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Amicus Therapeutics Awarded $500,000 Grant from The Michael J. Fox Foundation for Development of Next-Generation Pharmacological Chaperone to Treat Parkinson's Disease
Date:12/8/2010

ty of brain GCase, prevented accumulation of α-synuclein in the brain, and improved motor function as assessed in various behavioral tests.  Through a significant medicinal chemistry effort, Amicus has identified new pharmacological chaperones that improve significantly on the properties of AT2101 and that have better potential for clinical development. 

About Parkinson's Disease

Parkinson's disease is a progressive neurological disease that affects over 1 million people in the US.  It is most commonly associated with changes in motor function such as tremor, rigidity, slowness of movement, and postural instability, but also affects cognition and peripheral functions.  The prevalence of Parkinson's increases above 60 years of age and thus the patient population is expected to grow in the next several decades.

About the Michael J. Fox Foundation for Parkinson's Research

Founded in 2000, MJFF is dedicated to finding a cure for Parkinson's disease through an aggressively funded research agenda and to ensuring the development of improved therapies for those living with Parkinson's today. The Foundation has funded more than $221 million in research to date. For more information, please visit www.michaeljfox.org.

About Amicus Therapeutics

Amicus Therapeutics is developing orally administered, small molecule drugs called pharmacological chaperones, a novel, first-in-class approach to treating a broad range of diseases including lysosomal storage disorders and neurodegenerative diseases.  Amicus' lead program is in Phase 3 for Fabry disease. For more information about Amicus please visit www.amicustherapeutics.com.

Forward-Looking Statements

This press release contains, and the accompanying conference call will contain, "forward-looking state
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