Navigation Links
Amgen's BiTE® Antibody Blinatumomab (AMG 103) Achieved High Rate of Complete Response in Adult Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia
Date:5/16/2012

s included molecular response rate, duration of response and overall survival. As of April 13, 2012, all 36 patients were evaluable for efficacy and safety.

About Blinatumomab
Blinatumomab (AMG 103) is a bispecific T cell engager (BiTE®) antibody designed to direct the body's cell-destroying T cells against target cells expressing CD19, a protein found on the surface of B-cell derived leukemias and lymphomas. The modified antibodies are designed to engage two different targets simultaneously, thereby juxtaposing T cells to cancer cells. Blinatumomab is the first of the BiTE antibodies and Amgen has received orphan drug designation from the U.S. Food and Drug Administration for the treatment of ALL, chronic lymphocytic leukemia (CLL), hairy cell leukemia, prolymphocytic leukemia and indolent B cell lymphoma and from the European Medicines Agency for the treatment of indolent B cell lymphoma, ALL, CLL and mantle cell leukemia (MCL).

About ALL
Acute lymphoblastic leukemia (ALL) is an aggressive cancer of the blood and bone marrow — the spongy tissue inside bones where blood cells are made. The disease progresses rapidly and affects immature blood cells, rather than mature ones.(1) Worldwide, ALL accounts for more than 12 percent of leukemia. Of the 42,000 people diagnosed worldwide, 31,000 will die from the disease.(2) Patients with ALL have abnormal white blood cells (lymphocytes) that crowd out healthy white blood cells, red blood cells and platelets, leading to infection, anemia (fatigue), easy bleeding and serious side effects.(3,4)

About Amgen
Amgen discovers, develops, manufactures and delivers innovative human therapeutics. A biotechnology pioneer since 1980, Amgen was one of the first companies to realize the new science's promise by bringing safe, effective medicines from lab to manufacturing plant to patient. Amgen therapeutics have changed the practice of medicine, helping millions o
'/>"/>

