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Amorcyte Stem Cell Therapy Demonstrates Clinically Significant Reperfusion in Severe Heart Attack Patients
Date:12/21/2010

nificant improvement in resting perfusion rates at six months as compared to patients receiving 5 million cells (n=6) and control (n=15), as measured by the SPECT total severity score, (-256 versus +13, p=0.01).  Furthermore, patients receiving 10 or more million cells showed a trend towards improvement in ejection fraction, the percentage of blood pumped out of a ventricle with each heartbeat, (+4% versus +1%); end systolic volume (-5.7mL versus -0.1mL); and infarct size, tissue death due to loss of adequate blood supply, (-10% versus -3%) at six month follow-up. 

"AMR-001 showed the potential for a patient's own stem cells to reduce serious long-term complications from a heart attack," said Arshed Quyyumi, M.D., FRCP, FACC, Professor of Medicine, Division of Cardiology, at Emory University School of Medicine and the trial's principal investigator and co-author of the report.  "This novel therapy may help severe heart attack patients, who are at the most risk for further downstream events.  I look forward to further investigation of AMR-001 and its potential benefits in the care of heart attack patients."  

Of the 1 million heart attacks in the U.S. each year, nearly 20 percent are severe enough to cause ventricular remodeling. Amorcyte's patented technologies and cGMP (current good manufacturing practices) manufacturing processes address the therapeutic and commercial challenges to post-MI stem cell treatment. Unlike other approaches, Amorcyte's technology has established stem cell product potency, purity, sterility and dose, along with product shelf-life. 

"This publication further demonstrates the potential importance AMR-001 may have on the treatment of heart attack patients," said Andrew Pecora, M.D., Amorcyte Founder and Chief Science Officer  "AMR-001 is the first stem cell therapy to demonstrate neoangiogenesis (formation of new blood vessels) in a threshold dose, in heart muscle damaged from a seve
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SOURCE Amorcyte, Inc.
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