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Amorcyte Stem Cell Therapy Demonstrates Clinically Significant Reperfusion in Severe Heart Attack Patients
Date:12/21/2010

ALLENDALE, N.J., Dec. 21, 2010 /PRNewswire/ -- The American Heart Journal today reported results of a clinical trial evaluating Amorcyte, Inc.'s lead product candidate, AMR-001 for the treatment of damaged heart muscle following acute myocardial infarction (AMI).  Data demonstrated a significant relationship between cell dose and biologic effect. This is the first and only study to prospectively define a dose of a purified and potent autologous (self-donating) stem cell therapy that resulted in a significant improvement in perfusion, a trend towards improved cardiac function and the potential to reduce subsequent adverse cardiac events following AMI.

The report was authored by researchers from Emory University, Northwestern University, Texas Heart Institute, The Christ Hospital Heart and Vascular Center in Cincinnati, Ohio, Mayo Clinic College of Medicine, Amorcyte, Inc. and Progenitor Cell Therapy, LLC.

The 31 patients in the Phase I trial were randomly assigned to an autologous stem cell harvest group (cells were harvested from the patient's own bone marrow) or control group five days after an ST elevation myocardial infarction (STEMI) characterized by a prolonged period of hypoperfusion (blocked blood supply).  CD34+ cells having CXCR-4+ receptors were then isolated from the bone marrow, and enriched to increase potency using Amorcyte's patented technology into five, 10 and 15 million cell doses.  The cells were infused into the patient via the infarct-related artery seven to 11 days following the STEMI – the optimal time frame to attempt to prevent adverse ventricular remodeling.  Caused by the progressive decline in heart muscle function following an AMI, ventricular remodeling can lead to permanent heart damage and increase the risk of recurrent heart attack, other adverse cardiac events and death. 

The study results demonstrated that patients receiving 10 to 15 million cells (n=9) experienced sig
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SOURCE Amorcyte, Inc.
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