Navigation Links
Amira Pharmaceuticals Announces Efficacy of LPA1 Antagonist in a Preclinical Model of Scleroderma
Date:2/10/2010

SAN DIEGO, Feb. 10 /PRNewswire/ -- Amira Pharmaceuticals, Inc. announced today that their collaborators, Andrew Tager, M.D. and Flavia V. Castelino, M.D. of Massachusetts General Hospital, Harvard Medical School, will present a preclinical proof-of-concept study which demonstrates that the bioactive lipid lysophosphatidic acid (LPA), through its high affinity LPA1 receptor, is an important mediator of fibrogenesis in the bleomycin mouse model of scleroderma.  Data will be presented as part of a poster session for the 1st Systemic Sclerosis World Congress to be held in Florence, Italy, February 11 to 13, 2010.

"Our data shows that in mice deficient for the LPA1 receptor, there is dramatic protection from the bleomycin-induced skin fibrosis seen in normal mice," said Dr. Tager, a member of Amira's Scientific Advisory Board.  "In addition, similar protection from fibrosis was observed in normal mice treated with Amira's LPA1 receptor antagonist, AM095."

Peppi Prasit, Ph.D., Chief Scientific Officer, said, "AM095 is an orally available, potent and selective antagonist of the LPA1 receptor.  We are currently moving AM095 and AM152, another LPA1 antagonist, through GLP toxicology testing and expect to initiate human clinical studies in the second half of 2010."

Bob Baltera, Chief Executive Officer, added, "So far we have seen compelling data in numerous preclinical models of fibrosis.  We are excited by the possibility of eventually exploring efficacy in human disease settings, such as idiopathic pulmonary fibrosis, scleroderma, kidney and liver fibrosis, and various metastatic cancers. There is a lot of work to be done
'/>"/>