SOURCE Amgen
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Strategic Diagnostics Launches Initial Oncology-Targeted Antibody Reagent Catalog
2. MedImmune Announces Phase 2 Safety Data for Anti-RSV Antibody and National RSV Surveillance Results
3. Roche Announces Positive Results in Solid Tumors Using Human Monoclonal Antibody Against IGF-1R (R1507)
4. New Data Confirms That a Selective, Fully Human Anti-VEGF Antibody Being Developed by Peregrine is as Effective as Avastin(R) in Preclinical Cancer Models
5. Raven Announces Phase 1 Clinical Trial Results of RAV12 Therapeutic Antibody for Treatment of Adenocarcinomas
6. MedImmune Initiates First Clinical Trial of Monoclonal Antibody Targeting GM-CSFR in Patients with Rheumatoid Arthritis
7. Raven Announces Continued Enrollment of Phase 1/2a Clinical Trial of RAV12 Therapeutic Antibody for Treatment of Adenocarcinomas
8. Medarex Announces Allowance of Investigational New Drug Applications for Wholly Owned Fully Human Anti-CD19 Antibody, MDX-1342
9. Preclinical Studies Show Promise for Novel Antibody Therapy to Treat Acute Myeloid Leukemia (AML)
10. Celltrion and CSL Announce Collaboration to Develop and Manufacture Monoclonal Antibody
11. Micromet Announces the Publication of BiTE Antibody Review in Drugs of the Future
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2015)... 2015   Cypher Genomics, Inc., the ... showing that, compared to a panel of experts, ... equivalent interpretations of whether certain genetic abnormalities were ... a fraction of the time. Cypher,s Mantis software ... genetic analysis in non-invasive prenatal testing (NIPT) by ...
(Date:3/27/2015)... 2015 Zimmer Holdings, Inc. (NYSE and SIX: ZMH) ... trauma patients. Available in both small (6mm) ... External Fixation System from Zimmer is a modular system that ... The XtraFix System allows surgeons to eliminate steps, ... process, resulting in saved time, costs and overall team effort. ...
(Date:3/27/2015)... 2015 Report Details  ... drug companies  What does the future hold ... ? Visiongain,s brand new report shows you potential revenues ... Our 242-page report provides 185 tables, charts, ... industry and the future market prospects. Our new study ...
Breaking Medicine Technology:New Data at ACMG Shows Cypher's Software Can Automate Interpretation of Genetic Variants to Advance Non-invasive Prenatal Testing 2New Data at ACMG Shows Cypher's Software Can Automate Interpretation of Genetic Variants to Advance Non-invasive Prenatal Testing 3Zimmer Debuts New Modular External Fixation System 2Zimmer Debuts New Modular External Fixation System 3Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 2Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 3Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 4Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 5Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 6Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 7
(Date:3/29/2015)... 29, 2015 The Contract Research ... and research, manage data results and help develop ... reach regulation standards. Contract research organizations (CROs) mainly ... manufacturing sectors. Industry operators provide clients with a ... clinical research for Food and Drug Administration (FDA) ...
(Date:3/29/2015)... 2015 North American Seminars receives Texas ... Continuing Education Courses . , Utilizing Pilates ... - TPTA, approval # 56399TX      , The ... shoulder complex - 10.5 hours - Texas Board of ... and Treatment of the SI Joint - 10 hours ...
(Date:3/28/2015)... (PRWEB) March 28, 2015 "Necrorun" was ... which takes a look at the latest and coolest ... Joe Troohey, the host of NewsWatch and technology expert, ... this is an entertaining endless runner game with knights, ... game was released in 2009, according to Eurogamer. The ...
(Date:3/28/2015)... New York, NY (PRWEB) March 28, 2015 ... clinic that offers urgent care in Manhattan, recently commemorated ... urgent care facility in Manhattan. In addition to 24-hour ... to ER facilities. , At this time, Emergency ... treatments for abdominal pain, asthma, chest pain, eye injuries, ...
(Date:3/28/2015)... 28, 2015 One in three young ... research presented today at the American Orthopaedic Society for ... examined the long term success of surgery for patients ... survey data from 242 patients who underwent ACL reconstruction ... Roe, MBBS, FRACS, from North Sydney Orthopaedic and Sports ...
Breaking Medicine News(10 mins):Health News:Contract Research Organizations in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Contract Research Organizations in the US Industry Market Research Report from IBISWorld Has Been Updated 3Health News:Contract Research Organizations in the US Industry Market Research Report from IBISWorld Has Been Updated 4Health News:A Grim Endless Runner Game Was Featured on NewsWatch Television on January 30, 2015 2Health News:Emergency Medical Care Celebrates Three Years of 24/7 Walk-In Urgent Care Services 2Health News:Young Athletes at Greater Risk for Re-Injury after ACL Surgery 2
... are infected with noroviruses - commonly called stomach flu ... diarrhea. While most people recover in a few days, the ... especially among the elderly and infants - death. ... of Public Health have discovered that the virus mutates genetically, ...
... in the debut issue of SAGEs Foot & Ankle ... J. Stapleton, DPM, and Thomas S. Roukis, DPM, FACFAS, ... foot infections, recommending first controlling the infection by removing ... finally, restructuring the tissue to assure that the wound ...
... announced today its,agreement with Child Health Corporation ... vendor information, compliance and security,solution, available to ... leading health care providers like CHCA hospitals ... government-mandated regulations,including HIPAA, Stark Law, OIG and ...
... HR professional asks Senate to close FMLA loopholes, ... of,the world,s largest organization devoted to human resource ... that confusing loopholes in the,Family Medical and Leave ... ), "HR professionals have two primary concerns ...
... Alberta study, analyzing a sample of over 275,000 individuals, ... physical activity, one size does not fit all. , ... deciding how and if a person wants to be ... the University of Alberta. It is clear that different ...
... a,time to celebrate healthy relationships and this year the ... A Smile,(GBAS) program celebrates that and so much more. ... expertise pro bono to help,restore the smiles and lives ... GBAS cases have been completed for a total dollar ...
Cached Medicine News:Health News:Vaccine for stomach flu may be possible, UNC research shows 2Health News:Vendormate and CHCA Finalize Agreement to Offer Compliance and Security Solutions to Children's Hospitals 2Health News:Is a Common Cold a 'Serious Health Condition'? 2Health News:Study: When it comes to physical activity, one size does not fit all 2Health News:Caring Give Back A Smile Volunteer Dental Professionals Donate Over $5 Million in Services to Survivors of Domestic Violence 2
... COMBO 2 Assay is a second generation ... capture for in vitro qualitative detection and ... The assay uses a family of Gen-Probe's ... Amplification (TMA) and Dual Kinetic Assay (DKA). ...
... is a novel device for the ... gonorrhoeae and Neisseria meningitidis. This ... and is easily transportable as a ... incubate and examine the growth of ...
... NearVision™ CK is the only procedure designed for ... and +3.00 D or presbyopic patients who would ... D and 2.25 D to achieve a myopic ... in their non-dominant eye to temporarily improve near ...
... The CC-7000 is a mid range space ... take a non-contact picture of the corneal endothelium ... the corneal thickness in the central area. The ... 9" monitor, which is supplied with the system., ...
Medicine Products: