Navigation Links
Amicus Therapeutics Awarded $500,000 Grant from The Michael J. Fox Foundation for Development of Next-Generation Pharmacological Chaperone to Treat Parkinson's Disease
Date:12/8/2010

eir exciting pharmacological chaperone approach to modify the progression of Parkinson's disease," said Dr. Chesselet. "Amicus' earlier compound partially reversed the motor deficits in our alpha-synuclein overexpression mouse model, and we are eager to test the improved compounds."

John F. Crowley, Chairman and CEO of Amicus Therapeutics stated, "We appreciate MJFF's backing of our pharmacological chaperone technology and believe this grant further demonstrates the strong scientific capabilities at Amicus.  We hope that these continued discoveries will translate into therapies for people living with Parkinson's disease."

About Pharmacological Chaperones

Pharmacological chaperones are orally-available small molecules that selectively bind and stabilize target proteins to facilitate proper folding, reduce premature degradation, and increase the efficiency of protein trafficking through the cell.  The use of pharmacological chaperones may be broadly applicable to diseases where an increase in the activity of a specific protein may provide therapeutic benefit.  

About Pharmacological Chaperones for Parkinson's Disease

Mutations in the GBA1 gene are the most common genetic risk factor known for Parkinson's disease.  Those at increased risk include individuals who inherit only one mutant copy of GBA1, while the other copy is normal.  GBA1 mutations reduce the activity of the lysosomal enzyme glucocerebrosidase (GCase), which leads to Gaucher disease when two mutant copies of the gene are inherited.  Increasing the activity of GCase in the brain with a small-molecule pharmacological chaperone may reduce the negative consequences of carrying GBA1 mutations.  Amicus and collaborators have previously  demonstrated that administration of the pharmacological chaperone AT2101 to mice that were genetically engineered to over-produce -synuclein increased the activi
'/>"/>

SOURCE Amicus Therapeutics
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Amicus Therapeutics Announces Third Quarter 2010 Financial Results
2. GSK and Amicus Therapeutics Enter Exclusive Worldwide Agreement to Develop and Commercialize Amigal™ for Fabry Disease
3. Amicus Therapeutics to Host Conference Call and Webcast to Discuss Exclusive Worldwide Agreement with GSK to Develop and Commercialize Amigal™ for Fabry Disease
4. Amicus Therapeutics to Host Its Second Quarter 2010 Financial Results Conference Call and Webcast on August 5, 2010
5. Amicus CEO Represents BIO on Rare Diseases at U.S. Senate Committee on Health, Education, Labor and Pensions Bipartisan Hearing
6. Alzheimers Drug Discovery Foundation Funds Amicus Therapeutics To Advance Pharmacological Chaperone Technology
7. Fenwal Receives FDA Clearance for Amicus(R) Separator With Wireless Connectivity
8. Amicus Therapeutics to Host its First Quarter 2010 Financial Results Conference Call and Webcast on May 6, 2010
9. FDA Clears the Fenwal Amicus(R) Separator System for Collecting Platelets in New Additive Solution
10. Amicus Therapeutics Announces Closing of $18.5 Million Registered Direct Offering of Common Stock
11. Amicus Therapeutics Announces $18.5 Million Registered Direct Offering of Common Stock
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... , June 30, 2015  Ardelyx, Inc. (NASDAQ: ... gastrointestinal and metabolic diseases, today announced that the Company ... 2015, from 8:00 a.m.- 1:00 pm EDT in ... The Ardelyx senior management team will present an overview ... tenapanor, which has completed Phase 2b clinical trials for ...
(Date:6/30/2015)... Fla. , June 30, 2015  July 4 th ... declaration of independence, and the spirit and people behind it. ... Foundation has partnered with USA Medical ... help increase funding for programs that empower independence for our ... country, and help more people afford their prescriptions. ...
(Date:6/30/2015)... , June 30, 2015  Egalet Corporation ... integrated specialty pharmaceutical company focused on developing, ... announced top-line results from a Category 3 ... an abuse-deterrent, extended-release, oral oxycodone product candidate ... of pain severe enough to require daily, ...
Breaking Medicine Technology:Ardelyx to Host Inaugural R&D Investor Day in New York City on July 14, 2015 2Hope For Heroes and USA Medical Card Make a Difference for Our Nation's Heroes 2Egalet Announces Top-Line Results from Oral Human Abuse Liability Study of Egalet-002 2Egalet Announces Top-Line Results from Oral Human Abuse Liability Study of Egalet-002 3Egalet Announces Top-Line Results from Oral Human Abuse Liability Study of Egalet-002 4Egalet Announces Top-Line Results from Oral Human Abuse Liability Study of Egalet-002 5
... NEW CENTERS AND TO ... INCREASE AWARENESS AMONG CARDIOLOGISTS, PLEASANTON, Calif., April 21 ... mechanical,circulatory support therapies to save, support and restore failing hearts,said ... (PreMarket,Approval) application, allowing the use of its HeartMate II LVAS ...
... April 21 A new study funded by,Health ... correlation,between dietary consumption of the omega-3 DHA* and ... Universite Laval,researchers and published in the Journal of ... pregnancy boosts an infant,s sensory,cognitive, and motor development., ...
Cached Medicine Technology:Thoratec Announces FDA Approval of HeartMate II(R) for Bridge-To-Transplantation 2Thoratec Announces FDA Approval of HeartMate II(R) for Bridge-To-Transplantation 3Thoratec Announces FDA Approval of HeartMate II(R) for Bridge-To-Transplantation 4Thoratec Announces FDA Approval of HeartMate II(R) for Bridge-To-Transplantation 5Pregnant Women Need Omega-3 to Boost Infant Development 2
(Date:6/30/2015)... CA (PRWEB) , ... June 30, 2015 , ... ... Medicare rating in a new video, “Grand Terrace Health Care Center.” Each year, ... accountable and help patients find the best facility for their needs. Grand Terrace ...
(Date:6/30/2015)... ... June 30, 2015 , ... According to a June 15th ... grant to study how sensory stimuli can be used to “decrease children’s anxiety and ... for children with autism, will compare patient experience in a “typical dental environment” with ...
(Date:6/30/2015)... ... , ... Family and professional dementia caregivers are invited to ... 2015 at the Hyatt Regency Denver Tech Center from 7:30 am-4:30 pm. The ... the wife and daughter of singer Glen Campbell, who will discuss their experiences ...
(Date:6/30/2015)... (PRWEB) , ... June 30, 2015 , ... ... community. , Eleven physicians from Allied’s Fullerton division volunteered to help provide free ... Super Surgery Saturday, March 21, at St. Jude Medical Center. , The ...
(Date:6/30/2015)... ... June 30, 2015 , ... America’s oldest cancer center and ... cancer prevention, screening and care for the people of Nigeria. Roswell Park Cancer ... see Roswell Park faculty providing clinical consultations to assist LCC oncologists, who will ...
Breaking Medicine News(10 mins):Health News:Grand Terrace Health Care Center Announces Five-Star Rating in YouTube Video 2Health News:New Study Aims to Determine if Sensory Stimuli can Ease Dental Anxiety in Children, Notes Medical Center Dental Care 2Health News:New Study Aims to Determine if Sensory Stimuli can Ease Dental Anxiety in Children, Notes Medical Center Dental Care 3Health News:Family of Singer Glen Campbell to Discuss Living with Dementia at the Alzheimer's Association of Colorado's 26th Annual Education Symposium 2Health News:Allied Anesthesia Physicians Volunteer to Help Orange County’s Uninsured During Annual Super Surgery Saturday 2Health News:Allied Anesthesia Physicians Volunteer to Help Orange County’s Uninsured During Annual Super Surgery Saturday 3Health News:Intercontinental Oncology Partnership Brings Access to Specialized Cancer Care to Nigeria 2Health News:Intercontinental Oncology Partnership Brings Access to Specialized Cancer Care to Nigeria 3Health News:Intercontinental Oncology Partnership Brings Access to Specialized Cancer Care to Nigeria 4Health News:Intercontinental Oncology Partnership Brings Access to Specialized Cancer Care to Nigeria 5
... Smash Hit Show Features the bodybugg(TM) System-, SAN ... of NBC,s wildly popular unscripted reality series The Biggest ... win the $250,000 grand,prize, courtesy of 24 Hour Fitness. ... bodybugg, an intelligent calorie management system,designed to provide consumers ...
... Location for Columbia-Based Company, ANDERSON, S.C., Sept. 17 ... its seventh healthcare center in the,Upstate, located at 2126 ... 3, 2007. Dr. Stephen Parks, the Upstate Regional ... center is designed to provide,convenient urgent care, family care, ...
... Sept. 17 Today in Des Moines,Iowa, Democratic ... universal health care plan. A spokesperson for the,Employment ... "Any plan that tries to achieve universal ... is bound to fail," said Jill Jenkins, chief,economist ...
... as customer, regulatory pressures mount , , MONDAY, Sept. 17 ... order of fruit instead of fries with that cheeseburger. ... watching what you eat seems to be hitting more ... approach the counter of their favorite "quick-service" outlet, experts ...
... Oral Session and 21 Poster Sessions ... New Clostridium difficile Program , LOUISVILLE, Colo., Sept. ... that it will be presenting 21 posters,highlighting three major ... Agents and Chemotherapy (ICAAC) held at the,McCormick Place conference ...
... Sept. 17 If you get headaches, allergic,reactions or breathing ... cabin air filter. Cabin air filters clean the incoming air ... miles, or,per the owner,s manual, according to the Car Care ... import vehicles sold in the,U.S. today come equipped with cabin ...
Cached Medicine News:Health News:24 Hour Fitness Gives The Biggest Loser High-Tech Upgrade 2Health News:24 Hour Fitness Gives The Biggest Loser High-Tech Upgrade 3Health News:UCI Medical Affiliates Inc. Opens a New Doctors Care Center in Anderson 2Health News:The Nutrition-Conscious Take a Bite Out of Fast Food 2Health News:The Nutrition-Conscious Take a Bite Out of Fast Food 3Health News:The Nutrition-Conscious Take a Bite Out of Fast Food 4Health News:Replidyne Pipeline Featured at 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy 2Health News:Replidyne Pipeline Featured at 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy 3Health News:Replidyne Pipeline Featured at 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy 4Health News:Replidyne Pipeline Featured at 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy 5Health News:It's Probably Time to Replace Your Vehicle's Cabin Air Filter 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: