Amicus Therapeutics Announces Second Quarter 2008 Financi...(re-tax charges for changes in the fair v...),Health

Use of Non-GAAP Financial Measures

Amicus' "non-GAAP net loss" and "non-GAAP diluted net loss per common share" financial measures are defined as reported, or GAAP, net loss and diluted net loss per common share excluding certain items further discussed below. Amicus' management uses these non-GAAP financial measures to establish financial goals and to gain an understanding of the comparative financial performance of Amicus from year to year and quarter to quarter. Accordingly, Amicus believes investors' understanding of Amicus' financial performance is enhanced as a result of disclosing these non-GAAP financial measures. Non-GAAP net loss and diluted net loss per common share should not be viewed in isolation or as a substitute for reported, or GAAP net loss and diluted net loss per common share.

(1) Stock option expense -- Non-GAAP net loss and diluted net loss per

common share exclude the impact of the stock option expense recorded

in accordance with SFAS No. 123R. Amicus believes that excluding the

impact of expensing stock options better reflects the recurring

economic characteristics of its business.

(2) Other items -- Non-GAAP net loss and diluted net loss per common

share exclude other unusual or non-recurring items that are evaluated

on an individual basis. Amicus' evaluation of whether to exclude an

item for purposes of determining its non-GAAP financial measures

considers both the quantitative and qualitative aspects of the item,

including, among other things (i) its size and nature, (ii) whether

or not it relates to its ongoing business operations, and (iii)

whether or not Amicus expects it to occur as part of its normal

business on a regular basis. Items excluded for purposes of

determining non-GAAP net loss and
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