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Amicus Therapeutics Awarded $500,000 Grant from The Michael J. Fox Foundation for Development of Next-Generation Pharmacological Chaperone to Treat Parkinson's Disease
Date:12/8/2010

CRANBURY, N.J., Dec. 8, 2010 /PRNewswire/ -- Amicus Therapeutics (Nasdaq: FOLD), a biopharmaceutical company focused on developing treatments for rare diseases, today announced that it has been awarded a second grant from The Michael J. Fox Foundation for Parkinson's Research (MJFF) for the development of a novel, next-generation pharmacological chaperone for the treatment of Parkinson's disease.  The $500,000 award will be distributed over a period of 24 months. Amicus' studies will be conducted in collaboration with Marie-Francoise Chesselet, M.D., Ph.D. the Charles H. Markham Professor of Neurology and Chair, Department of Neurobiology, David Geffen School of Medicine at UCLA.  

"We are honored to receive this grant from the MJFF, which will help us further develop our novel treatment for Parkinson's disease," said David J. Lockhart, Ph.D., Amicus Therapeutics' Chief Scientific Officer.  "Currently available treatments for Parkinson's provide symptomatic relief only. Our therapy is designed to address a deficiency that is inherited in a subset of the Parkinson's population, and to actually modify the course of the disease.  The targeted compounds that we have discovered have shown promising effects in initial animal studies, and we are delighted to be working together with the MJFF and Dr. Chesselet to advance our lead compound into advanced preclinical studies."

The studies will focus on the Parkinson's-implicated protein alpha-synuclein. Accumulation of alpha-synuclein in the nervous system is a hallmark of Parkinson's disease. Amicus is working on a strategy to reduce levels of synuclein in the brain, in the hope that this would lessen the changes in the brain seen in Parkinson's disease -- such as loss of the neurotransmitter dopamine -- and resulting behavioral changes.    

"I am pleased to continue working with Amicus on th
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