study suggests. ... of heart rhythms associated with the heart attack, said researchers ...
... with the cardiac diagnostic imaging technique of myocardial perfusion imaging ... high cumulative estimated radiation dose, according to a study in ... is being released early online because it is being presented ... medical imaging has grown rapidly in recent years, but along ...
Cached Medicine News:Health News:When video games get problematic so do smoking, drug use and aggression 2Health News:Community rallies to fight obesity in Cleveland's urban youth 2Health News:Community rallies to fight obesity in Cleveland's urban youth 3Health News:Community rallies to fight obesity in Cleveland's urban youth 4Health News:Robo-op marks new world first for heart procedure 2Health News:External Defibrillators Not Much Help in Hospitals 2Health News:External Defibrillators Not Much Help in Hospitals 3Health News:Common for patients to undergo multiple cardiac imaging tests, with high cumulative radiation dose 2Health News:Common for patients to undergo multiple cardiac imaging tests, with high cumulative radiation dose 3
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: