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Among New Agents Entering the Unipolar Depression Market Over the Next Decade, Lundbeck/Takeda Pharmaceutical's Brintellix Has Blockbuster Potential
Date:8/1/2013

8212;Eli Lilly's edivoxetine and Forest Laboratories/Pierre Fabre's Fetzima—will be insufficient to counteract this decline; edivoxetine and Fetzima will together reach just under $1 billion in sales across the major markets by 2022.

Furthermore, the atypical antipsychotic drug class will experience significant loss of sales in the unipolar depression market owing to continued generic erosion of key agents and, including generic competition to Abilify. Consequently, major-market sales of this drug class will drop by half, to just under $1 billion in 2022. The forecasted launch of Otsuka/Lundbeck's brexpiprazole and the expanded use of Dainippon Sumitomo Pharma/Sunovion/Takeda's Latuda across the major markets will only partially offset the forthcoming decline in drug class sales.

"In a highly genericized and fragmented market, in which SSRIs and serotonin and norepinephrine reuptake inhibitors (SNRIs) are and will remain deeply entrenched first-line agents, the uptake of emerging therapies among physicians will be highly dependent on their successful differentiation from currently available SSRIs and SNRIs," said Decision Resources Senior Business Insights Analyst Alana K. Simorellis, Ph.D. "An agent benefitting patients who fail to respond to current treatments or one that treats residual symptoms of depression represent opportunities for drug developers. An antidepressant or antipsychotic proven to be more effective in treatment-resistant patients would quickly gain physician acceptance and experience use, likely as part of an augmentation strategy."

*Unipolar depression encompasses major depressive disorder, minor depression and dysthymia.

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