SOURCE Amira Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. Amira Pharmaceuticals Announces Initial Positive Phase 1 Clinical Data for AM461, A Back-Up to Amiras Lead DP2 Antagonist, AM211
2. Amira Pharmaceuticals Submits IND for Second DP2 Antagonist, AM461
3. ISTA Pharmaceuticals Announces 2010 Financial Guidance
4. Savient Pharmaceuticals To Hold Fourth Quarter And Year-End 2009 Results Conference Call On Friday, February 26, 2010
5. Sagent Pharmaceuticals Announces FDA Approval of Labetalol Hydrochloride Injection, USP
6. Anthera Pharmaceuticals Announces Agreement With the FDA on a SPA for Planned Phase 3 Varespladib A-002 Study; Daniel K. Spiegelman Joins Board of Directors
7. Novavax Terminates Negotiations with ROVI Pharmaceuticals for Influenza Vaccine Collaboration
8. Strativa Pharmaceuticals Provides An Update On Zuplenz(R) (Ondansetron) Oral Soluble Film
9. Poniard Pharmaceuticals to Present at 12th Annual BIO CEO and Investor Conference
10. Infosys Technologies and Elan Pharmaceuticals Apply Co-creation Model to Transform Discovery Research
11. Lexicon Pharmaceuticals to Present at the 12th Annual BIO CEO & Investor Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... FRANCISCO , July 28, 2014  Dignity ... it has received the Get With The Guidelines®-Stroke ... improvement measures outlined by the American Heart Association/American ... Stroke is the number four cause of death ... the United States , according ...
(Date:7/28/2014)... Calif. , July 28, 2014 STAAR ... developer, manufacturer and marketer of implantable lenses and delivery ... its second quarter results and conference call with investors ... July 30, 2014.  The Company rescheduled the release date ... the funeral services for Hideo Watanabe , President ...
(Date:7/28/2014)... July 28, 2014  MiMedx Group, Inc. (NASDAQ: MDXG ... regenerative biomaterials and bioimplants processed from human amniotic membrane, announced ... Highlights include: , Revenue exceeds ... 2013 to $25.6 million , Quarter-over-quarter ... Care revenue increases 181% over Q2 2013 and 40% sequentially ...
Breaking Medicine Technology:Dignity Health St. Mary's Medical Center Honored with Quality Achievement Award for Stroke Care 2Dignity Health St. Mary's Medical Center Honored with Quality Achievement Award for Stroke Care 3STAAR Surgical Moves Second Quarter Earnings Release and Conference Call One Day to July 31 2MiMedx Announces Record Second Quarter Results 2MiMedx Announces Record Second Quarter Results 3MiMedx Announces Record Second Quarter Results 4MiMedx Announces Record Second Quarter Results 5MiMedx Announces Record Second Quarter Results 6MiMedx Announces Record Second Quarter Results 7MiMedx Announces Record Second Quarter Results 8MiMedx Announces Record Second Quarter Results 9MiMedx Announces Record Second Quarter Results 10MiMedx Announces Record Second Quarter Results 11MiMedx Announces Record Second Quarter Results 12MiMedx Announces Record Second Quarter Results 13MiMedx Announces Record Second Quarter Results 14MiMedx Announces Record Second Quarter Results 15MiMedx Announces Record Second Quarter Results 16MiMedx Announces Record Second Quarter Results 17MiMedx Announces Record Second Quarter Results 18
(Date:7/29/2014)... Premier Women’s Health , a six-physician ... has affiliated with Allegheny Health Network’s renowned Women’s Health ... babies and perform surgical procedures at Heritage Valley Sewickley. ... referred to Allegheny Health Network’s West Penn Hospital ... West Penn Hospital and its highly regarded Women’s Health ...
(Date:7/29/2014)... IsoComforter, Inc ., one of ... today the introduction of the innovative new Iso-Hip Wrap. ... created for post operative hip replacement patients. The plush ... the benefits of cold therapy while resting, sitting, or ... replacements are done every year. Cold therapy is ...
(Date:7/29/2014)... According to the new market research report, ... Material (Optical Prism, Pizeoelectric, Capacitive, and Adhesives), Application ... Banking & Finance), and Geography - Global Trends ... MarketsandMarkets, the global Fingerprint Sensors Market is projected ... a high CAGR of 16.8% from 2014 to ...
(Date:7/29/2014)... 29, 2014 Test instruments after ... and protein soils where it matters most – ... leading manufacturer of premium domestic appliances, introduces ProCare ... instruments are effectively cleaned. The ProCare liquid is ... immediately after processing. After 3 minutes, users visually ...
(Date:7/29/2014)... (CA) method is in principle suitable to find out ... widely use it in health economic evaluations, some (primarily ... the result of a pilot project by the German ... Following the Analytic Hierarchy Process (AHP), CA is the ... experts. , Summarize outcome-specific results to an overall ...
Breaking Medicine News(10 mins):Health News:Leading West Suburban OBGYN Practice, Premier Women’s Health, Joins Allegheny Health Network 2Health News:Leading West Suburban OBGYN Practice, Premier Women’s Health, Joins Allegheny Health Network 3Health News:New IsoComforter Cold Therapy Unit Plus Hip Wrap Gives Post Operative Hip Replacement Patients Faster Recovery Times 2Health News:Fingerprint Sensors Market by Type (Swipe And Area) Estimated to Reach $14.35 Billion by 2020 - New Report by MarketsandMarkets 2Health News:Fingerprint Sensors Market by Type (Swipe And Area) Estimated to Reach $14.35 Billion by 2020 - New Report by MarketsandMarkets 3Health News:Fingerprint Sensors Market by Type (Swipe And Area) Estimated to Reach $14.35 Billion by 2020 - New Report by MarketsandMarkets 4Health News:ProCare Protein Check Tests Surgical Instruments to Verify Effective Cleaning 2Health News:Determine patient preferences by means of conjoint analysis 2Health News:Determine patient preferences by means of conjoint analysis 3Health News:Determine patient preferences by means of conjoint analysis 4
... Unhappy marriages are harmful to the self-esteem and health of ... to higher levels of psychological distress when compared to those ... as many as 1,150 people in unhappy // marriages ... of sociology, human development and family studies, and demography said ...
... the heart with the progress of age can be postponed by ... which the Journal of the American College of Cardiology has published. ... primary aging can // be delayed by restricting calories in human ... fact has already been proved in the case of small mammals. ...
... regard to the hormone replacement therapy (HRT), another research has put ... to the heart. //The risk of a coronary heart disease is ... the HRT at an younger age, when in comparison to women ... cardiovascular benefits to be seen in the case of women who ...
... Stetson have reported in the Journal Immunity that the host ... infection. // ,Viruses are classified based on their ... found that immune response which acts in recognisation of these ... RNA viruses. ,Immune response against the virus acts ...
... Professor Harvey Lodish and his post-doc Chengcheng Zhang from Whitehead ... of growth factors// which enriches and increases the number of ... into the recipient. ,Stem cell therapy as ... therapy is very high and it requires isolating large number ...
... Neurone Disease (MND), a fatal nerve disease could be improved ... ,Patients suffering from Motor Neurone Disease (MND) could ... works by helping people with MND who suffer from weakness ... reported. ,At present just one drug is licensed ...
Cached Medicine News:
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: